【多选题】
TKI治疗均的CV风险管理中，属于可更改的因素有（ ）。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
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相关试题
【多选题】
伴有（ ）的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
达希纳含有乳糖，所以对于（ ）的患者，不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳能够抑制（ ）激酶的自磷酸化。
A. Bcr-Abl（20-60nM）
B. PDGFR（69nM）
C. Src
D. c-Kit（210nM）
【多选题】
达希纳说明书对伊马替尼不耐受的定义是（ ）：
A. 尽管采用了最佳支持治疗，在任何剂量和/或治疗期间，患者仍由3或4级不良事件的持续存在而中止伊马替尼治疗。
B. 尽管采用了最佳的支持治疗，与伊马替尼治疗相关的2级不良事件仍持续时间≥1个月，或反复发生超过3次，不论是否剂量减少或中止治疗。
C. 尽管采用了最佳支持治疗，在任何剂量和/或治疗期间，患者仍由1或2级不良事件的持续存在而中止伊马替尼治疗。
D. 尽管采用了最佳的支持治疗，与伊马替尼治疗相关的2级不良事件仍持续时间≥3个月，或反复发生超过3次，不论是否剂量减少或中止治疗。
【多选题】
对伊马替尼治疗中女性CML患者计划妊娠并生产后的管理描述正确的是：（ ） 。删除
A. 若处于CMR或MMR，不予治疗
B. 若丧失CMR或MMR，考虑治疗
C. 若丧失CHR，需予以治疗
D. 以上所有选项均错误
【多选题】
对伊马替尼治疗中意外妊娠的女性患者的推荐处理描述正确的是：（ ） 。
A. 立即中断服用伊马替尼，以避免或减少药物潜在的致畸毒性
B. 孕3个月以上者继续服药并继续妊娠，同时严密监测胎儿发育情况，一旦发现可识别的显著异常则终止妊娠
C. 尽管已有不少发现怀孕后仍持续服用伊马替尼并产出正常婴儿的案例，但需警惕的是，母亲在妊娠的前三个月内接触伊马替尼对胎儿致畸的风险较大
D. 以上所有选项均错误
【多选题】
对于达希纳停药研究的描述，下列哪项正确
A. 丧失MMR的患者重启原剂量达希纳治疗后仍能很快重新获得分子学反应
B. 持续随访将继续评估尼达希纳长期停药后的持续缓解情况
C. 停药应在严格管理的TFR研究中进行
D. 以上均不正确
【多选题】
服用达希纳时，任何时候都应该避免进食（ ）。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
服用达希纳时，应注意的事项有（ ）。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
符合（ ）其中任何一项，即可判断为CML加速期。
A. 外周血或骨髓中原始细胞占0.10-0.19
B. 外周血嗜碱粒细胞≥0.20
C. 与治疗无关的持续血小板减少或白细胞计数增高
D. 克隆演变
【多选题】
符合（ ）其中任何一项，即可诊断为CML急变期。
A. 外周血或骨髓中原始细胞≥0.20
B. 骨髓活检原始细胞聚集
C. 髓外原始细胞浸润
D. 所有选项均不正确
【多选题】
根据ELN指南，达到满意疗效的Bcr-Abl转录本的水平是（ ）。
A. TKI 治疗3个月，Bcr-Abl ： ≤ 10%
B. TKI 治疗6个月，Bcr-Abl ： ≤ 1%
C. TKI 治疗12个月，Bcr-Abl ：≤0.1%
D. 所有选项均不正确
【多选题】
根据NCCN指南V4.2018，换用其他TKI药物治疗的指征包括
A. 随访3个月，BCR-ABLIS > 10%
B. 随访6个月，BCR-ABLIS > 10%
C. 随访12个月BCR-ABLIS 1%-10%
D. 随访＞12个月BCR-ABLIS > 1%
【多选题】
根据中国CML指南2016年版，CML慢性期标准为（ ）。
A. 外周血或骨髓中原始细胞＜0.10
B. 外周血或骨髓中原始细胞≥0.20
C. 髓外原始细胞浸润
D. 未达到诊断加速期或急变期的标准
【多选题】
关于ENESTnd和ENESTchina 研究, 以下说法正确有（ ）。
A. ENESTnd是3臂试验，ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTnd中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
接受伊马替尼治疗的生产后的女性患者，（ ）。
A. 母乳中无伊马替尼代谢物
B. 母乳中存在伊马替尼代谢物
C. 可哺乳
D. 避免哺乳
【多选题】
目前移植存在的问题是（ ） 。
A. 移植后患者生存率逐年下降
B. 复发率逐年上升
C. 死亡率逐年上升
D. 以上所有选项均错误
【多选题】
哪些属于非血液学不良反应（ ）。
A. 中性粒细胞减少症
B. 胃肠道异常
C. 皮疹
