【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
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【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
【判断题】
5)Bioavailability of a drug indicates whether a therapeutically effective concentration is achieved at the site(s)of action of that drug.
【判断题】
(6)Prodrugs are not therapeutically effective unless they are changed into therapeutically active forms before or after reaching the systemic circulation
【单选题】
（1）地球表层覆盖着很多圈层，其中最厚的圈层是 ___
A. 岩石圈
B. 水圈
C. 大气圈
D. 生物圈
【单选题】
（2）目前受人类影响最强烈的地球圈层部位主要在大气圈底层、岩石圈上层以及 ___
A. 生物圈表层
B. 生物圈中层
C. 水圈底层
D. 水圈全部
【单选题】
（3）生物圈的范围为___
A. 大气圈、水圈和岩石圈的全部
B. 大气圈和水圈的全部、岩石圈的上部
C. 大气圈的底部、水圈和岩石圈的全部
D. 大气圈的底部、水圈的全部和岩石圈的上部
【单选题】
（4）地球上最大的生态系统是 ___
A. 森林生态系统
B. 生物圈
C. 海洋生态系统
D. 城市生态系统
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上下脚手架应走斜道或梯子，禁止作业人员沿( )等攀爬。 ___
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高处作业时，梯子的支柱应能承受攀登时( )的总重量。___
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C. 检修（施工）复杂容易发生事故的工作；
D. 涂写杆号
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职业精神是从事某职业该有的（ ）。 ___
【判断题】
企业精神是企业员工的精神支柱和活力源泉。
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到2035年，国家电网公司将基本建成具有卓越竞争力的世界一流能源互联网企业。
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事故紧急抢修工作，指电气设备发生故障被迫紧急停止运行，需按计划恢复的抢修和排除故障的工作。
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新参加电气工作的人员、实习人员和临时参加劳动的人员（管理人员、非全日制用工等），应经过安全知识教育后，方可到现场单独工作。
【判断题】
作业人员对本规程应每年考试一次。因故间断电气工作连续3个月以上者，应重新学习本规程，并经考试合格后， 方能恢复工作。
【判断题】
作业人员基本条件之一是：经医院鉴定，无妨碍工作的病症（体格检查每两年至少一次） 。
【判断题】
待用间隔的隔离开关(刀闸)操作手柄、网门可不加锁。
【判断题】
倒闸操作的基本条件之一：有与现场一次设备和实际运行方式相符的一次系统模拟图(包括各种电子接线图)。
【判断题】
一个工作负责人可以同时执行多张工作票，工作票上所列的工作地点，以一个电气连接部分为限。
【判断题】
工作票有破损不能继续使用时，应补填新的工作票。补填的工作票不需再次履行签发许可手续。
【判断题】
只有在同一停电系统的所有工作票都已终结，并得到值班调控人员或运维负责人的许可指令后，方可合闸送电。
【判断题】
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【判断题】
禁止作业人员擅自移动或拆除遮栏（围栏）、标示牌。
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高架绝缘斗臂车在工作过程中，高架绝缘斗臂车的发动机可以熄火。
【判断题】
带电作业工具放置在防潮的帆布或绝缘垫上，防止绝缘工具在使用中脏污和受潮。
【判断题】
禁止在转动着的发电机、同期调相机的回路上工作，或用手触摸高压绕组。
【判断题】
禁止在转动中的电动机的接地线上进行工作。
【判断题】
尽量避免一人进入SF6配电装置室进行巡视或从事检修工作。
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电力电缆作业，掘路施工区域应用标准路栏等严格分隔，并有明显标记，夜间施工人员应佩戴反光标志，施工地点应加挂警示灯。
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开启电缆井井盖、电缆沟盖板及电缆隧道人孔盖时应使用专用工具，同时注意所立位置。
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禁止把氧气瓶及乙炔气瓶放在一起运送，也不准与易燃物品或装有可燃气体的容器一起运送。
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厂房内的桥式起重机作业完毕后应停放在指定地点。
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