【单选题】
( ) 27. What does the prince do after the fox tells him a secret?
A．He cares more about a flower and a sheep．
B．He meets many more strange adults on other planets．
C．He realizes his love for the rose and he goes back to his planet．
D．He discovers interesting things such as a snake, other roses and a fox
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【单选题】
( ) 28. What does "The little Prince" mainly talk about? It' s about _________．
A．the adult world B．the planet B -612
C．a rose and a fox D．the adventure of a young prince
【单选题】
( ) 29. What is the writer's main purpose（目的）in writing this passage？
A．To tell the readers his life story．
B．To tell people what kind of person his father was．
C．To tell the readers what present he got from his father．
D． To let people know how poor he was．
【单选题】
( ) 30. Why did the father not ask his son not to do this and do that？
A．Because he felt quite confident of his son．
B．Because he was born from a poor family．
C．Because he was a man of few words．
D．Because he didn't want to be much too strict with his son．
【单选题】
( ) 31. What would someone learn from this passage？
A．How to live by oneself． B．How to stand on one's own feet．
C．What a good father should do． D．What the self-important is like．
【单选题】
( ) 32. What may be the proper Chinese for the underlined part in the passage？
A．闲暇时光 B．学费 C．精神空虚 D．经济不足
【单选题】
( ) 33. Why did Natalie Smith pay for the six cars behind her?
A. She had seven tickets.
B. She hoped to please others.
C. She knew the car drivers well.
D. She wanted to show kindness.
【单选题】
( ) 34. Judy Foreman copied down the phrase because she ___ .
A. thought it was beautifully written
B. wanted to know what it really meant
C. decided to write it on a warehouse wall
D. wanted her husband to put it up in the classroom
【单选题】
( ) 35. Who came up with the phrase according to the passage?
A. Judy Foreman. B. Natalie Smith. C. Anne Herbert D. Alice Johnson.
【单选题】
( ) 36. What can we infer from the last paragraph?
A. People should practice random kindness to those in need.
B. People who receive kindness are likely to offer it to others.
C. People should practice random kindness to strangers they meet.
D. People who receive kindness are likely to pay it back to the giver.
【单选题】
( ) 37.The greatest river for navigation is ___________.
A. the Nile B. the Amazon C. the Mekong D. the Mississippi
【单选题】
( ) 38. From a dam, people can use the water for ___________.
A. keeping the rivers clean B. only making electricity
C. irrigation and making electricity D. washing clothes
【单选题】
( ) 39. The water in the river is polluted because of _____________.
A. people's drinking water too much B. people's swimming in the river too much
C. chemicals and other materials D. people's building a dam across a river
【单选题】
( ) 40. The best title of the passage is ___________.
A. Rivers in Cities B. The importance of Rivers
C. Transportation D. Natural Resources
【单选题】
) 1. Even Tony’s six-year-old son asked him ______ smoking.
A. stops B. stopped C. to stop D. stopping
【单选题】
2.—What do you think of the lecture of Li Yang’s Crazy English?
— I think it’s _______ , but someone thinks it’s much too ________.
A. wonderful enough; bored B. enough wonderful; boring
C. enough wonderful; bored D. wonderful enough; boring
【单选题】
3.—He didn’t go to the lecture this morning, did he?
— _____ ．Though he was not feeling very well．
A. No, he didnt B. Yes; he did C. No, he did D. Yes, he didnt
【单选题】
4. If you read a lot, your life ______ full of pleasure.
A. will be B. is C. be D. was
【单选题】
5. The black bag _________ be Annas. She has a blue one.
A. should B. cant C. wouldnt D. could
【单选题】
6. Susan, why are you still here? They are all ready to start.
Im sorry, but I _________ when to start.
A. dont tell B. wasnt told C. didnt tell D. havent told
【单选题】
7.—Why dont you choose the red tie?
—For me, it doesn’t _____ my shirt very well．
A. fix B. accept C. compare D. match
【单选题】
8. — Could you tell me ______? I must find him．
— Sorry．I don’t know．But he was here just now．
A. where Tom was B. where Tom is
C. where has Tom gone D. where can I find Tom
【单选题】
9. —What did Mr Green say to you?
— What a heavy rain! How did you come here? He asked________.
A. at all B. in fact C. in surprise D. as a result
【单选题】
10. I often see Tom on the playground．When I passed the playground yesterday, I saw him ．
A. play; playing B. to play; play C. playing; to play D. playing; play
【单选题】
11. — Mum, could I have ____________ to drink?
