【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
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【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
【判断题】
5)Bioavailability of a drug indicates whether a therapeutically effective concentration is achieved at the site(s)of action of that drug.
【判断题】
(6)Prodrugs are not therapeutically effective unless they are changed into therapeutically active forms before or after reaching the systemic circulation
【单选题】
（1）地球表层覆盖着很多圈层，其中最厚的圈层是 ___
A. 岩石圈
B. 水圈
C. 大气圈
D. 生物圈
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【单选题】
作业人员___前，应当接受安全生产教育培训。未经教育培训或者教育培训考核不合格的人员，不得上岗作业。
A. 进入新的岗位
B. 进入新的施工现场
C. 进入新的岗位或者每周一上班
D. 进入新的岗位或者新的施工现场
【单选题】
下列哪个选项不是作业人员作业前应检查的内容___。
A. 工具、设备是否存在不安全因素
B. 现场环境是否存在不安全因素
C. 是否正确穿戴个人防护用品
D. 施工方案是否完善
【单选题】
作业中出现危险征兆时，作业人员应___。
A. 立即向作业队长汇报，原地待命
B. 立即停止作业、从安全通道撤离至安全区域，及时向主管领导汇报
C. 继续作业，等待技术人员判断危险程度
D. 继续作业，等待主管领导下达命令
【单选题】
下列哪个选项不包括在施工过程三不伤害之中___。
A. 不伤害自己
B. 不伤害他人
C. 不被机械伤害
D. 不被他人伤害
【单选题】
制定安全生产责任制的目的是___。
A. 增强员工安全意识
B. 增强领导安全意识
C. 明确岗位安全责任
D. 明确领导安全责任
【单选题】
作业人员在管道和污水井内作业应采取哪些措施___。
A. 不需采取措施，直接下井作业
B. 作业前应对有害气体进行检测和排放
C. 作业前应派专人下井检查作业区域情况
D. 作业前应对有害气体进行检测和排放，向管道和井道内输入新鲜空气，并保持通风良好
【单选题】
作业人员在机械挖土清理基坑时，___进入铲斗回转半径范围。
【单选题】
以下哪个选项不包括在建筑施工中常说的“四口”之中___。
A. 通道口
B. 大门口
C. 楼梯口
D. 预留洞口
【单选题】
患有下列哪种疾病的人员仍可以从事架子工作 ___。
A. 高血压
B. 心脏病
C. 口腔溃疡
D. 癫痫病
【单选题】
脚手架拆除时下方应设___，派专人旁站，自上而下拆除，严禁向下抛掷。
A. 加工区
B. 料场
C. 防护棚
D. 警戒区
【单选题】
遇有___级以上大风时应停止室外高处作业。
【单选题】
搭、拆脚手架时作业人员必须戴___，系安全带，穿防滑鞋。
A. 护目镜
B. 安全帽
C. 耳塞
D. 耳机
【单选题】
电动吊篮作业人员的安全带必须挂在___。
A. 吊篮栏杆上
B. 吊篮升降钢索上
C. 保险绳上
D. 不需要使用安全带
【单选题】
在吊运和安装大模板或预制构件时，吊钩下方严禁___，吊运前要认真检查吊索具和被吊点是否牢靠，听从信号工指挥。
【单选题】
下列哪个选项不是电工带电作业时必须遵守的安全要求___。
A. 穿绝缘鞋
B. 戴绝缘手套
C. 必须有人监护，严禁酒后操作
D. 挂安全带
【单选题】
下列哪个选项不是常用的安全电压___。
A. 12V
B. 110V
C. 24V
D. 36V
【单选题】
在特别潮湿和金属容器内作业使用的照明电压不得超过___V。
【单选题】
人工挖扩孔时，孔下照明必须使用___V以下安全电压照明。
【单选题】
高压架空线路断线，线头落在身旁的地面上，应一脚抬起或两脚在一起蹦出___m以外，并设法切断电源或采取措施防止他人靠近。
【单选题】
进行拆、搭金属构架作业时，人及物体与一般带电设备应保持的安全距离是___m。
A. 1.5
B. 2.O
C. 2.5
D. 3.0
【单选题】
电器灭火时不能采用哪种灭火器___。
A. 二氧化碳灭火器
B. 泡沫灭火器
C. 四氯化碳灭火器
D. 干粉灭火器
【单选题】
遇有___时不能在塔吊导轨旁边和物料提升机的周围进行作业。
【单选题】
电焊机二次线应使用专用焊把线，___到位，焊把线不得有裸露接头，严禁借用金属管道、脚手架等金属物代替导线使用。
A. 单线
B. 双线
C. 保护零线
D. 工作零线
【单选题】
氧气瓶、乙炔瓶使用及存放时的间距应不小于___m。
【单选题】
手持电动工具应绝缘良好，必须装有合格的___保护装置，禁止拆改电源线和插头，并使用专用流动开关箱。
【单选题】
打夯机的电源控制开关必须使用___开关。
【单选题】
圆盘锯的___部位应安装保护挡板或防护罩。
【单选题】
操作机械时工人应穿___。
A. 宽松工作服
B. 紧身工作服，袖口不用上松紧带
C. 宽松工作服，袖口是松紧式
D. 紧身工作服，袖口是松紧式
【单选题】
钢筋加工机械和木工机械___由未经专业培训的人员操作。
【单选题】
使用无齿锯时应注意：锯片无裂痕和变形，禁止___，锯片的切线方向严禁站人，无齿锯应有防护罩，不得在锯片侧面打磨物料。
【单选题】
人工开挖土方，两人横向间距不得小于___m。
【单选题】
人工开挖土方，两人纵向间距不得小于___m。
【单选题】
沟槽施工中发现沟、槽边坡有裂纹或部分下沉时，___。
A. 立即将人员撤到安全位置，并及时报告有关部门，严禁冒险作业。
B. 首先报告有关部门，工人原地待命
C. 立即将人员撤到安全位置，自行处理隐患。
D. 让工人自行处理隐患。
【单选题】
槽、坑、沟边1m外的堆土高度不得超过___m。
【单选题】
安全带的正确系挂方法是___。
A. 随意系挂
B. 低挂高用
C. 高挂低用
D. 根据现场情况系挂
【单选题】
凡在坠落基准面___m以上(含)有可能坠落的高处进行的作业为高处作业。
【单选题】
高处作业时手持工具和零星物料应放在___。
A. 上衣口袋
B. 裤兜
C. 工具袋
D. 脚手板上
【单选题】
上下交叉施工作业时应采取___措施。
A. 防护隔离
B. 防护
C. 隔离
D. 砂石
【单选题】
临边作业时操作人员的___应位于室内，不得在窗台上站立，必要时应系好安全带。
