【单选题】
Q2: When did the man first do a triathlon?___
A. Last year .
B. In college .
C. Last week .
D. In high school .
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【单选题】
Q3: How does the man feel about running?___
A. Boring.
B. Scaring .
C. Exciting .
D. Interesting .
【单选题】
Q4: Why doesn’t the woman like swimming in the triathlon?___
A. Because she fears that a big fish might eat her .
B. Because she fears that she would get lost in lakes .
C. Because she doesn't want to scare away small fishes .
D. Because she doesn't like swimming with many people .
【单选题】
Q1: What is the ratio of positive to negative emotions that can make a person happier?___
A. 1:3.
B. 3 :1.
C. 1 :10 .
D. 10 :1.
【单选题】
Q2: What is the most exciting finding about increasing positive emotions?___
A. It improves relationships .
B. It leads to greater success .
C. It helps develop creativity .
D. It contributes to good health .
【单选题】
Q3: What does the speaker say about negative feelings?___
A. People should turn every negative feeling around .
B. Negative feelings can sometimes have positive effects .
C. Negative feelings often cause people to make mistakes .
D. People should never show negative feelings in public places .
【单选题】
Q4: What is the main idea of the passage?___
A. People should learn to manage their emotions .
B. People should be patient with their negative feelings .
C. People should learn to analyze causes of unhappiness .
D. People should identify as many positive feelings as possible .
【单选题】
Q1: What are the man and woman talking about?___
A. Whether nature is magical and kind .
B. Whether nature is powerful and full of risks .
C. Whether Christopher was well prepared for the trip .
D. Whether Christopher's trip to Alaska was worthwhile .
【单选题】
Q2: What can we learn about Christopher?___
A. He made a film about his trip to Alaska .
B. He wrote a story about his trip to Alaska .
C. He died while having an adventure in Alaska .
D. He learned how powerful and risky Alaska was .
【单选题】
Q3: What does the woman think about Christopher taking the trip to Alaska?___
A. He was too foolish .
B. He was really romantic .
C. He had a very kind heart .
D. He had a spirit for trying things .
【单选题】
Q4: Which of the following is NOT mentioned as something that would have saved Christopher’s life?___
A. A gun to hunt .
B. The map of the area .
C. Emergency food supplies .
D.
E. mergency communication equipment .
【单选题】
Q1: What speed can an avalanche reach within five seconds of taking off?___
A. At 8 miles an hour .
B. At 18 miles an hour .
C. At 80 miles an hour .
D. At 88 miles an hour .
【单选题】
Q2: According to the passage, under what circumstances may an avalanche occur?___