— Oh, dear．You can only drink some water．There is _________ in the kitchen．
A. anything; else something B. anything; something else
C. something; else nothing D. something; nothing else
【单选题】
12. We all know that learning a foreign language _______ time and effort.
A. requires B. reduces C. removes D. repeats
【单选题】
13. Her son __________ Coke, but now he __________ milk．
A. is used to drinking; used to drink B. used to drink; uses to drink
C. used to drink; is used to drinking D. is used to drink; is drinking
【单选题】
14. I don’t know the teacher is talking with Miss Wang．
A. what B. whom C. who D. which
【单选题】
15.Millie does __________ that many people are thankful to her．
A. such an important and helpful job B. so important and helpful work
C. a very important and helpful job D. such an important and helpful work
【单选题】
16. I think eating more vegetables is good _______ our health.
—Yes, I agree _______ you.
A. at, to B. for, with C. to, to D. for, to
【单选题】
17. I often go on holiday with my parents _____ summer.
A. in B. at C. on D. of
【单选题】
18. I called you at 4:00 yesterday afternoon, but nobody answered.
Sorry, I ______ with my friends at that time.
A. had swum B. swam C. would swim D. was swimming
【单选题】
19.––Who is on the playground? ---__________．
A. Never B. None C. No one D. A lot
【单选题】
20. The schoolboy ______ a blind man cross the street yesterday.
A. helps B. helped C. will help D. has helped
【单选题】
21. —The 2010 World Expo which will last 184 days will be held in Shanghai on May 1st.
—________exciting news! We shall try our best to support it.
A. How B. How an C. What D. What an
【单选题】
22. They preferred ______ in bed rather than _____ horses．
A. to lie; to ride B. lying; riding C. lying; ride D. to lie; ride
【单选题】
23. —What was Jim wearing at the party?
— Nothing _______. He was in his usual shirt and jeans.
A. special B. simple C. important D. interesting
【单选题】
24. The 2016 Olympic Games ________ in Brazil. Would you like to go there?
Maybe, if possible.
A. are held B. will be held C. were held D. have been held
【单选题】
25. — David, look at the man in white over there．Can you tell me _______ ?
—He is a doctor．
A. who is he B. who he is C．what does he do D. what he does
【单选题】
( ) 26.With help from a Mr. H, you can__________.
A. stop wearing your watch B. get new books and objects
C. finish your homework on time D. know when parents or teachers are near
【单选题】
( ) 27. A PENGO WATCH CONTROL can help you to ______________.
A. repair your TV B. put away your books and objects
C. become a James Bond D. get a daily weather report
推荐试题
【多选题】
ENESTop研究中，在符合严格的TFR尝试资格标准的患者中，停药144周后仍可保持TFR(无MMR丢失或MR4确认丢失)的患者比例为
A. 0.189
B. 0.237
C. 0.376
D. 0.484
【多选题】
ENESTop研究中MMR丢失或MR4确认丢失后重新启动后，每月监测一次，直到以前的MMR或MR4重新建立，此后监测时间为
A. 每4周一次
B. 每6周一次
C. 每12周一次
D. 每半年一次
【多选题】
ENESTswift 研究中大约三分之一的患者在因对伊马替尼或达沙替尼耐受不良而改用达希纳3个月后达到
A. 无MMR
B. MMR
C. MR4
D. MR4.5
【多选题】
ENESTxtnd研究中，一线达希纳300mg BID治疗反应欠佳或治疗失败后患者允许增加剂量至
A. 350 mg BID
