【多选题】
以下达希纳主信息包括（ ）。
A. 达希纳是专为CML设计的二代TKI，强效精准抑制BCR-ABL
B. 达希纳更快获得更深缓解，减少疾病进展
C. 达希纳耐受性好，不良反应可预测，易管理
D. 达希纳有150mg，200mg2种剂型，方便患者使用
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相关试题
【多选题】
以下关于DASISION研究的描述，正确的是（ ）。
A. DASISION试验的研究终点是CCyR，而不是MMR
B. DASISION试验中，达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中，达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
以下哪个说法是正确的是（ ）。
A. 所有TKI由于抑制野生型Bcr-Abl，都会对心血管系统产生影响
B. 临床试验证实：达希纳治疗患者的心血管事件发生率与同年龄组普通人群相似
C. 所有进行TKI治疗的CML患者，都应该进行心血管风险因素的评估
D. 所有选项均不正确
【多选题】
以下英文缩写与中文正确对应的是（ ）
A. PCyR：部分细胞遗传学反应
B. CCyR：完全细胞遗传学反应
C. MMR：主要分子学反应
D. 所有选项均不正确
【多选题】
由于药物相互作用，服用达希纳时，应该避与（ ）同时使用。
A. 酮康唑
B. 伊曲康唑
C. 伏立康唑
D. 克拉霉素
【多选题】
有研究推荐，晚期CML患者移植后为预防急性移植物抗宿主病（aGVHD），可接受（ ） 治疗。删除
A. 环孢素A
B. 霉酚酸酯
C. 短期甲氨蝶呤
D. 以上所有选项均错误
【多选题】
与伊马替尼相比，达希纳作为一线治疗的优势是（ ）。
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 所有选项均不正确
【多选题】
在ENESTnd研究随访6年时，CML患者死亡最常见的原因为
A. 晚期CML
B. 疾病进展
C. 肺炎
D. 心血管事件
【多选题】
"在ENESTnd研究中接受伊马替尼核心治疗反应欠佳/治疗失败的患者换用达希纳400 mg BID后患者达到CCyR和MMR的比例分别为
A. 0.58
B. 0.6
C. 0.32
D. 0.42
【多选题】
在TIDEL-II研究中，服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在titel - ii研究中，73例接受大剂量伊马替尼治疗的患者其原因为
A. 伊马替尼不耐受
B. 未达分子里程碑
C. 丧失反应
D. 经济因素
【多选题】
在达希纳给药前必须纠正（ )，在治疗期间必须其血药浓度进行定期检测。
A. 有临床表现的脱水并治疗高尿酸血症
B. 低钾血症
C. 低镁血症
D. 高钾血症
【多选题】
在达希纳治疗前应对（ ）进行评估，并在治疗过程中有临床指征时进行评估。
【多选题】
早期的分子学反应（3个月时Bcr-Abl 水平）与以下哪个长期预后相关？
A. 疾病进展风险
B. 总生存率
C. MR4.5 率
D. 所有选项均不正确
【多选题】
中国CML指南推荐，对妊娠期间确诊的女性CML-CP患者，应尽可能避免（ ） 具有致畸可能的药物。
A. TKI
B. 羟基脲
C. 白消安
D. 以上所有选项均错误
【多选题】
ENESTnd研究中，排除（）类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
NCCN指南推荐：伊马替尼治疗中疾病进展至BC期的患者，可采取（）治疗。
A. 临床试验
B. AML或ALL诱导化疗+TKI后HSCT（如可行）
C. TKI后HSCT（如可行）
D. 以上所有选项均错误
【多选题】
TKI治疗的CV风险管理中，属于不可更改的因素有（）。
【多选题】
达希纳的适应症为（）？
A. 用于治疗新诊断的费城染色体阳性的慢性髓性白血病（Ph+CML）慢性期成人患者。
B. 用于对既往治疗（包括伊马替尼）耐药或不耐受的费城染色体阳性的慢性髓性白血病（Ph+CML）
C. 初诊为费城染色体阳性的慢性髓性白血病（Ph+ CML）的慢性期成人患者
D. 以上均不正确
【多选题】
达希纳能够抑制（）激酶的自磷酸化。
A. Bcr-Abl（20-60nM）
B. PDGFR（69nM）
C. 初诊为费城染色体阳性的慢性髓性白血病（Ph+ CML）的慢性期成人患者 (*)
D. c-Kit（210nM）
【多选题】
服用达希纳时，任何时候都应该避免进食（）
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
符合（）其中任何一项，即可判断为CML加速期。
A. 外周血或骨髓中原始细胞占0.10-0.19
B. 外周血嗜碱粒细胞≥0.20
C. 与治疗无关的持续血小板减少或白细胞计数增高
D. 克隆演变
【多选题】
符合（）其中任何一项，即可诊断为CML急变期。
A. 外周血或骨髓中原始细胞大于等于0.20
B. 骨髓活检原始细胞聚集
C. 髓外原始细胞浸润
D. 所有选项均不正确
【多选题】
关于ENESTnd和ENESTchina研究，以下说法正确有（）。