A. There are too many layers of snow on the .
B. There is a layer of snow covering an entire area .
C. The top layer of snow slides off the layer below it .
D. The layer of snow below the surface becomes unstable .
【单选题】
Q3: What are skiers advised to do to avoid being caught in an avalanche?___
A. Ski only in the official ski areas .
B. Look for solid snow to walk on .
C. Look out for each other while skiing .
D. Learn to control themselves in an avalanche .
【单选题】
Q4: Why does the ski patrol use explosives?___
A. To dig holes in the snow .
B. To close the area for skiing .
C. To make an avalanche move on purpose .
D. To' check how different layers are holding up .
【单选题】
Q1:What is conversation mainly about?___
A. The woman's happy college life the man's doubt .
B. The woman's spending habits and the man's concerns .
C. The man's reminding the woman of the exam this Thursday .
D. The man's support for the woman over the past 15 years .
【单选题】
Q2:What did the woman do last night?___
A. She bought a new leather coat .
B. She studied very hard for an exam .
C. She treated all her friends to dinner .
D. She went to a concert with her friends .
【单选题】
Q3:Where did the woman get the money?___
A. She just received her student loan .
B. She saved some money for herself .
C. She borrowed the money from her friends .
D. She asked her mom to send her the money .
【单选题】
Q4:What is the man?___
A. A teacher of biology .
B. An undergraduate student .
C. A freshman in biology class .
D. A graduate teaching assistant .
【单选题】
Q1: What is this passage mainly about?___
A. How businesses can compete with each other .
B. How small businesses operate during holidays .
C. How small businesses manage holiday workers .
D. How can earn more money during holidays .
【单选题】
Q2: According to Rubin, what can small companies do to thank holiday workers?___
A. Have talks with their families .
B. Give them good extra benefits .
C. Offer them expensive holiday tokens .
D. Show appreciation to them face to face .
【单选题】
Q3: What can small business owners do to help holiday workers get into the holiday spirit?___
A. Entertain them with big meals .
B. Let them enjoy some holiday games .
C. Give them handmade thank-you cards .
D. Send their families some holiday gift cards .
【单选题】
Q4: Who are supposed to benefit most from this passage?___
A. Workers who have to work during holidays .
B. Employees who intend to earn extra money .
C. Big companies that usually close on holidays .
D. Small businesses that try to be more competitive .
【单选题】
In the first two paragraphs of the passage the writer tries to tell us that___
A. he had lived in Washington D.C. for twenty years
B. he was very imaginative when he was a child
C. he had fond memories of his old neighborhood
D. )he had come from a very poor neighborhood
【单选题】
The writer ,as a child ,was very fond of playing in the basement because ___
A. it was bright and alive
B. it contained a movie house and a space station
C. it was ideal for playing hide-and-seek
D. it was surrounded by trees and flowers
【单选题】
How did the writer feel when he visited his old neighborhood in Washington D.C. ?___
A. Greatly surprised .
B. Very regretful .
C. Quite excited .
D. Very sad .
【单选题】
On his visit to his hometown ,the writer found the old apartment building___
A. see medunfit to live in
B. had been repaired
C. could hardly be recognized
D. looked dirty and smelt horrible
【单选题】
" Youcan never go home again "inthe last sentence of this passage means that___
A. one should never revisit his hometown after many years of absence
B. one will never find his hometown the same as it was in his childhood memory
C. avisit to one's hometown will bring back one's fond memories of home
D. avisit to one's hometown will bring back many sad memorie
【单选题】
We learn from the passage that Tracy died___
A. on December 8,1992
B. of brain damage
C. 24 hours after he fell off the roof of a car
D. in a car crash
【单选题】
Tracy's parents decided to donate Tracy's organs because___
A. Tracy told them to do so just before he died
B. they wanted to save others the pain of seeing a dear one die
C. David's life could continue in a meaningful way
D. they knew David was suffering from a hopeless liver disease
【单选题】
The meeting between the writer's family and Tracy's parents was arranged because___
A. the writer and her husband wished to express their thanks to Tracy's parents
B. the local organ bank wanted to see how both families felt about the donation
C. Tracy's parents wanted to see someone whose life had been saved by the donation
D. the two families were linked by the most bittersweet ties imaginable
【单选题】
The writer and her husband learned how Tracy died___
A. from his parents
B. from the organ bank
C. from the hospital
D. from the doctor who performed the operation
【单选题】
The meeting between the two families helped to ease the Marshes'suffering because___
