【单选题】
- Do you think I can borrow your bike for a few hours?____
A. I'm afraid you can.
B. I'm sorry, but I really need it this afternoon.
C. Yes, I don't think so.
D. I'll think about it later.
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相关试题
【单选题】
- Thank you very much for the dictionary you sent me.____
A. No thanks.
B. I'm glad you like it.
C. Please don't say so.
D. No, it's not so good.
【单选题】
- How do you like the movie we saw yesterday?____
A. You are welcome.
B. How about you?
C. I've never seen a better movie than it.
D. It is very expensive.
【单选题】
- What do you think of your new teacher____
A. He came to teach us last week.
B. He teaches us English.
C. He has two children.
D. He is very nice.
【单选题】
- Are you going to have a holiday?____
A. Not until next week.
B. Three weeks ago.
C. To Beijing.
D. I'm pleased to hear that.
【单选题】
- You seem to be lost. Need help? ____
A. Yes, would you please help me with the bag?
B. Help me find my key, please.
C. Yes, with pleasure.
D. I'm looking for Zhongshan Road.
【单选题】
- Can you help me clear up the mess____
A. Yes, it doesn't matter.
B. No, that's OK.
C. Yes, help yourself.
D. No problem.
【单选题】
- Does No.20 bus stop at our school?____
A. I go to school by bus.
B. I'm afraid not.
C. You are welcome.
D. I'll not take No.20 bus.
【单选题】
- Can I help you? ____
A. Sorry, I don't need your help.
B. What help can you give us?
C. I'd like to try on these shoes, please.
D. Thanks. You are welcome.
【单选题】
- Sorry to have kept you waiting. ____
A. That's OK.
B. What are you doing?
C. What's wrong with you?
D. Where have you been?
【单选题】
- What is she?____
A. She is a typist.
B. She is talking to her friend.
C. She is having a holiday.
D. She is my sister.
【单选题】
- That's a beautiful cat. I wonder who it belongs to.____
A. It belongs to the
B. rowns. B.The cat is my favourite too.
C. Mind your own business.
D. I can't say anything more.
【单选题】
- Excuse me, could you tell me the time____
A. You'd better buy a watch.
B. It's three thirty by my watch.
C. Can you see the clock?
D. It's late I think.
【单选题】
- What do you think of the movie we saw last night?____
A. The actress is bad.
B. Terrific!
C. The theatre is bad.
D. Nobody was there.
【单选题】
___ No, thanks. I'm just looking around. I'll let you know if I want anything.
A. Could you help me?
B. What will you buy?
C. Can I help you?
D. Do you like to look around?
【单选题】
- Hello, Peter. What do you do?____
A. I am fine.
B. I am not sick.
C. I am a student from Bonn University.
D. I came from Bonn University.
【单选题】
-Excuse me; can I have a seat here?___
A. Be hurry.
B. Come on.
C. Yes, please.
D. Do you mind?
【单选题】
- Shall we sit up here on the grass or down there near the water?___
A. I'd rather stay here if you don't mind.
B. Sorry, I don't like neither.
C. Certainly, why not？
D. Yes, we like these two places.
【单选题】
- What do you do on Sunday?___
A. I 'm a teacher.
B. I play football.
C. You are a student.
D. They clean rooms.
【单选题】
- Our class won the girls' relay race in our school's sports meeting.___
A. That's right.
B. Thanks a lot.
C. Congratulations!
D. It's a pleasure.
【单选题】
- Hi, is Mary there, please?___
A. Hold on. I'll get her.
B. No, she isn't here.
C. Yes, she lives here.
D. Yes, what do you want?
【单选题】
- I am afraid I can't return the book to you before Friday. ___
A. Don't be afraid
B. Be careful
C. Not at all
D. Take your time
【单选题】
- I really don't know how to thank you enough. ___.
A. No problem
B. Think nothing of it
C. Not at all
D. It doesn't matter
【单选题】
- Must I be home before seven? ___.
A. No, you needn't
B. No, you mustn't
C. Yes, you will
D. No, you won't
【单选题】
-I'm sorry to hear that you failed in the exam______.
A. Not at all
B. Oh, thank you.That's very kind of you
C. You are welcome
D. Yes, I'm really sorry
【单选题】
-I will,______.
A. that's all right
B. thank you
C. all right
D. not at all
【单选题】
-Hello, may I speak to Zhao Hua?_____.
A. My name is Zhao Hua
B. I'm Zhao Hua
C. This is Zhao Hua speaking
D. Zhao Hua is me
【单选题】
___This is Mr Smith speaking now.
A. Who are you
B. Who is that
C. Who are you calling
D. What do you want to say
【单选题】
- I was worried about my maths, but Mr. Brown gave me an A.___
A. Don't worry about it.
B. Congratulations! That's a difficult course.
C. Mr. Brown is very good.
D. Good luck to you！
【单选题】
-Would you go to the concert with me?___, but I'm very busy now.
A. I'd like to
B. Sure
C. No problem
D. Certainly
【单选题】
-I'll be away on a business trip. Would you mind looking at my cat?Not at all. _______.
A. I have no time
B. I'd rather not
C. You can leave
D. I'd be happy to
【单选题】
- Hi, Jim! Nice to meet you.____.
A. Certainly
B. Many thanks
C. OK
D. Nice to meet you, too
【单选题】
- Hello, may I speak to Mike?_____
A. Who are you?
B. Sorry, he isn't in.
C. Thank you very much.
D. Yes, here you are.
【单选题】
- Will you join us for lunch?____.
