【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
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【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
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___和（）应根据现场的安全条件、施工范围、工作需要等具体情况，对有触电危险、施工复杂、容易发生事故的工作，增设专责监护人
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装卸高压熔断器，应戴___
A. 护目镜
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装卸高压熔断器，必要时使用绝缘夹钳，并站___和（）上
A. 水泥地面
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下列各项工作可不用操作票___
A. 事故应急处理
B. 拉合断路器单一操作
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线路停、送电均应按照___的指令执行
A. 值班调度员
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D. 运行值班员
【多选题】
六氟化硫设备检修人员需穿着防护服并根据需要佩戴___
A. 口罩
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六氟化硫配电装置发生防爆膜破裂时，应停电处理，并用___擦拭干净
A. 水泥地面
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SF断路器检修工作结束后，检修人员应洗澡，把使用过的___清洗干净
A. 工器具
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在低压配电装置的工作，低压回路停电停电的安全措施：停电、验电、接地、___
A. 悬挂标示牌
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C. 绝缘遮蔽
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【多选题】
在低压配电装置的工作，低压回路停电更换断路器，恢复操作时，应戴___
A. 安全帽
B. 手套
C. 护目镜
D. 单工帽
【多选题】
在低压配电装置的工作时，低压工作，应采用有效措施遮蔽有电部分防止___
A. 相间短路
B. 接地短路
C. 单相接地
D. 接地
【多选题】
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A. 运行设备
B. 检修设备
C. 设备与围栏
D. 保护接地
【多选题】
在带电的电流互感器二次回路上工作时，应采取安全措施，短路电流互感器绕组，应采用___
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B. 短路线
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A. 放电
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使用电压互感器工作时应戴___，站在绝缘垫上，并应有专人监护
A. 安全帽
B. 手套
C. 护目镜
D. 口罩
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使用钳形电流表测量电流观测表计时，要特别注意___安全距离
A. 头部
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带电作业要求，___认为有必要时，应组织到现场勘察
A. 施工单位
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在带电的电压互感器二次回路上工作时，应采取安全措施，严格防止___
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工作场所的照明，应该保证足够的亮度。在操作盘、重要表计、___、机房等地点，还应设有事故照明。
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工作票应使用黑色或蓝色钢（水）笔或圆珠笔填写与签发，一式两份，内容应正确，填写应清楚，不得任意涂改
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一张工作票中，工作票签发人、工作负责人和工作许可人三者可以互相兼任
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