A. they saw that David looked very much like their son
B. they saw that David had regained health with Tracy's liver
C. they now had someone to share their memories of Tracy
D. they now knew for sure they had done the right thing
【单选题】
The writer's first marriage was unsuccessful because___
A. her husband often woke her up at midnight
B. her husband kept criticizing her
C. she was so unattractive
D. she had a self-esteem problem
【单选题】
When the writer asked for a divorce ,her husband___
A. told her that she would never find one who loved her as he did
B. delayed two years before giving her a reply
C. accused her of having an affair
D. said that she was unattractive and not worth loving
【单选题】
When the writer first met Clint ,she felt that___
A. she should have listened to her friend and met Clint earlier
B. Clint was a nice ,dazzling young man
C. Clint could not be really interested in her
D. she would find true love in Clint
【单选题】
The writer was particularly touched by Clint because___
A. he loved her children and asked for their approval of the marriage
B. he said that he could not imagine a life without her and the children
C. he believed that at 2 and 4 ,the two children were the "menof the house "
D. hekept her company and talked with her until the next morning
【单选题】
The writer's marriage to Clint is important to her mainly because___
A. it gave her and her sons a second chance to live a happy life
B. every day Clint would tell the writer that he loved her
C. it helped her to regain her self respect
D. it made her children happy ,which is all she cared about in life
【单选题】
What was Goodall's childhood dream ?___
A. She dreamed of going to college .
B. She dreamed of studying animals in Africa .
C. She dreamed of becoming a scientist .
D. She dreamed of traveling all around the world .
【单选题】
What did Goodall's mother think of her dream ?___
A. As a girl she should not go to the African jungle .
B. Her dream would remain a dream unless she got the right training .
C. As a girl she should stay away from violent animals .
D. She could make her dream come true if she was determined .
【单选题】
Goodall's most important discovery was that___
A. some animals use tools
B. like humans animals have emotions
C. chimpanzees could attack each other violently
D. termites are chimpanzees'favorite food
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【多选题】
以下哪个不是达希纳常见的不良反应？
A. 皮疹
B. 胆红素增高
C. 胸腔积液
D. 骨髓抑制
【多选题】
以下哪个生化异常会增加心脑血管事件发生？
A. 胆红素和脂类升高
B. 血糖和脂类降低
C. 血糖和脂类升高
D. 胆红素和血糖降低
【多选题】
以下哪个是心脑血管疾病不可改变的危险因素？
A. 高血压
B. 性别
C. 糖尿病
D. 吸烟
【多选题】
以下哪个是心脑血管疾病的可改变的危险因素？
A. 糖尿病
B. 性别
C. 年龄
D. 家族史
【多选题】
应用达希纳期间，可能出现QT间期延长，在（ ）检查ECG监测QT间期？
A. 开始给药前
B. 给药后7天
C. 以及有临床指征时
D. 以上所有选项
【多选题】
有研究表明，格列卫换用α晶型仿制品治疗，（ ） 明显更低。
A. 无进展生存期
B. 总生存期
C. 质量调整生存年
D. 以上所有选项
【多选题】
有研究表明，格列卫换用α晶型伊马替尼治疗，患者（ ） 。
A. 疾病进展
B. 疗效丧失