B. 400 mg BID
C. 450 mg BID
D. 500 mg BID
【多选题】
ENESTxtnd研究中，一线达希纳治疗反应欠佳或治疗失败后增加剂量治疗后患者24个月内达到MMR的比例超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4的患者比例为
A. 0.54
B. 0.64
C. 0.73
D. 0.88
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者，（ ） 患者回复至慢性期。删除
A. 0.7
B. 0.85
C. 0.9
D. 0.96
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者，CHR持续率和CCyR持续率率可达（ ） 。
A. 0.56
B. 0.81
C. 56%和81%
D. 81%和56%
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者的7年OS达（ ）。
A. 0.43
B. 0.3
C. 0.23
D. 0.17
【多选题】
ICH是指（ ）。
A. 欧洲药品管理局
B. 国际协调会议
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
ICH指南推荐：如果药物有不同的晶型，应选择（ ） 的晶型。
A. 最多
B. 最常见
C. 热力学最稳定
D. 最易获得
【多选题】
IRIS研究中，伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
"PCR检测BCR-ABL mRNA转录，是灵敏度最高的检测方法，能在（ ） 细胞中检测出1个异常细胞。
A. 1000个
B. 1万个
C. 10万个
D. 100万个
【多选题】
Ph+CML的治疗和监测的发展主要是基于其特征性基因缺陷: （ ）。
A. Src
B. BCR-ABL
C. PDGFR
D. KIT
【多选题】
Ph+CML慢性期患者因换用α晶型仿制品而导致的生存期下降模型显示，格列卫换用α晶型仿制品治疗最差的情况下，患者质量调整生存年仅有（ ） 。
A. 13.44年
B. 1.8年
C. 9.57年
D. 5年
【多选题】
Ph+CML治疗中非常重要，是多数停药试验入组的必要条件。
A. 血液学反应
B. 细胞遗传学反应
C. 分子学反应
D. 更深的分子学反应（MR4.5）
【多选题】
RT-PCR能够在（ ）。
A. 20到25个细胞中检出1个白血病细胞
B. 200到500个细胞中检出1个白血病细胞
C. 2000到5000个细胞中检出1个白血病细胞
D. 10万到100万个细胞中检出1个白血病细胞
【多选题】
RT-Q-PCR非标准化是（ ）造成的。
A. 由于方法学和报告不同，导致结果各异
B. 每个患者的结果伴随一定程度的时间波动
C. 实验室间的结果比较不可行
D. 以上所有选项
【多选题】
Sokal评分是CML预后评估的一种方式，Sokal评分（ ）是高危患者？
A. Sokal评分<0.8
B. Sokal评分在0.8~1.2之间
C. Sokal评分>1.2
D. 以上均不正确
【多选题】
X-射线粉末衍射所示—α晶型和β晶型（ ）。
A. 存在差异
B. 不存在差异
C. 没有差异
D. 以上所有选项均错误
【多选题】
α晶型仿制品不仅稳定性差，还普遍存在（ ） 含量超标。
A. 遗传学毒性杂质
B. 活性成分
C. 选项1和2
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼（ ） 格列卫。
A. 就是
B. 不等于
C. 优于
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼处于（ ） ，可能向β晶型转变。
A. 高能态
B. 低能态
C. 稳定态
D. 以上所有选项均错误
【多选题】
α晶型结构不稳定，可向β晶型自发转换，其可导致药物肉眼可见的改变，如（ ）。
A. 药片崩裂
B. 药液变色
C. 药液变浑浊
D. 以上所有选项
【多选题】
α晶型吸水性强，吸水溶解游离出甲磺酸阴离子与结晶时残留的乙醇反应生成（ ）。
A. 甲磺酸甲酯
B. 甲磺酸乙酯
C. 选项1和2
D. 以上所有选项均错误
【多选题】
β晶型的吸水性明显比α晶型（ ） ，吸水性强可影响药物的稳定性。
A. 更低
B. 更高
C. 相同
D. 以上所有选项均错误
【多选题】
不同国家和地区仿制品的注册标准（ ） ，如进行人体生物利用度和生物等效性试验，成分鉴定和杂质定性评价和严格遵守cGMP规定。
A. 基本相同
B. 存在很大差异
C. 存在较小差异
D. 以上所有选项均错误
【多选题】
除颜色、形态/多晶型和熔点外，受多晶型影响的特征有（ ）。
A. "溶解度和生物利用度
B. "吸水性和晶体硬度，密度
C. "多态形式之间的转变和化学稳定性
D. 以上所有选项
【多选题】
达到哪项治疗反应代表具备TFR可能
A. CHR
B. CCyR
C. MR4.5
D. MMR
【多选题】
达希纳（ ）包装已于2013年在中国上市？
A. 150 mg
B. 100 mg
C. 200 mg
D. 250 mg
【多选题】
达希纳不良反应皮疹的推荐处理方案为 （ ）。
A. 精神兴奋药、运动和静养休息
B. 对乙酰氨基酚和非甾体类抗炎药
C. 抗酸药、质子泵抑制剂、止吐药
D. 局部或全身抗组胺药、局部或全身皮质类固醇治疗
【多选题】
达希纳的适应症为（ ）?
A. 既往治疗（包括伊马替尼）耐药Ph+CML慢性期或加速期成人患者
B. 既往治疗（包括伊马替尼）不耐受Ph+CML慢性期或加速期成人患者
C. 以上均正确
D. 以上均不正确
【多选题】
达希纳服药（ ）小时后，药物达到峰浓度。
【多选题】
达希纳服药前（ ）小时之内和服药后（ ）小时之内避免进食。
A. 2，1
B. 1，2
C. 1，1
D. 2，2
【多选题】
达希纳禁用于（ ）患者?
A. 对达希纳活性物质或任何赋形剂成分过敏者
B. "伴有低钾血症、
C. 长QT综合症的患者
D. 以上均正确
【多选题】
达希纳精准强效抑制BCR-ABL，其靶向作用于酪氨酸激酶的先后顺序是（ ）。
A. Src > Bcr-Abl > PDGFR > c-KIT
B. PDGFR > c-KIT > Bcr-Abl
C. Bcr-Abl > PDGFR > c-KIT
D. 以上所有选项均错误
【多选题】
达希纳俗称“第二代格列卫”，于（ ）年在中国上市。
A. 2009年
B. 2010年
C. 2011年
D. 2012年
【多选题】
达希纳推荐剂量为（ ）。
A. 400mg BID
B. 400mg QD
C. 200mg BID
D. 200mg QD
