【单选题】
1)H. Mario Geysen initially used parallel synthesis as a quick way to identify which small_____ of any given large protein bound to an antibody.___
A. division
B. pieces
C. part
D. fragment
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【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
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【单选题】
节系统称为___。
A. 串级调节
B. 比例调节
C. 分程调节
D. 均匀调节
【单选题】
由于流体在导管横截面上各点的流速并不相同，越接近管中心处流速___，越接近管壁处流速（ A ）。
A. 越大越小
B. 越小越大
C. 越小越小
D. 越大越大
【单选题】
氢气产品中乙炔含量应小于___
A. 1PPM（mol）
B. 5 PPM（mol）
C. 10 PPM（mol）
D. 20 PPM（mol）
【单选题】
R-401床层温度SD-1联锁值为___℃
A. 100℃
B. 80℃
C. 60℃
D. 120℃
【单选题】
裂解气再生是利用干燥剂在___的原理。
A. 在高温低压下释放水分
B. 低温高压下吸附水分
C. 高温高压下吸附水分
D. 在低温高压下释放水分
【单选题】
精馏塔塔压联锁的原因是___。
A. 加热量提得太快
B. 回流量太大
C. 进料量增大
D. 塔釜采出量太少
【单选题】
影响脱甲烷塔乙烯收率的重要因素是，操作温度和压力、___
A. 甲烷/氢比
B. 塔顶冷剂
C. 灵敏板温度
D. 进料中甲烷量
【单选题】
控制高压甲烷中乙烯含量的目的不包括___
A. 保证甲烷产品质量
B. 减小乙烯损失
C. 提高乙烯收率
D. 降低冷箱温度
【单选题】
脱丁烷塔T-405在___停车
A. 热区停车前
B. 丙烯精馏塔停车后
C. 低压脱丙烷塔停车后
D. 低压脱丙烷塔停车前
【单选题】
设备倒空的先后顺序为___
A. 先泄压，后排液
B. 先倒液，后泄压
C. 泄压倒液同时进行
D. 无先后次序
【单选题】
屏蔽泵启动时候，其出入口阀的状态为___
A. 入口开，出口关
B. 入口开，出口开
C. 入口关，出口关
D. 入口开，出口稍开
【单选题】
精馏塔开车的过程中，首先要稳定的参数是___
A. 塔压
B. 塔顶温
C. 进料
D. 灵敏板温度
【单选题】
脱丁烷塔T-405塔釜再沸器的切换，出现塔釜液位下降过快，可能出现的原因是___
A. 气相开的太快
B. 气相阀开得太大
C. 液相阀开得太快
D. 液相阀开得太大
【单选题】
下列选项中，属于阻聚剂泵不上量的原因是___
A. 冲程太大
B. 泵入口过滤网堵塞
C. 泵油位过高
D. 阻聚剂罐位设定过高
【单选题】
精馏塔出现冻塔后，下列描述正确的是___
A. 塔压差高
B. 塔温度分部正常
C. 回流罐液位稳定
D. 塔釜液位稳定
【单选题】
脱乙烷塔T-401塔底再沸器加热介质___
A. 盘油
B. 急冷水
C. 丙烯
D. 低压饱和蒸汽
【单选题】
预脱甲烷塔T-302塔底再沸器加热介质___
A. 盘油
B. 急冷水
C. 丙烯
D. 低压饱和蒸汽
【单选题】
高压脱丙烷塔T-201塔底再沸器加热介质___
A. 盘油
B. 急冷水
C. 丙烯
D. 低压饱和蒸汽
【单选题】
脱丁烷塔T-405塔底再沸器加热介质___
A. 盘油
B. 急冷水
C. 丙烯
D. 低压饱和蒸汽
【单选题】
分离岗位塔板数最多，回流比最大的塔是___。
A. 脱甲烷塔
B. 乙烯精馏塔
C. 丙烯精馏塔
D. 脱丙烷塔
【单选题】
甲烷化反应器R-301如果操作暂时中断时应保证床层温度不低于___℃,防止在低温下剧毒的羰基镍产生。
A. 130
B. 140
C. 150
D. 160
【单选题】
碳二加氢反应器R-201SD-1联锁报警值___℃。
【单选题】
碳二加氢反应器R-201SD-1联锁值___℃。
【单选题】
乙烯装置使用氮气纯度为___。
A. 90.0%(体)
B. 95%(体)
C. 99.5%(体)
D. 99.9%(体)
【单选题】
冷箱是由许多___组成的。
A. 列管式换热器
B. 板翅式高效换热器
C. 组列管式和夹套式换热器
D. 夹套式换热器
【单选题】
冷箱一般是由___板翅式换热器串联或并联而成。
【单选题】
外部管道与冷箱的联接一般采用___。
A. 铜法兰
B. 铝法兰
C. 不锈钢法兰
D. 碳钢法兰
【单选题】
冷箱壳体充氮气是为了防止___进入。
A. 湿空气
B. 氮气
C. 一氧化碳
D. 二氧化碳
【单选题】
___运用的不是焦耳—汤姆逊效应。
A. 氢气经过冷箱回收冷量
B. 低压甲烷经冷箱回收冷量
C. 氢气开工线的投用
D. 中压甲烷经冷箱回收冷量
【单选题】
关于冷箱中流体甲烷的节流膨胀，下列说法正确的是___。
A. 等焓膨胀，压力降越大，节流后温度越高
B. 等焓膨胀，压力降越大，节流后温度越低
C. 等熵膨胀，压力降越大，节流后温度越高
D. 等熵膨胀，压力降越大，节流后温度越低
【单选题】
冷箱系统氢气开工线是指___。
A. 氢气节流到高压甲烷中
B. 氢气节流到低压甲烷中
C. 氢气节流到中压甲烷中
D. 氢气节流后去火炬系统
【单选题】
深冷顺序分离流程中，冷箱可以分离出的物料有___。
A. 氢气
B. 氢气和甲烷
C. 甲烷
D. 甲烷和乙烯
【单选题】
分离前冷流程中，氢气经冷箱回收冷量后送往___。
A. 甲烷化系统
B. 碳二加氢系统
C. 碳三加氢系统
D. 汽油加氢系统
【单选题】
粗氢中乙烯含量主要通过___来保证的。
A. 脱甲烷塔顶温
B. 冷箱第一气液分离罐的温度
C. 氢气甲烷分离罐的温度
D. 冷箱第二气液分离罐的温度
【单选题】
冷箱系统分离出来的氢气纯度主要取决于___。
A. 脱甲烷塔第一进料分离罐的温度
B. 脱甲烷塔第二进料分离罐的温度
C. 脱甲烷塔第三进料分离罐的温度
D. 氢气甲烷分离罐的温度
【单选题】
裂解气中乙炔对分离系统的影响是___。
A. 乙炔浓度高，易造成冷箱堵塞
B. 乙炔能使甲烷化反应器催化剂中毒
C. 乙炔浓度高低会影响脱甲烷塔的正常操作
D. 乙炔对碳二加氢催化剂不利
【单选题】
ARS技术的核心是采用了高效、节能的___。
A. 分凝分离器
B. 冷箱
C. 双脱甲烷塔
D. 先进回收系统