D. 肌痛
【多选题】
哪些属于血液学不良反应（ ）。
A. 血小板减少症
B. 中性粒细胞减少症
C. 腹泻
D. 贫血
【多选题】
评价二代TKI做为新诊断CML-CP患者一线治疗疗效和安全性研究的临床试验包括（ ）。
A. ENESTnd
B. ENESTchina
C. DASISION
D. ENESTcmr
【多选题】
如果出现血液学毒性( )，应暂停达希纳的使用。
A. 加速期：ANC<0.5×109/升或血小板<10×109/升
B. 慢性期：ANC<1.0×109/升或血小板<50×109/升)
C. 加速期：ANC<1×109/升或血小板<10×109/升
D. 慢性期：ANC<10×109/升或血小板<50×109/升
【多选题】
如果临床需要，达希纳可与造血生长因子或其他联用，例如（ ）。
A. EPO
B. G-CSF
C. 羟基脲
D. 阿那格雷
【多选题】
使用Sokal风险评分将Ph+ CML患者分层为高度风险，中度风险和低度风险类别，其基于具有预后意义的独立因子包括
A. 患者
B. 脾肿大程度
C. 血小板计数
D. 外周原始细胞百分比
【多选题】
属于CYP3A4诱导剂的是（ ）。
A. 利福平
B. 卡马西平
C. 苯巴比妥
D. 贯叶连翘
【多选题】
下列哪项是ENESTFreedom研究TFR期的PCR检测频率
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
下列哪项是达到MR4.5的意义
A. 无疾病进展风险
B. 远期生存延长
C. 具备TFR可能
D. 以上都不是
【多选题】
下列哪项是达希纳停药研究TFR期可能出现的不良事件
A. 骨骼肌肉痛
B. 体液潴留
C. 皮疹
D. 心血管事件
【多选题】
下列哪项是达希纳停药研究巩固期可能出现的不良事件
A. 骨骼肌肉痛
B. 胰腺炎
C. 皮疹
D. 心血管事件
【多选题】
相比格列卫，达希纳一线治疗的哪项优势与TFR相关
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 以上均不正确
【多选题】
以下（ ）情况需要慎用达希纳。
A. 长QT综合征
B. 肝损害，电解质紊乱
C. 胰腺炎，严重的糖尿病
D. 所有选项均不正确
【多选题】
以下达希纳主信息包括（ ）。
A. 达希纳是专为CML设计的二代TKI，强效精准抑制BCR-ABL
B. 达希纳更快获得更深缓解，减少疾病进展
C. 达希纳耐受性好，不良反应可预测，易管理
D. 达希纳有150mg，200mg2种剂型，方便患者使用
【多选题】
以下关于DASISION研究的描述，正确的是（ ）。
A. DASISION试验的研究终点是CCyR，而不是MMR
B. DASISION试验中，达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中，达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
以下哪个说法是正确的是（ ）。
A. 所有TKI由于抑制野生型Bcr-Abl，都会对心血管系统产生影响
B. 临床试验证实：达希纳治疗患者的心血管事件发生率与同年龄组普通人群相似
C. 所有进行TKI治疗的CML患者，都应该进行心血管风险因素的评估
D. 所有选项均不正确
【多选题】
以下英文缩写与中文正确对应的是（ ）
A. PCyR：部分细胞遗传学反应
B. CCyR：完全细胞遗传学反应
C. MMR：主要分子学反应
D. 所有选项均不正确
【多选题】
由于药物相互作用，服用达希纳时，应该避与（ ）同时使用。
A. 酮康唑
B. 伊曲康唑
C. 伏立康唑
D. 克拉霉素
【多选题】
有研究推荐，晚期CML患者移植后为预防急性移植物抗宿主病（aGVHD），可接受（ ） 治疗。删除
A. 环孢素A
B. 霉酚酸酯
C. 短期甲氨蝶呤
D. 以上所有选项均错误
【多选题】
与伊马替尼相比，达希纳作为一线治疗的优势是（ ）。
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 所有选项均不正确
【多选题】
在ENESTnd研究随访6年时，CML患者死亡最常见的原因为
A. 晚期CML
B. 疾病进展
C. 肺炎
D. 心血管事件
【多选题】
"在ENESTnd研究中接受伊马替尼核心治疗反应欠佳/治疗失败的患者换用达希纳400 mg BID后患者达到CCyR和MMR的比例分别为
A. 0.58
B. 0.6
C. 0.32
D. 0.42
推荐试题
【单选题】
The networking team has requested to have a dedicated network for iSCSI traffic. This task has been assigned to the vSphere Administrator. What is the VMware-recommended way to accomplish this?___