C. 不良反应严重
D. 以上所有选项
【多选题】
有研究表明，格列卫换用α晶型伊马替尼治疗3个月，17%的患者快速进展至（ ）。
A. 慢性期
B. 加速期
C. 急变期
D. 选项2和3
【多选题】
有研究表明，格列卫一线治疗CML-BC患者长期生存率（ ）。
A. 高
B. 低
C. 未知
D. 以上所有选项均错误
【多选题】
有研究表明，格列卫治疗CML-BC患者，（ ） 患者回复至慢性期。
A. 0.75
B. 0.68
C. 0.55
D. 0.5
【多选题】
越早获得（ ）意味着获得（ ）机会越大?
A. MMR，CMR
B. CMR，CMR
C. MMR，MMR
D. CMR，MMR
【多选题】
在2101研究中，CML患者换用达希纳后48个月时PFS估计率为
A. 0.5
B. 0.57
C. 0.6
D. 0.63
【多选题】
在ENEST1st研究中，接受达希纳治疗的患者在3个月时达到EMR的比例为
A. 0.93
B. 0.95
C. 0.97
D. 0.99
【多选题】
在ENESTnd研究随访5年时，在接受达希纳300 mg BID治疗的患者中感染发生率低于
A. 0.05
B. 0.1
C. 0.15
D. 0.2
【多选题】
在ENESTnd研究中，无论SOKAL风险如何，伊马替尼治疗的CML患者12个月时未达到MMR的比例超过
A. 0.4
B. 0.5
C. 0.6
D. 0.7
【多选题】
在ENESTnd研究中，伊马替尼治疗组疾病进展至AP/BC的患者是达希纳治疗组的
【多选题】
在ENESTnd研究中接受伊马替尼治疗3个月的高度SOKAL风险患 者未达到EMR比例超过
A. 0.56
B. 0.44
C. 0.3
D. 0.21
【多选题】
在ENESTop研究TFR过程中使用的监测要求为如果MMR丢失或MR4确认丢失(连续测量2次，间隔4周，显示MR4丢失)，达希纳重新启动于
A. 2周内
B. 4周内
C. 3个月内
D. 1年内
【多选题】
在NOVEL研究中，因AEs中断伊马替尼治疗的患者在换用达希纳后AEs缓解的比例为
A. 0.6
B. 0.72
C. 0.79
D. 0.84
【多选题】
在二代TKI选择时，可以参照BCR-ABL激酶域突变类型选择药物，如患者是F317L/V/I/C、V299L、T315A突变采用（ ）治疗更易获得临床疗效？
A. 达希纳
B. 施达赛
C. 以上均正确
D. 以上均不正确
【多选题】
在服用达希纳最初的2个月，由于骨髓抑制，应每隔（ ）做一次全血细胞计数，之后可每（ ）检测一次，或者在有临床指征时进行。
A. 2周，1个月
B. 1周，2个月
C. 3周，1个月
D. 2周，2个月
【多选题】
在格列卫治疗出现的33种突变中，达希纳能够有效抑制其中种突变？
A. 15种突变
B. 20种突变
C. 32种突变
D. 33种突变
【多选题】
在既往TKI研究中，DASISION研究应用（ ） 进行风险评分。
A. sokal
B. Hasford
C. EUTOS
D. SAPS
【多选题】
在既往TKI研究中，ENEST1st研究应用（ ）进行风险评分。
A. sokal
B. Hasford
C. EUTOS
D. SAPS
【多选题】
在既往TKI研究中，IRIS、ENESTnd等研究都应用（ ）进行风险评分。
A. sokal
B. Hasford
C. EUTOS
D. SAPS
【多选题】
在研究2101中，换用达希纳400 mg BID后大多数获得反应的患者达到 Ph+ < 35%的时间为
A. 1个月内
B. 3个月内
C. 6个月内
D. 12个月内
【多选题】
早期分子学反应，意味着随后获得的MMR率会（ ）。
A. 更高
B. 更低
C. 无影响
D. 不确定
【多选题】
早期分子学反应，意味着随后获得深层分子学（MR4.5）率会（ ）。
A. 更高
B. 更低
C. 无影响
D. 不确定
【多选题】
中国CML诊疗指南推荐，CML-AP/BC患者初始接受（ ） 治疗。
A. 伊马替尼400 mg QD
B. 伊马替尼600 mg QD
C. 伊马替尼400 mg BID
D. 伊马替尼600 mg BID
【多选题】
中国CML诊疗指南推荐，CML-AP/BC患者经伊马替尼治疗后回复至慢性期，后续可接受（ ）治疗。
A. 继续应用伊马替尼治疗
B. 干细胞移植（如可行）
C. 继续应用伊马替尼或干细胞移植（如可行）
D. 以上所有选项均错误
【多选题】
中国CML诊疗指南推荐，CML-AP患者可接受（ ）治疗。
A. 伊马替尼600 mg QD
B. 干细胞移植（如可行）
C. 临床试验（如可行）
D. 以上所有选项
【多选题】
作为（ ）酪氨酸激酶抑制剂，格列卫彻底改变了CML的治疗。
A. 第一个
B. 第二个
C. 第三个
D. 第四个
【多选题】
( )可对BCR-ABL转录本进行定量分析，所以是Ph+ CML治疗反应深度监测中灵敏度最高的监测手段。
A. 全血细胞计数
B. FISH
C. RT-Q-PCR
D. 突变分析
【多选题】
2013年ELN指南推荐，CML-AP/BC患者一线接受（）治疗。
A. TKI
B. 干扰素
C. 羟基脲
D. 化疗
【多选题】
2013年ELN指南推荐，伊马替尼不耐受CML-CP患者可接受（）治疗。
A. 达沙替尼
B. 尼洛替尼
C. 伊马替尼加量
D. 选项1和2
【多选题】
2013年ELN指南推荐，伊马替尼治疗疗效欠佳的CML-CP患者可接受（）治疗。
A. 维持相同剂量伊马替尼治疗
B. 伊马替尼加量
C. 达沙替尼或尼洛替尼
D. 以上所有选项
【多选题】
2013年ELN指南推荐，伊马替尼治疗失败的CML-CP患者可接受（）治疗。
A. 达沙替尼
B. 尼洛替尼
C. alloHSCT
D. 以上所有选项
【多选题】
2013中国CML指南中推荐分子学反应的监测频率为？
A. 每周进行一次，直至确认达到稳定MMR，随后每3个月进行一次
B. 每3个月进行一次，直到获得稳定MMR，随后应每3-6个月检测一次
C. 每3-6个月进行一次，直到获得稳定MMR，随后应每3-6个月检测一次
D. 以上所有选项
【多选题】
AP和BC分别是指（）。
A. 慢性期和加速器
B. 加速期和急变期
C. 慢性期和急变期
D. 加速期和慢性期
【多选题】
CML预后分析Sokal积分公式中包含（）等预后因素。
A. 年龄、脾脏大小、血小板、原始细胞
B. 年龄、脾脏大小、血小板、嗜酸性细胞百分数
C. 年龄、脾脏大小、血小板、嗜碱性细胞百分数
D. 以上所有选项均错误
