【单选题】
(9)Which of the following is true when drugs are selected?___
A. It has to be based in part on legal reasons.
B. It has to be based in part on ethical reasons.
C. It has to be based in part on the pharmacological evaluation in man
D. It has to be based in part on the pharmacological evaluation in animals
查看试卷,进入试卷练习
微信扫一扫,开始刷题
相关试题
【单选题】
(10)Why are chemotherapeutic agents useful in therapy?___
A. They stimulate or depress biochemical or physiological function in man in a sufficiently reproducible manner to provide relief of symptoms or, ideally, to alter favorably the course of disease
B. They can produce desired effects with only tolerable undesired effects
C. They have only minimal effects on man but can destroy or eliminate parasites
D. The selectivity of their effects is one of their most important characteristics
【单选题】
1)H. Mario Geysen initially used parallel synthesis as a quick way to identify which small_____ of any given large protein bound to an antibody.___
A. division
B. pieces
C. part
D. fragment
【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
【单选题】
3)The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
(2)Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
(7)Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
(3) As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site(s) of action.
推荐试题
【判断题】
[47][判断]电缆试验结束,应在被试电缆上加装临时接地线,待电缆尾线接通后方可拆除
【判断题】
[48][判断]在居民区和交通道路附近立、撤杆时,应具备相应的交通组织方案,并设警戒范围或警示标志,必要时派专人看守
【判断题】
[49][判断]手提式和推车式干粉、二氧化碳灭火器出厂日期满5年,以后每隔2年,必须进行水压试验等维修
【判断题】
[50][判断]在登高、高处转移作业位置及高处作业时不应失去安全保护
【判断题】
[51][判断]在杆塔或横担接地良好的条件下,个人保安线接地端可接在杆塔或横担上
【判断题】
[52][判断]架空绝缘导线线路与裸导线线路停电作业的安全要求不相同
【判断题】
[53][判断]基层单位应按照“属地化管理”原则对设备、设施和作业活动开展安全风险识别
【判断题】
[54][判断]装、拆接地线导体端应使用绝缘棒或专用的绝缘绳,人体可以碰触接地线
【判断题】
[55][判断]绝缘操作杆、验电器和测量杆允许使用电压应比设备电压等级稍低
【判断题】
[56][判断]交通信号灯由红灯、绿灯、黄灯组成,红灯表示禁止通行,绿灯表示准许通行,黄灯表示警示
【判断题】
[57][判断]在禁火区、易燃易爆场所等规定区域内进行用火作业,均应按所在作业区主管单位的规定办理用火许可手续
【判断题】
[58][判断]在隐患排查治理工作中安全管理制度不完善属于安全管理上的缺陷
【判断题】
[59][判断]手提式灭火器适用于错类火灾中的水溶性可燃、易燃火灾
【判断题】
[60][判断]有许可要求的作业在作业前必须进行JS对分析
【判断题】
[61][判断]绑线应在下面绕成小盘再带上杆塔使用,也可以在在杆塔上卷绕或放开绑线
【判断题】
[62][判断]许可工作可采取的命令方式有电话下达、当面下达、派人送达和约时
【判断题】
[63][判断]安全风险按重大风险、较大风险、一般风险和低风险分级管理,分别用红、橙、黄、蓝颜色标示
【判断题】
[64][判断]装设接地线时,应先装地端,后装导线端,拆除时顺序相同
【判断题】
[65][判断]个体劳动防护用品破损或变形、影响防护性能或达到报废期限时,应报废,并予以更换或补发
【判断题】
[66][判断]环网柜、电缆分支箱等箱式设备宜设置验电和接地装置
【判断题】
[67][判断]事故隐患分为一般事故隐患和重大事故隐患
【判断题】
[68][判断]安全工器具使用前不用进行外观检查
【判断题】
[69][判断]遇有电气设备着火时,应立即将有关设备的电源切断,然后进行灭火
【判断题】
[70][判断]电力电缆工作前,应核对电缆标志牌的名称与工作票所填写的相符,安全措施正确完备后,方可开始工作
【判断题】
[71][判断]重大事故隐患,是指危害和整改难度较大,应当全部或者局部停产停工,并经过一定时间整改治理方能排除的隐患
【判断题】
[72][判断]无接地引下线或接地不良的杆塔装设接地线时,可采用临时接地体
【判断题】
[73][判断]在距坠落高度基准面1.5m或1.5m以上有可能坠落的高处进行的作业称为高处作业
【判断题】
[74][判断]工作许可人的安全职责包括审查工作的必要性;确认工作票所列安全措施正确完备,符合现场实际条件;确认线路停、送电和许可工作的命令正确;确认许可的接地等安全措施正确完备
【判断题】
[75][判断]一个工作负责人可以同时执行两张工作票
【判断题】
[76][判断]新立杆塔在杆基未完全牢固或做好拉线前,可以攀登
【判断题】
[77][判断]链条葫芦使用前应检查吊钩、链条、传动装置及刹车装置状态良好
【判断题】
[78][判断]高处作业应使用工具袋,下传递物件应用绳索拴牢传递,不应上下抛掷
【判断题】
[79][判断]经安全知识教育之后的新入厂人员可以单独工作
【判断题】
[80][判断]基层岗位应按作业活动步骤开展安全风险识别
【判断题】
[81][判断]在运行的配电设备上工作应填写第一种工作票
【判断题】
[82][判断]需要线路全部停电或部分停电的工作应填写第一种工作票
【判断题】
[83][判断]电缆施工完成后应将穿越过的孔洞进行封堵,进入电缆工井、控制柜、开关柜等处的电缆孔洞,应用固体材料封闭
【判断题】
[84][判断]发生人身触电时,应立即断开有关设备的电源
【判断题】
[85][判断]利用高空作业车、带电作业车、高处作业平台等进行高处作业,作业平台应处于稳定状态;车辆移动时,作业平台上可以载人
【判断题】
[86][判断]对存在职业病危害因素超标等隐患的作业场所,立即采取有效措施和治理措施,未采取有效防护措施的,不得安排从业人员在超标环境中作业