【单选题】
(10)Why are chemotherapeutic agents useful in therapy?___
A. They stimulate or depress biochemical or physiological function in man in a sufficiently reproducible manner to provide relief of symptoms or, ideally, to alter favorably the course of disease
B. They can produce desired effects with only tolerable undesired effects
C. They have only minimal effects on man but can destroy or eliminate parasites
D. The selectivity of their effects is one of their most important characteristics
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相关试题
【单选题】
1)H. Mario Geysen initially used parallel synthesis as a quick way to identify which small_____ of any given large protein bound to an antibody.___
A. division
B. pieces
C. part
D. fragment
【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
推荐试题
【单选题】
路基设置中土质边坡坡度为（ ）。 ___
A. 1：1-1：1.5
B. 1：1-1：1.5
C. 1：1.5-1：2
D. 1：2-1：2.5
【单选题】
平台宽度根据路堑深度和地层性质等因素确定，一般为（ ）。 ___
A. 0.5~1.0m
B. 1~1.5m
C. 1.5~2m
D. 2~2.5m
【单选题】
平台宽度根据路堑深度和地层性质等因素确定并向侧沟方向做成（ ），便于横向排水。 ___
A. 1%~2%
B. 2%~4%
C. 4%~6%
D. 6%~8%
【单选题】
设置地面排水设施时，横向排水坡一般不小于（ ）(路拱的高度就是按此横坡确定的)，以便迅速排水。 ___
【单选题】
设置地面排水设施时，纵坡不小于（ ），不大于（ ）。 ___
A. 2‰ 8‰
B. 3‰ 9‰
C. 4‰ 10‰
D. 5‰ 12‰
【单选题】
普通排水沟，底宽一般为（ ），深度为（ ）。 ___
A. 0.2m 0.4m
B. 0.4m 0.6m
C. 0.6m 0.8m
D. 0.8m 1m
【单选题】
小桥:长度在（ ）及以下的桥梁称为小桥。 ___
A. 5m
B. 10m
C. 20m
D. 25m
【单选题】
中桥:长度在（ ）的桥梁称为中桥。 ___
A. 40m-120m
B. 40m-10Om
C. 20m-120m
D. 20m-10Om
【单选题】
大桥:长度在（ ）的桥梁称为大桥。 ___
A. 100m-300m
B. 100m-400m
C. 100m-500m
D. 100m-600m
【单选题】
特大桥:长度在（ ）以上的桥梁称为特大桥。 ___
A. 400m
B. 500m
C. 600m
D. 700m
【单选题】
圆形隧道内径为（ ），由6块钢筋混凝土管片装配成环。 ___
A. 4.5m
B. 5.0m
C. 5.5m
D. 6.0m
【单选题】
圆形隧道内径为5.5m，由（ ）块钢筋混凝土管片装配成环。 ___
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【单选题】
矩形隧道单线净断面为（ ）(宽)×（ ）(高)，双线净宽为9.5~14.6m，为现浇钢筋混凝土结构。 ___
A. 4.3 m 5m
B. 4.2 m 5.5m
C. 4.1 m 6m
D. 4.0 m 6.5m
【单选题】
矩形隧道单线净断面为4.3 m(宽)×5m(高)，双线净宽为（ ），为现浇钢筋混凝土结构。 ___
A. 9.2~14.3m
B. 9.3~14.4m
