【单选题】
It is really helpful to have someone like you that we can ___ and count on during difficult times.
A. lean on
B. get to
C. hang on
D. get by
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相关试题
【单选题】
Women have a greater ability to ___ names with faces than men do, and they are also better at recalling lists.
A. associate
B. compare
C. engage
D. involve
【单选题】
He was always ready to help others and managed to ___ his friends ____being hurt.
A. expose … to
B. confine …to
C. restrict … from
D. shield … from
【单选题】
Older people are less likely to be ___ their negative emotions (情绪) and more likely to focus on the positive.
A. reserved for
B. caught up in
C. beat up to
D. counted on
【单选题】
I don’t have any bandage, so I have to ___ pressure to the wound to keep the bleeding down.
A. apply
B. involve
C. fulfill
D. establish
【单选题】
It is important that whichever candidate (候选人) is picked the loser should accept the defeat ___.
A. in advance
B. with great pride
C. with good grace
D. in large part
【单选题】
___ that new homes cost more than older homes, but that is not true across the country anymore.
A. It used to be
B. It is used to be
C. It used to being
D. It is used to being
【单选题】
The boss ___ his employees to work longer hours as the company is dreadfully short of staff at present.
A. called on
B. signed up
C. cared for
D. set up
【单选题】
The president’s visit and ___ discussions led to a plan that aimed to improve the trade relations between the two countries.
A. emerging
B. subsequent
C. consequent
D. Submerging
【单选题】
The author ___ his general idea mainly through statistics and results obtained from a survey (调查) about auto customer services in the United States.
A. assumes
B. engages
C. illustrates
D. represents
【单选题】
People in this town starved, several buildings were bombed and crime ___ because you had to steal to eat.
A. eroded
B. reflected
C. released
D. soared
【单选题】
Olympic recognition for bodybuilding (健美) remains ___ since some argue that bodybuilding is not a sport because the actual contest does not involve the same sort of efforts as “real” sports.
A. controversial
B. conventional
C. characteristic
D. influential
【单选题】
Tom tried to justify his absence from the meeting by ___ that he had been ill that day.
A. admitting
B. advocating
C. claiming
D. citing
【单选题】
___ the huge financial benefits, biological companies have been rushing to set up laboratories and new research projects.
A. Aware
B. Aware of
C. Not aware
D. Not aware of
【单选题】
Unfortunately, ___ lack of funds, the studies he began just two months ago, had to be ended early.
A. out of
B. in addition to
C. owing to
D. to begin with
【单选题】
With a good command of English, he soon got ___ to working with British people.
A. accustomed
B. consistent
C. relevant
D. responsible
【单选题】
What needs to be ___ here is that language and culture interact, and that understanding of one requires understanding of the other.
A. altered
B. stressed
C. aroused
D. committed
【单选题】
Policies and organizations must be created to meet workers’ hopes, and to ___ new problems that inevitably arise between workers and managers.
A. compromise
B. ensure
C. undermine
D. resolve
【单选题】
To keep the wheels of industry turning, we produce consumer goods in endless quantities, and, in the process, are rapidly ___ our natural resources.
A. ignoring
B. collapsing
C. enduring
D. exhausting
【单选题】
As a person who loves peace, he is committed ___ realizing peace between countries.
A. of
B. about
C. for
D. to
【单选题】
Learning how to use chopsticks is easy for me, ___ learning how to conduct myself at the table is quite difficult.
A. whereas
B. however
C. therefore
D. besides
【单选题】
___ that the patient smokes 50 cigarettes a day, it would be reasonable to assume there is some lung damage.
A. To give
B. Giving
C. Given
D. Having given
【单选题】
Kenyan (肯尼亚的) women tend to vote for those who could provide them ___ the necessary food to live on.
A. of
B. with
C. for
D. about
【单选题】
___ all obstacles and failures, the scientist continued doing his experiments day and night.
A. In spite of
B. In contrast to
C. As a matter of
D. As a result of
【单选题】
I’m willing to ___ that a larger car would have cost more, but I still think we should have bought one.
A. withdraw
B. indicate
C. abandon
D. concede
【单选题】
Manufacturing (制造) companies spend millions of pounds on advertisements, trying to ___ customers that their products are better than those of other companies.
A. confine
B. convince
C. depress
D. reconcile
【单选题】
He is not the right person for the project: he is not very technically minded and ___, he does not have the sense of responsibility.
A. instead
B. yet
C. furthermore
D. nevertheless
【单选题】
Death rates declined in many places, partly because of the ___ in hunger.
A. decrease
B. myth
C. obstacle
D. burden
【单选题】
In deciding whether or not a situation is safe, pilots must be taught to assume that the worst will happen, and then to ___ whether there is a risk or not.
