【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
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相关试题
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
【判断题】
5)Bioavailability of a drug indicates whether a therapeutically effective concentration is achieved at the site(s)of action of that drug.
【判断题】
(6)Prodrugs are not therapeutically effective unless they are changed into therapeutically active forms before or after reaching the systemic circulation
【单选题】
（1）地球表层覆盖着很多圈层，其中最厚的圈层是 ___
A. 岩石圈
B. 水圈
C. 大气圈
D. 生物圈
【单选题】
（2）目前受人类影响最强烈的地球圈层部位主要在大气圈底层、岩石圈上层以及 ___
A. 生物圈表层
B. 生物圈中层
C. 水圈底层
D. 水圈全部
【单选题】
（3）生物圈的范围为___
A. 大气圈、水圈和岩石圈的全部
B. 大气圈和水圈的全部、岩石圈的上部
C. 大气圈的底部、水圈和岩石圈的全部
D. 大气圈的底部、水圈的全部和岩石圈的上部
【单选题】
（4）地球上最大的生态系统是 ___
A. 森林生态系统
B. 生物圈
C. 海洋生态系统
D. 城市生态系统
推荐试题
【单选题】
线路设备状态评定时，___分为合格。
A. 85-100
B. 70-85
C. 60-85
D. 60-90
【单选题】
关于线路轨道、道岔保养质量评定,___时间由工务中心评定一次。
A. 半年
B. 三个月
C. 一年
D. 一个月
【单选题】
工务中心组织对正线轨道和道岔评定一次，采取___检查办法进行。
A. 定点检查
B. 随机抽样
C. 固定一样
D. 不检查
【单选题】
___的检查，是轨道动态质量检查的主要手段。
A. 轨道检测车
B. 人工添乘
C. 添乘仪
D. 钢轨打磨车
【单选题】
管理分工分为设___三级管理职责。
A. 中心、班组、部门
B. 部门、班组、中心
C. 部门、中心、班组
D. 中心、部门、班组
【单选题】
按照___的原则，运营分公司授权工务中心直接对委外单位（人员）进行管理。
A. 一般
B. 部门规定
C. 中心规定
D. 谁使用、谁管理、谁考核
【单选题】
委外单位依据___原则合理编制月度（周）计划，报中心批准
A. 先严重、后一般
B. 先一般、后严重
C. 中心制定的年度计划
D. 现场设备
【单选题】
中心根据___,编制设施设备年度检修计划及巡视计划。
A. 设备维护周期
B. 设备实际状态及维护周期
C. 设备实际状态
D. 随意规定
【单选题】
对于一些结构特殊故障、损坏，委外单位应提供___供中心审批后才可开展有关维护工作。
A. 详细的施工方案
B. 什么都不用
C. 随意的施工方案
D. 口头的施工方案
【单选题】
___是地铁运营工作的生命线。
A. 管理
B. 生产
C. 后勤保障
D. 安全
【单选题】
工务及委外维保单位人员必须坚决坚持___的方针，把安全工作放在首位
A. 生产是第一要素
B. 安全第一、预防为主
C. 安全第一
D. 预防第一
【单选题】
维修人员必须严格执行___等基本安全生产制度。
A. 安全第一、预防为主
B. 三不离、四不放过
C. 三不动、三不离、四不放过
D. 无
【单选题】
各作业单位在施工结束前务必做到___。
A. 人员出清
B. 工具出清
C. 物料出清
D. 工完、料尽、场地清
【单选题】
加强维修管理，做到___。
A. 保安全、保质量、保费用
B. 工具器安全
