【单选题】
1)H. Mario Geysen initially used parallel synthesis as a quick way to identify which small_____ of any given large protein bound to an antibody.___
A. division
B. pieces
C. part
D. fragment
查看试卷，进入试卷练习
微信扫一扫，开始刷题
相关试题
【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
推荐试题
【填空题】
13.中国梦视野宽广、内涵丰富、意蕴深远。习近平指出：“中国梦的本质是国家富强、民族振兴、人民幸福。”实现中国梦必须凝聚中国力量，这就是___
【填空题】
16.在生态文明建设方面，生态环境根本好转，美丽中国目标基本实现。清洁低碳、安全高效的能源体系和___发展的经济体系基本建立，生态文明制度更加健全。
【填空题】
1.坚持和发展中国特色社会主义总任务，是___
【填空题】
2.中国梦归根到底是人民的梦，人民是中国梦的主体，是中国梦的___
【填空题】
6.从2020年到2035年，基本实现社会主义现代化的目标要求，反映在政治建设方面，人民平等参与、平等发展权利得到充分保障，依法治国基本方略得到全面落实，___的局面基本形成
【填空题】
7.从2020年到2035年，基本实现社会主义现代化的目标要求，反映在文化建设方面，社会文明程度达到新的高度，国家文化软实力显著增强，重视___的社会风尚基本养成
【填空题】
8. 从2020年到2035年，基本实现社会主义现代化的目标要求，反映在生态文明建设方面，生态环境根本好转，美丽中国目标基本实现，___的国土开发格局形成
【填空题】
9.从2035年到本世纪中叶，建成社会主义现代化强国的目标要求，包括我国将拥有高度的精神文明，践行社会主义核心价值观成为全社会自觉行动，国民素质显著提高，___成为中国发展的重要影响力和推动力，建成文明的社会主义现代化强国
【填空题】
10.党的十九大提出了分两步走在本世纪中叶建成富强民主文明和谐美丽的社会主义现代化强国的战略安排。这一战略安排把原来我们发展战略中基本实现社会主义现代化的时间提前了15年，这是因为___
【填空题】
1.全面建成小康社会新的目标要求经济保持中高速增长，到2020年比2010年翻一番的是国内生产总值和工业增加值。___
【填空题】
2.中国梦是人民的梦，也是世界的梦，与世界的梦息息相通。___
【填空题】
3.依法治国得到全面落实，科学立法、严格执法、公正司法、全民守法的局面已经形成。___
【填空题】
4.中国梦和社会主义核心价值观深入人心，爱国主义、集体主义、社会主义思想广泛弘扬，全体人民的文化自信、文化自觉和文化凝聚力不断提高。 ___
【填空题】
5.作为负责任的大国，中国决不会称霸，决不搞扩张，中国越发展，对世界和平与发展就越有利。___
【填空题】
6.经过全党全国各族人民共同努力，我们先后提前实现了第一步、第二步战略目标，党的十七大正式宣布人民生活总体达到小康水平。 ___
【填空题】
7.改革开放40年来，我国经济持续较快发展，工业化现代化快速推进，各项事业全面进步，国家面貌发生了前所未有的巨大变化。___
【填空题】
8.国家富强，是指我国综合国力进一步增强，中国特色社会主义事业进一步发展和完善。___
【填空题】
9.民族振兴，是通过自身的不断发展与强大，继承并创造中华民族的优秀文化以及先进的文明成果，进而使中华民族再次处于世界领先地位，再次以高昂的姿态屹立于世界民族之林。___
【填空题】
10.人民幸福，就是人民权利保障更加充分、人人得享共同发展，生活在伟大祖国和伟大时代的中国人民，共同享有人生出彩的机会，共同享有梦想成真的机会，共同享有同祖国和时代一起成长与进步的机会。 ___
【填空题】
1. 面对全面建成小康社会决胜阶段复杂的国内外形势，面对经济社会发展的新趋势、新机遇和新矛盾、新挑战，党的十八届五中全会坚持以人民为中心的发展思想，鲜明提出了___的新发展理念。
【填空题】
2．贯彻新发展理念、建设现代化经济体系，要坚持质量第一、效益优先，以___为主线，推动经济发展质量变革、效率变革、动力变革，提高全要素生产率。
【填空题】
3. 中国社会主义民主政治的特有形式和独特优势是___
【填空题】
4. 从中华民族整体利益把握两岸关系大局，最根本的、最核心的是___。
【填空题】
5. 构建中国特色哲学社会科学，是掌握意识形态工作领导权的内在要求，首要的是___。
【填空题】
7. 民生是人民幸福之基、社会和谐之本。带领人民群众创造幸福生活，要顺应人民群众对美好生活的向往，坚持___的发展思想，以___为重点，发展各项社会事业。
【填空题】
8.自2016年起，每年4月15日，是我国的___。
【填空题】
9. “万物各得其和以生，各得其养以成。”生态文明的核心应该是___。
【填空题】
10. 建设生态文明是一场涉及生产方式、生活方式、思维方式和价值观念的革命性变革。要实现这样的根本性变革，必须___
【填空题】
11.面对全面建成小康社会决胜阶段复杂的国内外形势，面对当前经济社会发展新趋势、新机遇和新矛盾、新挑战，中共十八届五中全会坚持以人民为中心的发展思想，鲜明地提出了创新、协调、绿色、开放、共享的发展理念。其中，开放是___
【填空题】
12.伴随着中国特色社会主义进入新时代，我国经济已由高速增长阶段转向高质量发展阶段，正处在转变发展方式、优化经济结构、转换增长动力的攻关期。我国发展的战略目标和跨越关口的迫切要求是___
【填空题】
13.中国特色社会主义进入新时代，我国正处在转变发展方式、优化经济结构、转换增长动力的攻关期。经济已经由___
【填空题】
14.中华人民共和国成立以来，中国共产党领导的多党合作和政治协商制度的重要性不断增强。实践证明，这一制度能够在中国特色社会主义共同目标下把中国共产党领导和多党派合作有机结合起来，实现广泛参与与集中领导、社会进步与国家稳定、充满活力与富有效率的统一。在这一制度中，多党合作的首要前提和根本保证是___
【填空题】
15.解决台湾问题、实现祖国完全统一，是全体中华儿女共同愿望，是中华民族根本利益所在。中共十八大以来，在以习近平同志为核心的党中央的坚强领导下，在两岸同胞共同努力下，两岸关系取得了重要成果。两岸关系和平发展的政治基础是___
【填空题】
16.随着经济的快速发展和物质生活水平的提高，人们的精神文化需求日益增长，迫切要求通过深化文化体制改革，激发文化发展的活力，为人民群众提供更多更好的文化产品和文化服务，保障人民的基本文化权益。保障人民基本文化权益的主要途径是___
【填空题】
17.深化文化体制改革，要坚持公益性文化事业和经营性文化产业协调发展。发展经营性文化产业的根本任务是___