A. absorb
B. apply
C. assess
D. occupy
【单选题】
The worker was not worried as he knew that if he gave up the job, there would be ___ opportunities for him to work somewhere else.
A. formative
B. marginal
C. vigorous
D. numerous
【单选题】
The research shows the region might ___ overheating (经济过热), but the policymakers so far appear to be relatively relaxed about the future of the economy.
A. catch a glimpse of
B. be at risk of
C. take a toll on
D. be free from
【单选题】
Measures have been taken to ensure that no student will have to ___ of college for economic reasons.
A. lay out
B. cancel out
C. drop out
D. stand out
【单选题】
Stress that is not treated can lead to significant medical illnesses, which ___ can lead to greater stress and even depression (抑郁症).
A. after all
B. in turn
C. on the contrary
D. at least
【单选题】
Narcissism (自恋) has its benefits in terms of self-belief and confidence, but it also tends to be ___ risky decision-making.
A. associated with
B. contrasted with
C. reserved for
D. relieved of
【单选题】
When Tom saw his doctor again, she suggested that maybe a more substantial lunch, like a sandwich, might ___ his desire to have snacks in the afternoon.
A. count on
B. cut back on
C. hold on to
D. contribute to
【单选题】
You shouldn’t ___ – let your children make their own decisions.
A. interact
B. abuse
C. startle
D. interfere
【单选题】
This is a huge and difficult project and if you take it up, you ___ many difficulties.
A. like to encounter
B. like encountering
C. are likely to encounter
D. are like to encounter
【单选题】
The ability to live for a long time without water is characteristic ___ the camel.
A. of
B. for
C. about
D. in
【单选题】
Rising sales is a good ___ that this product is well received in the market.
A. response
B. convention
C. indication
D. Influence
【单选题】
When tourists travel abroad, they are sometimes ___ by the local people because the tourists don’t know the real value of products.
A. turned in
B. given chase
C. wrapped up
D. ripped off
【单选题】
The professor’s lecture ___ the capacity of his young audience. They all looked puzzled at him.
A. pointed out
B. went beyond
C. contributed to
D. kept off
推荐试题
【多选题】
ENESTnd研究landmark分析中，达希纳300mg BID治疗第五年哪组患者的结局百分率为97%？
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究随访五年时，以下哪个研究终点，达希纳300mg BID 和伊马替尼组之间反应差异率为23%？
A. MMR
B. MR4.0
C. MR4.5
D. MR5.0
【多选题】
ENESTnd研究中，达希纳300mgBID组中获得MR4.5的患者在60个月时发生疾病进展的人数为（ )。
【多选题】
ENESTnd研究中，达希纳累积MR4.5率与伊马替尼相比的结果是（ ）。
A. 达希纳持续优于伊马替尼
B. 伊马替尼优于达希纳
C. 结果无差别
D. 以上均不正确
【多选题】
ENESTnd研究中，达希纳体现了良好的耐受性，48个月时达希纳300mg BID组患者的实际用药剂量达预期剂量的（ ）。
A. 0.8
B. 0.85
C. 0.9
D. 0.99
【多选题】
ENESTnd研究中，达希纳一线治疗6年累积达到MR4.5的患者比例为
A. 0.49
B. 0.52
C. 0.56
D. 0.58
【多选题】
ENESTnd研究中，达希纳与格列卫一线治疗6年累积达到MR4.5的患者比例的差值
A. 逐渐缩小
B. 逐渐增大