A. Configure Static Routes on each ESXi Server.
B. Configure the right subnet.
C. Create a custom IP Stack.
D. Define a dedicated gateway for the iSCSI vmkernel.
【单选题】
To prevent possible failures or issues during a vSphere upgrade, which component should be upgraded first?___
A. ESXi Hosts
B. virtual machines
C. datastores
D. vCenter Server
【单选题】
What is the command for updating an ESXi host?___
A. esxcli software vib update –d /vmfs/volumes/Datastore/DirectoryName/PatchName.zip
B. esxupdate software update –d”/vmfs/volumes/Datastore/DirectoryName/PatchName.zip”
C. esxcli software update –d “/vmfs/volumes/Datastore/DirectoryName/PatchName.zip”
D. esxupdate software vib update –d /vmfs/volumes/Datastore/DirectoryName/PatchName.zip
【单选题】
A vSphere Administrator would like to identify which physical NUMA node their virtual machine is currently residing on. What esxtop metric would provide this information?___
A. GST_ND[x]
B. OVD_ND[x]
C. NRMEM
D. NHN
【单选题】
How can a vSphere administrator ensure that two virtual machines never run on the same datastore in a datastore cluster, while permitting the VMs to be load-balanced?___
A. Use an Intra-VM Anti-Affinity Rule.
B. Configure a storage DRS VM override.
C. Disable storage
D. RS for the VMs.
【单选题】
What is the VMware-recommended way to move a physical adapter out of Network I/O Control’s scope?___
A. Set the teaming policy to “Route Based on Physical NIC Load.”
B. Add the vmnic to the Net.NetNiocAllowOverCommit parameter in Advanced System Settings.
C. Add the vmnic to the Net.IOControlPnicOptOut parameter in Advanced System Settings.
D. Move the vmnic to a different vmUplink port on the Distributed Switch.
【单选题】
A VM folder contains VM1 and VM2. Group A has permission to power on virtual machines, defined on the VM folder and its children. Group B has permission to power off virtual machines, defined on the VM folder and its children. If a user is a member of Groups A and B, what will be the user’s effective permission on VM1 and VM2?___
A. Power on
B. Power off.
C. Power on and Power off.
D. Reset.
【单选题】
Group 1 is granted console interaction on a VM folder. User 1 is granted no console interaction on the same VM folder. What will be the outcome if User 1 tries to access the console of a virtual machine?___
A. User 1 will not be able to access the virtual machines in the VM folder.
B. User 1 will not have access to the virtual machine console.
C. User 1 will have access to the virtual machine console.
D. User 1 will have console access only via the vSphere Web Client.
【单选题】
Which statement is true regarding the use of VMFS3 datastores with vSphere 6.5?___
A. VMFS3 datastores can be used but not created.
B. VMFS3 datastores can be neither used nor created.
C. VMFS3 datastores will be present but unmounted.
D. VMFS3 datastores can be created and used.
【单选题】
In the Exhibit, each VM has a 1GHz non-expandable reservation. If all VMs are powered on in sequence, what would be the outcome?___
