【单选题】
7) What time of history does pharmacodynamics date back to?___
A. the second half of the seventeenth century
B. the second half of the eighteenth century
C. the second half of the nineteenth century
D. the second half of the twentieth century
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【单选题】
8)What does the research on pharmacodynamics focus on?___
A. study of clinical effect of drugs
B. study of the process of drugs in the body
C. study of the effect and the mechanism of drugs on the body
D. study of the correlation of the actions and effects of drugs with their chemical structure
【单选题】
(9)Which of the following is true when drugs are selected?___
A. It has to be based in part on legal reasons.
B. It has to be based in part on ethical reasons.
C. It has to be based in part on the pharmacological evaluation in man
D. It has to be based in part on the pharmacological evaluation in animals
【单选题】
(10)Why are chemotherapeutic agents useful in therapy?___
A. They stimulate or depress biochemical or physiological function in man in a sufficiently reproducible manner to provide relief of symptoms or, ideally, to alter favorably the course of disease
B. They can produce desired effects with only tolerable undesired effects
C. They have only minimal effects on man but can destroy or eliminate parasites
D. The selectivity of their effects is one of their most important characteristics
【单选题】
1)H. Mario Geysen initially used parallel synthesis as a quick way to identify which small_____ of any given large protein bound to an antibody.___
A. division
B. pieces
C. part
D. fragment
【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
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【单选题】
配电设备检修，若无法保证安全距离或因工作特殊需要，可用与带电部分直接接触的( )隔板代替临时遮栏。
【单选题】
城区、( )或交通道口和通行道路上施工时，工作场所周围应装设遮栏(围栏)，并在相应部位装设警告标示牌。
A. 山区
B. 郊区
C. 有人区域
D. 人口密集区
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巡视工作应由( )的人员担任。
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B. 工作许可人
C. 值班负责人
D. 有配电工作经验
【单选题】
单独巡视人员应经( )批准并公布。
A. 公司领导
B. 工区领导
C. 工区
D. 安质部门
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电缆隧道、偏僻山区、夜间、事故或恶劣天气等巡视工作，应至少( )人一组进行。
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正常巡视应( )。
A. 穿绝缘鞋
B. 穿纯棉工作服
C. 穿绝缘靴
D. 戴手套
【单选题】
夜间巡线应携带足够的( )。
A. 干粮
B. 照明用具
C. 急救药品
D. 防身器材
【单选题】
灾害发生后，若需对配电线路、设备进行巡视，应得到( )批准。
A. 设备运维管理单位领导
B. 设备运维管理单位
C. 工作负责人
D. 值班调控人员
【单选题】
巡视中发现高压配电线路、设备接地或高压导线、电缆断落地面、悬挂空中时，室内人员应距离故障点( )m以外。
【单选题】
进入SF6配电装置室，应( )。
A. 先检测
B. 先通风
C. 使用防护用品
D. 先散热
【单选题】
配电站、开闭所、箱式变电站等的钥匙至少应有( )。
【单选题】