C. 保安全、保质量
D. 设备安全
【单选题】
道岔平面：半割线型曲线尖轨（割距4mm），割线型直线辙叉（割距12mm），导曲线半径___。
A. 250m
B. 100m
C. 150m
D. 200m
【单选题】
___是引导车辆由一条线路转往另一条线路的过渡设备。
【单选题】
道岔设备修理分为___三大层次。
A. 经常保养、维修和大修
B. 临时抢修、维修和大修
C. 临时抢修、巡检和维修
D. 巡检、维修和大修
【单选题】
停车场50kg/m钢轨___单开道岔。
A. 9号
B. 7号
C. 11号
D. 10号
【单选题】
正线整体道床___钢轨9号单开道岔及交叉渡线。
A. 60kg/m
B. 50kg/m
C. 75kg/m
D. 65kg/m
【单选题】
停车场___钢轨7号单开道岔。
A. 60kg/m
B. 50kg/m
C. 75kg/m
D. 65kg/m
【单选题】
正线整体道床60kg/m钢轨___单开道岔及交叉渡线。
【单选题】
道岔电务转换设备采取___。
A. 直接锁闭
B. 外锁闭
C. 联动内锁闭
D. 联动外锁闭
【单选题】
道岔电务转换设备联动内锁闭，一点牵引，牵引点动程为___。
A. 148mm
B. 160mm
C. 150mm
D. 152mm
【单选题】
道岔转辙器采用___曲线型尖轨。
A. 45AT
B. 60AT
C. 50AT
D. 55AT
【单选题】
道岔转辙器采用50AT曲线型尖轨，尖轨长___。
A. 5110mm
B. 5120mm
C. 5100mm
D. 5150mm
【单选题】
2号线正线护轨为分开式，采用___钢轨制造。
A. 43kg/m
B. 50kg/m
C. 60kg/m
D. 75kg/m
【单选题】
护轨顶面要高出基本轨___。
A. 15mm
B. 10mm
C. 12mm
D. 14mm
【单选题】
轨距垫分中间轨距垫和接头轨距垫，各设___，共4个号码
A. 4、8、10、14
B. 4、6、12、14
C. 4、6、8、10
D. 6、8、10、12
【单选题】
钢轨接头两侧采用___。
A. 接头轨距垫
B. 普通轨距块
C. 备用轨距块
D. 中间轨距块
【单选题】
正线9号道岔直股轨距为___。
A. 1440mm
B. 1435mm
C. 1445mm
D. 1430mm
【单选题】
正线9号道岔曲股轨距加宽___。
A. 10mm
B. 8mm
C. 5mm
D. 0mm
【单选题】
停车场7号道岔曲股轨距为___。
A. 10mm
B. 5mm
C. 15mm
D. 0mm
【单选题】
正线采用相离圆曲线线型，___弹性可弯尖轨。
A. 75AT
B. 55AT
C. 50AT
D. 60AT
【单选题】
尖轨非工作边、工作边斜度均为___。
A. 0.043055556
B. 0.044444444
C. 0.04375
D. 0.042361111
【单选题】
2号线正线尖轨设两个牵引点，第一牵引点动程为___，第二牵引点动程为(A)。
A. 160mm 80mm
B. 160mm 120mm
C. 120mm 80mm
D. 120mm 60mm
【单选题】
单开辙叉、交叉渡线锐角辙叉、交叉渡线钝角辙叉采用___整铸辙叉。
A. 普通碳素结构钢
B. 低合金结构钢
C. 高锰钢
D. 调质结构钢
【单选题】
2号线正线道岔护轨采用分开式，采用___钢轨制造。
A. 60kg/m
B. 43kg/m
C. 75kg/m
D. 50kg/m
【单选题】
4号线正线尖轨设两个牵引点，第一牵引点动程为___，第二牵引点动程为(B)。
A. 160mm 80mm
B. 160mm 84mm
C. 120mm 84mm
D. 120mm 80mm
【单选题】
4号线正线尖轨理论总扳动力不大于___。
A. 4KN
B. 3KN
C. 5KN
D. 2KN
【单选题】
4号线正线护轨采用分开式可调护轨，采用___钢轨制造。
A. 60kg/m
B. 50kg/m
C. UIC33槽形
D. 43kg/m