A. VM4 cannot be powered on.
B. VM5 cannot be powered on.
C. VM6 cannot be powered on.
D. VM3 cannot be powered on.
【单选题】
vSphere 6.5 introduced MAClearning capabilities for VMware’s virtual switches. What three benefits will it provide? (Choose three.)___
A. Reduced memory consumption.
B. Reduced consumption of extra CPU cycles.
C. Increased network throughput.
D. Prevent packet flooding inside the vSwitch.
【单选题】
What is the default pathing policy for most active-active arrays?___
A. Fixed
B. Most Recently Used
C. Dynamic
D. isk Morroring
【单选题】
Which command will show the iSCSI sessions on a ESXi 6.5 host?___
A. esxcli storage iscsi session get
B. esxcli iscsi session get
C. esxcli storage iscsi session
D. esxcli iscsi session list
【单选题】
Which of the following is not a parameter for traffic filtering or marking?___
A. virtual port ID
B. Protocol
C. Traffic Direction
D. DSCP value
E. Traffic redirection
【单选题】
A vSphere administrator wants to enable a virtual machine with Secure Boot, but in VM setting, Secure Boot option was not found under Boot Options. What could be the cause?___
A. The virtual hardware is not compatible.
B. The virtual machine has missing drivers.
C. The virtual machine OS does not support secure boot.
D. VMware Tools is not upgraded.
【单选题】
A virtual machine is connected on a distributed port group where the average bandwidth configured in the traffic shaping policy is 100 Mbps. The VM network adapter is configured with a reservation of 200 Mbps. What is the VM’s effective bandwidth?___
A. 200 Mbps
B. 100 Mbps
C. 150 Mbps
D. 400 Mbps
【多选题】
What are two reasons why a datastore in a Storage DRS cluster cannot enter maintenance mode?(Choose two.)___
A. Storage latency is too high to allow Storage DRS initiate Storage vMotion.
B. Storage DRS is configured for a VMFS3 datastore.
C. Storage
D. RS is disabled on the virtual disk.
【多选题】
What two methods are used to configure VMware vSphere Storage I/O Control shares and limits? (Choose two.)___
A. Assign shares and limits to VM virtual disks.
B. Assign shares and limits to datastores.
C. Assign shares and limits to Storage (DRS) clusters.
D. Assign shares and limits using VM storage policies.
【多选题】
ESXi 6.5 introduces VMFS6, which supports both 512e and 512n devices. What three configurations are supported when using these devices? (Choose three.) ___
A. Hosts with both 512e and 512n devices.
B. Storage vMotion between both 512e and 512n devices.
C. Datastore Extents spanned between both 512e and 512n devices.
D. Storage DRS clusters containing only both 512e and 512n devices.
【多选题】
A vSphere Administrator observes that the Primary VM configured with Fault Tolerance is executing slowly. After further investigation, it is determined that the Secondary VM is on an overcommitted ESXi host. What two methods will correct the problem? (Choose two.)___
A. Use Storage vMotion to migrate the Secondary VM to another datastore.
B. Use vMotion to migrate the Secondary VM to a different ESXi host.
C. Configure a CPU limit on the Primary VM which will also apply to the Secondary VM.
D. Turn off and turn on FT in order to recreate the Secondary VM on a different datastore.
【多选题】
Which two features require the use of Host Profiles? (Choose two.)___
A. Host Customizations
B. shared storage
C. Auto
D. eploy
【多选题】
What three processes on the vCenter Server Appliance (VCSA) does“vmware-watchdog monitor? (Choose three.) ___
A. vmware-eam
B. vmcad
C. vmware-vpostgres
D. vpxd
E. vsan-health
【多选题】
What three processes on the vCenter Server Appliance (VCSA) does“vmware-watchdog monitor? (Choose three.) ___
A. vmware-eam
B. vmcad
C. vmware-vpostgres
D. vpxd
E. vsan-health
【多选题】
Which two statements correctly describe VM-Host affinity rules? (Choose two.) ___
A. When there is more than one VM-Host affinity rule in a vSphere DRS cluster, the rules are applied equally.
B. After creating a VM-Host affinity rule, its ability to function in relation to other rules is predetermined.
C. When there is more than one VM-Host affinity rule in a vSphere
D. RS cluster, the rules will be ranked.
【多选题】
An administrator wants to enable proactive HA by moving virtual machines automatically if a hardware alert is triggered. What are the three required settings? (Choose three.)___