C. 基本不变
D. 先增大后缩小
【多选题】
ENESTnd研究中，达希纳组患者维持在慢性期的比例是（ ）。
A. 0.9
B. 0.85
C. 0.99
D. 0.8
【多选题】
ENESTnd研究中，达希纳组疾病进展（ ）伊马替尼组。
A. 低于
B. 高于
C. 等于
D. 以上均不正确
【多选题】
ENESTnd研究中，随访5年，达希纳一线治疗组疾病进展至AP/BC的患者数与伊马替尼相比，显著更少，分别为（ ）例和（ ）例。
A. 5，5
B. 6，7
C. 2，12
D. 8，9
【多选题】
ENESTnd研究中，伊马替尼治疗CML患者发生突变比达希纳治疗的患者多
A. 1.5倍
B. 2倍
C. 2.5倍
D. 3倍
【多选题】
"ENESTnd研究中，伊马替尼组MR4.5累积率不及达希纳治疗组，并且持续证实了MR4.5率比达希纳组更低的随访时间为
【多选题】
ENESTnd研究中，在发生突变的患者中，伊马替尼治疗出现治疗失败的患者数量为达希纳治疗的
A. 2倍
B. 2.5倍
C. 3倍
D. 4倍
【多选题】
ENESTnd研究中接受达希纳300 mg BID 治疗3个月时达到EMR的中度SOKAL风险患者的比例为
A. 0.89
B. 0.9
C. 0.91
D. 0.92
【多选题】
ENESTnd研究中接受达希纳治疗的患者在6年内未进展至AP/BC的比例为
A. 0.87
B. 0.61
C. 0.59
D. 0.99
【多选题】
ENESTop研究中，在符合严格的TFR尝试资格标准的患者中，停药144周后仍可保持TFR(无MMR丢失或MR4确认丢失)的患者比例为
A. 0.189
B. 0.237
C. 0.376
D. 0.484
【多选题】
ENESTop研究中MMR丢失或MR4确认丢失后重新启动后，每月监测一次，直到以前的MMR或MR4重新建立，此后监测时间为
A. 每4周一次
B. 每6周一次
C. 每12周一次
D. 每半年一次
【多选题】
ENESTswift 研究中大约三分之一的患者在因对伊马替尼或达沙替尼耐受不良而改用达希纳3个月后达到
A. 无MMR
B. MMR
C. MR4
D. MR4.5
【多选题】
ENESTxtnd研究中，一线达希纳300mg BID治疗反应欠佳或治疗失败后患者允许增加剂量至
A. 350 mg BID
B. 400 mg BID
C. 450 mg BID
D. 500 mg BID
【多选题】
ENESTxtnd研究中，一线达希纳治疗反应欠佳或治疗失败后增加剂量治疗后患者24个月内达到MMR的比例超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4的患者比例为
A. 0.54
B. 0.64
C. 0.73
D. 0.88
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者，（ ） 患者回复至慢性期。删除
A. 0.7
B. 0.85
C. 0.9
D. 0.96
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者，CHR持续率和CCyR持续率率可达（ ） 。
A. 0.56
B. 0.81
C. 56%和81%
D. 81%和56%
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者的7年OS达（ ）。
A. 0.43
B. 0.3
C. 0.23
D. 0.17
【多选题】
ICH是指（ ）。
A. 欧洲药品管理局
B. 国际协调会议
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
ICH指南推荐：如果药物有不同的晶型，应选择（ ） 的晶型。
A. 最多
B. 最常见
C. 热力学最稳定
D. 最易获得
【多选题】
IRIS研究中，伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
"PCR检测BCR-ABL mRNA转录，是灵敏度最高的检测方法，能在（ ） 细胞中检测出1个异常细胞。
A. 1000个
B. 1万个
C. 10万个
D. 100万个
【多选题】
Ph+CML的治疗和监测的发展主要是基于其特征性基因缺陷: （ ）。
A. Src
B. BCR-ABL
C. PDGFR
D. KIT
【多选题】
Ph+CML慢性期患者因换用α晶型仿制品而导致的生存期下降模型显示，格列卫换用α晶型仿制品治疗最差的情况下，患者质量调整生存年仅有（ ） 。
A. 13.44年
B. 1.8年
C. 9.57年
D. 5年
【多选题】
Ph+CML治疗中非常重要，是多数停药试验入组的必要条件。
A. 血液学反应
B. 细胞遗传学反应
C. 分子学反应
D. 更深的分子学反应（MR4.5）
【多选题】
RT-PCR能够在（ ）。
A. 20到25个细胞中检出1个白血病细胞
B. 200到500个细胞中检出1个白血病细胞
C. 2000到5000个细胞中检出1个白血病细胞
D. 10万到100万个细胞中检出1个白血病细胞
【多选题】
RT-Q-PCR非标准化是（ ）造成的。
A. 由于方法学和报告不同，导致结果各异
B. 每个患者的结果伴随一定程度的时间波动
C. 实验室间的结果比较不可行
D. 以上所有选项
【多选题】
Sokal评分是CML预后评估的一种方式，Sokal评分（ ）是高危患者？
A. Sokal评分<0.8
B. Sokal评分在0.8~1.2之间
C. Sokal评分>1.2
D. 以上均不正确
【多选题】
X-射线粉末衍射所示—α晶型和β晶型（ ）。
A. 存在差异
B. 不存在差异
C. 没有差异
D. 以上所有选项均错误
【多选题】
α晶型仿制品不仅稳定性差，还普遍存在（ ） 含量超标。
A. 遗传学毒性杂质
B. 活性成分
C. 选项1和2
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼（ ） 格列卫。
A. 就是
B. 不等于
C. 优于
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼处于（ ） ，可能向β晶型转变。
A. 高能态
B. 低能态
C. 稳定态
D. 以上所有选项均错误