具备条件的设备可进行( )操作，即应用可编程计算机进行的自动化操作。
【单选题】
经设备运维管理单位考试合格、批准的检修人员，可进行配电线路、设备的监护操作，监护人应是同一单位的( )。
A. 检修人员
B. 设备运维人员
C. 工作负责人
D. 检修人员或设备运维人员
【单选题】
检修人员操作的设备和接、发令程序及安全要求应由( )批准，并报相关部门和调度控制中心备案
A. 公司
B. 工区
C. 设备运维管理单位
D. 安质部
【单选题】
若有可靠的确认和自动记录手段，可实行( )操作。
A. 远方单人
B. 远方
C. 单人
D. 程序
【单选题】
有与现场高压配电线路、设备和实际相符的系统模拟图或( )(包括各种电子接线图)。
A. 模拟图
B. 电气图
C. 地理图
D. 接线图
【单选题】
配电设备的防误操作闭锁装置不得随意退出运行，停用防误操作闭锁装置应经( )批准。
A. 工区领导
B. 工作负责人
C. 公司
D. 工区
【单选题】
短时间退出防误操作闭锁装置，由( )批准，并应按程序尽快投入。
A. 工区
B. 配电运维班班长
C. 调度控制中心
D. 防误专责人
【单选题】
设备检修时，回路中所有( )刀闸的操作手柄，应加挂机械锁。
A. 来电侧
B. 受电侧
C. 两侧
D. 负荷侧
【单选题】
发布指令的全过程(包括对方复诵指令)和听取指令的报告时，( )应录音并做好记录。
A. 低压指令
B. 高压指令
C. 所有指令
D. 单项指令
【单选题】
倒闸操作时，对指令有疑问时应向( )询问清楚无误后执行。
A. 工作负责人
B. 发令人
C. 工作许可人
D. 现场监护人
【单选题】
高压电气设备倒闸操作一般应由( )填用配电倒闸操作票(见附录J，以下简称操作票)。每份操作票只能用于一个操作任务。
A. 操作人员
B. 工作负责人
C. 工作监护人
D. 检修人员
【单选题】
已操作的操作票应注明( )字样。操作票至少应保存1年。
A. 已操作
B. 已执行
C. 合格
D. 已终结
【单选题】
操作票至少应保存( )。
A. 6个月
B. 1年
C. 2年
D. 1个月
【单选题】
倒闸操作中发生疑问时，( )。待发令人再行许可后，方可继续操作。
A. 不得更改操作票，应立即停止操作，并向发令人报告
B. 应立即停止操作，并向发令人报告
C. 不得更改操作票，应立即停止操作
D. 应立即向发令人报告
【单选题】
停电拉闸操作应按照( )的顺序依次进行，送电合闸操作应按与上述相反的顺序进行。禁止带负荷拉合隔离开关(刀闸)。
A. 断路器（开关）—负荷侧隔离开关（刀闸）—电源侧隔离开关（刀闸）
B. 负荷侧隔离开关（刀闸）——断路器（开关）——电源侧隔离开关（刀闸）
C. 断路器（开关）—电源侧隔离开关（刀闸）—负荷侧隔离开关（刀闸）
D. 负荷侧隔离开关（刀闸）——电源侧隔离开关（刀闸）——断路器（开关）
【单选题】
用间接方法判断操作后的设备位置时，至少应有两个( )指示发生对应变化，且所有这些确定的指示均已同时发生对应变化，方可确认该设备已操作到位。
A. 非同样构造或非同源的
B. 同样原理或同源的
C. 非同样原理或非同源的
D. 非同样原理或非同期的
【单选题】
若遇特殊情况需解锁操作，应经设备运维管理部门防误操作装置专责人或( )指定并经公布的人员到现场核实无误并签字。
A. 公司
B. 调控部门
C. 设备运维管理部门
D. 设备检修管理部门
【单选题】
断路器(开关)与隔离开关(刀闸)无机械或电气闭锁装置时，在拉开隔离开关(刀闸)前应( )。
A. 确认断路器（开关）操作电源已完全断开
B. 确认断路器（开关）已完全断开
C. 确认断路器（开关）机械指示正常
D. 确认无负荷电流
【单选题】
( )时，禁止就地倒闸操作和更换熔丝。
【单选题】
实行远方遥控操作，程序操作的设备、项目，需经( )批准。
A. 工作负责人
B. 工作签发人
C. 本单位
D. 监护人
【单选题】
( )断路器(开关)前，宜对现场发出提示信号，提醒现场人员远离操作设备。
A. 远方遥控操作
B. 远方程序操作
C. 就地操作
D. 拉开
【单选题】
远方遥控操作继电保护软压板，至少应有( )指示发生对应变化，且所有这些确定的指示均已同时发生对应变化，方可确认该压板已操作到位。
【单选题】
装设柱上开关(包括柱上断路器、柱上负荷开关)的配电线路停电，应( )。送电操作顺序与此相反。
A. 先断开柱上开关，后拉开隔离开关（刀闸）
B. 先拉开隔离开关（刀闸），后断开柱上开关
C. 先停主线开关，后停支线柱上开关
D. 先停支线柱上开关，后停主线开关
【单选题】
配电变压器停电，应( )。送电操作顺序与此相反
A. 先拉开高压侧熔断器，后拉开低压侧开关（刀闸）
B. 先拉开低压侧开关（刀闸），后拉开高压侧熔断器
C. 先拉开低压侧分路开关，后拉开低压侧总开关
D. 先拉开低压侧总开关，后拉开低压侧分路开关
【单选题】
摘挂跌落式熔断器的熔管，应使用( )，并派人监护。
A. 绝缘棒
B. 验电器
C. 操作杆
D. 专用工具
【单选题】
砍剪靠近带电线路的树木，( )应在工作开始前，向全体作业人员说明电力线路有电。
A. 工作负责人
B. 工作许可人
C. 工作票签发人
D. 专业室领导
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砍剪靠近带电线路的树木，工作负责人应在工作开始前，向全体作业人员说明电力线路有电；人员、树木、绳索应与导线保持10kV( )m的安全距离。
A. 0.7
B. 1.0
C. 1.5
D. 3.0
【单选题】
为防止树木(树枝)倒落在线路上，应使用绝缘绳索将其拉向与线路( )的方向，绳索应有足够的长度和强度，以免拉绳的人员被倒落的树木砸伤。
A. 相反
B. 60°
C. 90°
D. 相同
【单选题】
上树时，应使用安全带，安全带不得系在待砍剪树枝的( )附近或以上。不得攀抓脆弱和枯死的树枝；不得攀登已经锯过或砍过的未断树木。