C. 9.4~14.5m
D. 9.5~14.6m
【单选题】
根据大量实测资料分析结果表明自路基下0.5m深度范围内受动力影响最大，路基面下（ ）处路基动应力约为路基面应力的三分之一。 ___
A. 0.5m
B. 1.Om
C. 1.5m
D. 2.Om
【单选题】
破底清筛后，枕下清碎厚度不少于（ ）。 ___
A. 250mm
B. 300mm
C. 350mm
D. 400mm
【单选题】
清筛时，枕心处低于枕底（ ），枕头处低于枕底150mm，枕头土垅应筛至路基面。 ___
A. 250mm
B. 200mm
C. 150mm
D. 100mm
【单选题】
清筛时，枕心处低于枕底100mm，枕头处低于枕底（ ），枕头土垅应筛至路基面。 ___
A. 100mm
B. 150mm
C. 200mm
D. 250mm
【单选题】
对枕下道床板结，道床厚度不足的线路，要清筛枕盒后起道，保持道床厚度在（ ）以上。 ___
A. 250mm
B. 300mm
C. 350mm
D. 400mm
【单选题】
当路基面存在道碎陷坑时，应一并处理，一般的做法是:通常在陷坑底部深度不少于（ ）处修筑横向渗水盲沟，以疏排陷坑内积水。 ___
A. 15~20cm
B. 20~25cm
C. 25~30cm
D. 30~35cm
【单选题】
城市轨道轨距采用国家标准，直线轨距为1435mm，曲线地段按（ ）半径给予加宽。 ___
A. 相同
B. 不同
C. 5000m
D. 6000m
【单选题】
线路轨向允许偏差应符合《铁路线路维修规则》的规定：直线方向目视顺直、无甩尾。用（ ）弦测量矢度。 ___
A. 30m
B. 20m
C. 10m
D. 5m
【单选题】
如有高低，应对直线地段两股钢轨的高低分别进行检查，检查时，先俯身目视不小于（ ）处钢轨下颚线的高低平顺情况。 ___
A. 10m
B. 20m
C. 30m
D. 40m
【单选题】
在日常检查时如高低是向上凸起者，应同时使用（ ）厚垫块，将弦的两端垫起。 ___
A. 30mm
B. 40mm
C. 50mm
D. 60mm
【单选题】
轨道在短距离范围内的轨面不平顺称之为（ ）。 ___
【单选题】
轨道在长距离范围内的轨面不平顺称之为（ ）。 ___
【单选题】
一般来说，整体道床路线，正常性的沉降，在局部范围，不可能（ ）以上的偏差。 ___
A. 20mm
B. 30mm
C. 40mm
D. 50mm
【单选题】
通过垫板作业完全能够得到解决，碎石道床线路，误差在（ ）以上时，可以采取起道作业办法，但要考虑轨面的顺坡率。 ___
A. 20mm
B. 30mm
C. 40mm
D. 50mm
【单选题】
当起道量超过（ ）时，必须申报供电系统的接触网部门予以配合。 ___
A. 20mm
B. 30mm
C. 40mm
D. 50mm
【单选题】
线路上实际存在（ ）形式的钢轨水平误差 ___
【单选题】
车轮踏面设计成（ ），踏面上有两个坡度。 ___
【单选题】
车轮踏面设计成锥形，踏面上有（ ）坡度。 ___
【单选题】
钢轨中心线与（ ）之间的倾斜度称为轨底坡。 ___
A. 竖线
B. 垂直线
C. 斜线
D. 边缘线
【单选题】
线路养护维修时，可根据光带（ ）对轨底坡进行调整。 ___
【单选题】
复曲线是由（ ）不同半径组成的曲线。 ___
A. 四个
B. 三个
C. 两个
D. 两个或两个以上
【单选题】
曲线有几个（ ）个关键控制点。 ___
A. 0.4
B. 0.5
C. 0.6
D. 0.7
【单选题】
缓和曲线的最小长度为20m，主要是从（ ）一节车辆的全轴距而确定的。 ___
【单选题】
下列情况的水沟不用采取防止冲刷或渗漏的加固措施的是（ ）。 ___
A. 流速大，可能引起冲刷的地段
B. 路堑内易产生基床病害地段的侧沟
C. 水田地区的排水沟
D. 天沟或截水沟的培堤成沟地段
【单选题】
抛石厚度一般为位径的3~4倍，用大粒径时，至少不得小于粒径的（ ）倍。 ___
A. 0.3
B. 0.2
C. 0.1
D. 0.5
【单选题】
浆砌片石护坡断面时。其施工注意事项不包括的是（ ）。 ___
A. 基础应埋人冲刷线以下0.5~1.0m，否则须有防止冲刷基础措施。
B. 墙身部分每隔2~3m设10×10cm或孔径10cm的泄水孔一个。
C. 两种不同的脚墙基础连接时，可在10m范围内逐渐变化连接
D. 在新填的土质路基边坡上砌筑，应在路基沉落稳定后进行