A. No, I won't
B. Yes, with pleasure
C. Yes, please
D. Yes, help yourself
【单选题】
- Thank you for your great dinner. I really enjoyed it._____you enjoyed it.
A. I'm so glad
B. I'm sorry
C. What a pity
D. Surprisingly
【单选题】
- I heard Susan surprised her teacher by working hard. Yes, ___
A. her teacher worked hard.
B. Susan worked hard.
C. the teacher was surprising.
D. Susan was surprised.
【单选题】
- Peter, don't step on the grass_______.
A. It doesn't matter
B. I can't do it
C. Don't worry
D. Sorry, I won't do it again
【单选题】
- How was your journey to Paris? - ____
A. It went very well.
B. I flew there.
C. I love Paris.
D. Thank you for asking.
【单选题】
- I'm sorry for being late, Mr Lt______.
A. All right
B. That's right
C. Not at all
D. Never mind
【单选题】
- Happy birthday to you! ___!
A. Happy birthday to you
B. I'm very glad
C. That's all right
D. Thank you
【单选题】
- Do you like country music?___.
A. Yes, I like basketball a lot
B. It's far too crowded
C. Yes, I'm crazy about it
D. Oh, it's funny
推荐试题
【多选题】
根据ELN指南，达到满意疗效的Bcr-Abl转录本的水平是（ ）。
A. TKI 治疗3个月，Bcr-Abl ： ≤ 10%
B. TKI 治疗6个月，Bcr-Abl ： ≤ 1%
C. TKI 治疗12个月，Bcr-Abl ：≤0.1%
D. 所有选项均不正确
【多选题】
服用达希纳时，应注意的事项有（ ）。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
服用达希纳时，如果出现有显著临床意义的中度或严重的非血液学毒性，应该暂停服药。
【多选题】
服用达希纳时，任何时候都应该避免进食（ ）。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
达希纳能够抑制（ ）激酶的自磷酸化。
A. Bcr-Abl（20-60nM）
B. PDGFR（69nM）
C. Src
D. c-Kit（210nM）
【多选题】
达希纳胶囊服用时，可以咀嚼或吮吸，可以打开胶囊。
【多选题】
达希纳含有乳糖，所以对于（ ）的患者，不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳服用时，如果错过给药，患者不得另外补充剂量，而是按照处方服用下一次剂量。
【多选题】
伴有（ ）的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
TKI治疗均的CV风险管理中，属于可更改的因素有（ ）。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
【多选题】
TKI治疗均的CV风险管理中，属于不可更改的因素有（ ）。
【多选题】
ENESTnd研究中的分组有（ ）。
A. 达希纳300mg BID
B. 达希纳400mg BID
C. 伊马替尼400mg QD
D. 伊马替尼400mg BID
【多选题】
ENESTnd研究中，在5年随访中，所有时间点达希纳组MMR的比例始终高于伊马替尼组。
【多选题】
ENESTnd研究中，与伊马替尼相比，达希纳一线治疗组疾病进展至AP/BC显著更少。
【多选题】
ENESTnd研究中，排除（ ）类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
ENESTnd研究中，从第一年至第五年的随访中，达希纳和伊马替尼组累积的MR4.5相差的比例保持完全不变。
【多选题】
ENESTnd标志性分析中，3个月时获得BCR-ABLIS≤10%与60个月时更佳的OS无关
【多选题】
在TIDEL-II研究中，服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在ENESTnd研究中，在伊马替尼400mg每天治疗失败后将剂量增加至600或800 mg每天不会导致超过一半的患者反应改善。
【多选题】
在ENESTnd研究所有风险组中，伊马替尼治疗的EMR失败率比达希纳高3-4倍。
【多选题】
在ENESTnd或DASISION研究中，5年随访时，伊马替尼二线治疗组获得MR4.5的中位时间均未达到。
【多选题】
"与竞品达沙替尼相比，达希纳精准强效抑制BCR-ABL
【多选题】
与竞品达沙替尼相比，达希纳非血液学不良反应交叉不耐受发生率高？
【多选题】
以下关于DASISION研究的描述，正确的是（ ）。
A. DASISION试验的研究终点是CCyR，而不是MMR
B. DASISION试验中，达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中，达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
IRIS研究中，伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
IRIS研究随访10年, 32% 伊马替尼治疗患者由于不满意治疗反应中断治疗，＞10%由于不良事件。
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENESTnd研究中在伊马替尼治疗12个月内的MMR率为27%。
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
DASISON 研究中，达沙替尼胸腔积液的复发率是（ ）。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
DASISION研究的终点是（ ）。
A. 6个月内，证实获得的CCyR
B. 12个月内，证实获得的CCyR
C. 6个月内，证实获得的MMR
D. 12个月内，证实获得的MMR
【多选题】
DASISION 研究4年随访中，22%的达沙替尼治疗患者中经常报告的不良事件是（）。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
ENESTFreedom研究中，重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
在研究2101中，换用达希纳400 mg BID后大多数获得反应的患者达到 Ph+ < 35%的时间为
A. 1个月内
B. 3个月内
C. 6个月内
D. 12个月内
【多选题】
在格列卫治疗出现的33种突变中，达希纳能够有效抑制其中种突变？
A. 15种突变
B. 20种突变
C. 32种突变
D. 33种突变
【多选题】
在服用达希纳最初的2个月，由于骨髓抑制，应每隔（ ）做一次全血细胞计数，之后可每（ ）检测一次，或者在有临床指征时进行。
A. 2周，1个月
B. 1周，2个月
C. 3周，1个月
D. 2周，2个月
【多选题】
在服药前至少4小时以及服药后至少4小时内不能进食？