A. Set vSphere DRS Automation to Partially Automated.
B. Turn on Proactive HA.
C. Set the Proactive HA Automation Level to Manual.
D. Set the Proactive HA Automation Level to Automated.
E. Turn on vSphere HA and vSphere DRS.
【多选题】
If vCenter Server 5.5 installation has one or more services deployed remotely, which three services are relocated to vCenter Server 6.5 on upgrade? (Choose three.)___
A. vCenter Inventory Services
B. vSphere Authentication Proxy
C. vSphere Web Client
D. vSphere
E. SXi Dump Collector
【多选题】
What two debugging levels can a virtual machine be configured to? (Choose two.)___
A. Verbose
B. Debugging
C. Statistics
D. Trivia
【多选题】
What are three benefits of using a few large-capacity LUNs instead of many small-capacity LUNs? (Choose three.) ___
A. Better performance because there is less contention for a single volume.
B. More flexibility for resizing virtual disks.
C. Less wasted storage space.
D. More flexibility to create virtual machines without adding new LUNs.
E. Fewer VMFS datastores to manage.
【多选题】
Which two configurable options are available in Boot Options for a virtual machine? (Choose two.)___
A. Tools Upgrades
B. Encryption
C. Firmware
D. Force BIOS setup
【多选题】
Which three VMware-recommended best practices should an administrator follow before upgrading to vSphere 6.5? (Choose three.)___
A. Disconnect ESXi host from vCenter.
B. VMware Tools are installed in the virtual machine.
C. Ensure that the system hardware complies with ESXi requirements.
D. Back up the host.
E. Check the interoperability of any other software integrated with vSphere.
【多选题】
What are two requirements to enable EVC in vSphere DRS cluster? (Choose two.)___
A. CPUs must be from the same vendor.
B. EVC must use the lowest possible baseline supported by the hardware.
C. CPUs must be in the same family and of the same speed.
D. No VMs may be running in the cluster.
【多选题】
What three conditions could result in VMware Flash Read Cache being unable to claim a disk? (Choose three.)___
A. The disk is not listed in the VMware hardware compatibility guide.
B. The disk is not detected as an SSD.
C. The disk is not detected as local.
D. The disk is in use by VMFs.
【多选题】
Boot from SAN is supported on which three storage technologies? (Choose three.)___
A. VMware vSAN
B. FCoE
C. NFS 4.1
D. iSCSI
E. FC
【多选题】
Which two components are part of storage I/O multipathing on ESXi? (Choose two.)___
A. SATP
B. VASA
C. PSP
D. VAAI
【多选题】
Which two statements are true about Highly Available vSphere Auto Deploy infrastructure? (Choose two.)___
A. It helps prevent data loss.
B. It is a prerequisite for using vSphere Auto Deploy with stateful install.
C. It requires two or more Auto
D. eploy servers.
【多选题】
The virtual machine log rotation size can be changed for all VMs by which two interfaces? (Choose two.)___
A. PowerCLI
B. vSphere Web Client
C. ESXi host client
D. esxcli
【多选题】
Which two configuration options can exclude virtual disks from snapshot operations? (Choose two.)___
A. Use RDM in virtual mode for virtual disk.
B. Use virtual disks in Independent – Persistent mode.
C. Use a virtual disk larger than 2 TB in size.
D. Use RDM in physical mode for virtual disk.
【多选题】
Which two storage configurations on the source server are unsupported with VMware Converter? (Choose two.)___
A. Linux LVM
B. software RAID
C. GPT/MBR hybrid disks
D. Windows basic volumes
E. Windows dynamic volumes
【多选题】
Which two statements about vCenter HA are correct? (Choose two.)___
A. ESXi 5.5 or later is required.
B. vCenter HA network latency between nodes must be less than 50 ms.
C. NFS datastore is supported.
D. It must be deployed on a 3
E. SXi host cluster with DRS enabled.
【多选题】
An attempt to delete NFS datastore from a ESXi host returns the error: Sysinfo error on operation returned the following status:< Busy> Which two statements could explain this failure? (Choose two.)___
A. NFS datastore is a part of Storage DRS Cluster.
B. NFS.VolumeRemountFrequency value is set to 30.
C. Storage I/O Control is enabled on NFS datastore.
D. NFS datastore has running or registered virtual machines.
