【单选题】
8)What does the research on pharmacodynamics focus on?___
A. study of clinical effect of drugs
B. study of the process of drugs in the body
C. study of the effect and the mechanism of drugs on the body
D. study of the correlation of the actions and effects of drugs with their chemical structure
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相关试题
【单选题】
(9)Which of the following is true when drugs are selected?___
A. It has to be based in part on legal reasons.
B. It has to be based in part on ethical reasons.
C. It has to be based in part on the pharmacological evaluation in man
D. It has to be based in part on the pharmacological evaluation in animals
【单选题】
(10)Why are chemotherapeutic agents useful in therapy?___
A. They stimulate or depress biochemical or physiological function in man in a sufficiently reproducible manner to provide relief of symptoms or, ideally, to alter favorably the course of disease
B. They can produce desired effects with only tolerable undesired effects
C. They have only minimal effects on man but can destroy or eliminate parasites
D. The selectivity of their effects is one of their most important characteristics
【单选题】
1)H. Mario Geysen initially used parallel synthesis as a quick way to identify which small_____ of any given large protein bound to an antibody.___
A. division
B. pieces
C. part
D. fragment
【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
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【单选题】
本装置的制冷剂是___。
A. F12
B. F22
C. 丙烯
D. 乙二醇
【单选题】
经过PA601冷冻机后其冷冻水给水RWS温度是___。
A. -2℃
B. 2℃
C. 10℃
D. 20℃
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D301高压引起I301联锁的压力设定值为___。
A. 2.2MPaG
B. 2.1MPaG
C. 2.0MPaG
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自E301的尾气的取样点为___。
A. AC11
B. AC13
C. AC14
D. AC12
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D301低温TALL30003引起I301联锁的设定值为___。
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SR301/D501压差PDALL30103，引起I304联锁的设定值为___。
A. 0.005MPaG
B. 0.008MPaG
C. 0.01MPaG
【单选题】
聚丙烯装置低压排放罐的压力一般在___Mpa。
A. 0.03-0.04
B. 0.04-0.05
C. 0.05-0.08
D. 火炬背压
【单选题】
HV30001切向排放时一般指向___。
【单选题】
原料丙烯中的水含量工艺指标设计要求小于___ppm。
【单选题】
C701主要作用是去除原料中的___。
A. CO
B. H2O
C. COS
D. O2
【单选题】
C703再生使用的介质是___。
A. 热氮气
B. 丙烯气
C. 氢气
D. 空气
【单选题】
C701系统的FV70002排往界区___系统。
【单选题】
C702A/B中装填的催化剂的名称___。
A. COS水解催化剂、氧化锌脱硫剂
B. 3A分子筛
C. 1"INTALOX填料
【单选题】
700#初始开车置换用的丙烯___。
A. 界区丙烯通过蒸汽夹套
B. E302的气相丙烯
C. D302中的液相丙烯
【单选题】
C701压力升高，PC70003MV应做___调整。
【单选题】
聚丙烯熔点为___。
A. 100～120℃
B. 120～140℃
C. 164～170℃
D. 180℃
【单选题】
MI的单位是___。
A. g/min
B. g/10min
C. g/h
【单选题】
R201聚合反应器的高度是___。
A. 50m
B. 24m
C. 30m
D. 45m
【单选题】
引丙烯时，管线或设备应最好升压至___。
A. 6kg/cm2
B. 5kg/cm2
C. 7kg/cm2左右
D. 2kg/cm2
【单选题】
对聚丙烯树脂而言，熔融指数升高则___。
A. 相对分子质量增加，流动性提高
B. 相对分子质量减小，流动性提高
C. 相对分子质量减小，流动性下降
D. 相对分子质量增加，流动性不变
【单选题】
无规共聚物与均聚物相比冲击强度和___能有所提高。
A. 透明性
B. 弹性
C. 拉伸强度
D. 热变形
【单选题】
过氧化物的加料位置在___。
A. 助剂加料秤
B. 挤压机料斗顶部
C. 挤压机料斗底部
D. 无所谓
【单选题】
若熔融指数升高，则切粒水温应该___。
【单选题】
通常MFR越高，造粒单元___。
A. 切粒机转速越高
B. 切粒机转速越低
C. 网压越高
【单选题】
气蚀的主要原因是___。
A. 泵的入口压力低于该温度下的液体饱和蒸汽压.
B. 吸入液体压力低
C. 泵出口压力高
D. 泵体没有冲洗
【单选题】
聚丙烯BOPP产品能做___制品。
A. 食品包装薄膜.
B. 农膜
C. 无纺布
D. 合成纸
【单选题】
在装置生产中，环管反应器压力控制在___。
A. 3.0MPa±0.1MPa
B. 3.4MPa±0.1MPa
C. 4.2MPa±0.1MPa
D. 4.5MPa±0.1MPa
【单选题】
环管夹套水泵在启动前要确认___。
A. 环管充满丙烯
B. 环管夹套充满脱盐水，夹套内没有气体
C. 轴流泵启动
D. 夹套水加热器投用
【单选题】
丙烯汽化器引丙烯时要___。
A. 先引丙烯，后投蒸汽
B. 先投蒸汽，后引丙烯
C. 丙烯、蒸汽一起投用
D. 无需投用
【单选题】
在PP装置中预聚合反应器夹套水流向和循环物流向是___。
A. 并流
B. 逆流
C. 交叉错流
D. 不要求夹套水流向
【单选题】
安全阀投用时，前后切断阀应打开，副线阀应___。
A. 打开
B. 关闭
C. 开一半
D. 开关无所谓
【单选题】
在聚丙烯装置中一氧化碳是用来___。
A. 提高反应活性
B. 提高主催化剂收率
C. 终止反应
D. 降低三乙基铝用量
【单选题】
在相同密度下，生产无规共聚产品时轴流泵的功率比生产均聚产品时的功率___。
A. 相同
B. 增加
C. 降低
D. 先增加后降低
【单选题】
R200的体积和停留时间分别为___。
A. 0.5M3，10-12分钟
B. 1M3，10-12分钟
C. 2M3，10-12分钟
【单选题】
在聚丙烯装置的流程图中符号SL表示___。
A. 浆液
B. 低压蒸汽
C. 凝液
D. 高压蒸汽
【单选题】
造粒助剂下料波动的处理办法有___。
A. 更换新的助剂
B. 清理下料螺杆
C. 通知相关人员处理仪表问题
D. 以上说法都对
【单选题】
添加剂下料不好的处理办法有___。
A. 更换新的添加剂.
B. 清理下料螺杆
C. 通知相关人员处理仪表问题
D. 以上说法都对