A. ENESTnd是3臂试验，ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTnd中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
根据中国CML指南2013年版，CML慢性期标准为（）。
A. 外周血或骨髓中原始细胞<0.10
B. 外周血或骨髓中原始细胞≥0.20
C. 髓外原始细胞浸润
D. 未达到诊断加速期或急变期的标准
【多选题】
哪些属于非血液学不良反应（）。
A. 中性粒细胞减少症
B. 胃肠道异常
C. 皮疹
D. 肌痛
【多选题】
以下达希纳主要信息包括（ ）。
A. 达希纳是专为CML设计的二代TKI，强效精准抑制BCR-ABL
B. 达希纳更快获得更深缓解，减少疾病进展
C. 达希纳耐受性好，不良反应可预测，易管理
D. 达希纳有150mg，200mg2种剂型，方便患者使用
【多选题】
以下哪个说法是正确的是（）。
A. 所有TKI由于抑制野生型Bcr-Abl，都会对心血管系统产生影响
B. 临床试验证实：达希纳治疗患者的心血管事件发生率与同年龄组普通人群相似
C. 所有进行TKI治疗的CML患者，都应该进行心血管风险因素的评估
D. 所有选项均不正确
【多选题】
有研究推荐，晚期CML患者移植后为预防急性移植物抗宿主病（aGVHD），可接受（）治疗。
A. 环孢素A
B. 霉酚酸酯
C. 短期甲氨蝶呤
D. 以上所有选项均错误
【多选题】
与伊马替尼相比格列卫，达希纳作为一线治疗的优势是（）。
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 所有选项均不正确
【多选题】
在达希纳给药前必须纠正（），在治疗期间必须其血药浓度进行定期检测。
A. 有临床表现的脱水并治疗高尿酸血症
B. 低钾血症
C. 低镁血症
D. 高钾血症
【多选题】
早期的分子学反应（3个月时Bcr-Abl水平）与以下哪个长期预后相关？
A. 疾病进展风险
B. 总生存率
C. MR4.5
D. 所有选项均不正确
【多选题】
中国CML指南推荐，对妊娠期间确诊的女性CML—CP患者，因有时白细胞分离术不能满意地控制血小板计数，故可予以（）抗凝。
A. 阿司匹林
B. 低分子肝素
C. 维生素K3
D. 以上所有选项均错误
【多选题】
2013 ELN 推荐切换至二代TKI3个月时BCR-ABLIS ≤ 1% 被认为达到最佳反应。
【多选题】
2013版中国CML指南推荐：移植后3月起TKI治疗1年，预防复发。
【多选题】
2016中国CML指南定义一线格列卫治疗失败的标准为，任何时间丧失CHR或CCyR或MMR，出现伊马替尼或其他TKI耐药性突变，出现Ph染色体基础上其他克隆性染色体异常。
【多选题】
2016中国CML指南定义一线格列卫治疗失败的标准为12个月未达到CCyR。
【多选题】
2016中国CML指南定义一线格列卫治疗失败的标准为18个月未达到CCyR。
【多选题】
2016中国CML指南定义一线格列卫治疗失败的标准为3个月无任何CyR。
【多选题】
2016中国CML指南定义一线格列卫治疗失败的标准为6个月未达到CCyR。
【多选题】
2016中国CML指南定义一线格列卫治疗最佳反应的标准为12个月达到CCyR或BCR-ABL（IS）≤1%。
推荐试题
【单选题】
Q2: Why did some stores open at midnight on Thanksgiving night?___
A. To attract young customers .
B. To beat other stores for sale.
C. To let people sleep late the next day .
D. To keep people stay up for the night .
【单选题】
Q3: How many Black Friday shoppers were reported to go to the shops at midnight this year?___
A. 24 percent .
B. 37 percent .
C. 9.5 percent .
D. 23.5 percent .
【单选题】
Q4: What can we learn about the 15-year-old Jenny?___
A. She and her cousins went back home at midnight .
B. She liked the traditional 4 a.m. Black Friday.
C. She preferred midnight shopping to early morning shopping .
D. She and her cousins got up very early to buy discounted items .
【单选题】
Q1: Why did the woman decide to do a triathlon?___
A. Because she did it in college .
B. Because she wanted to be tough .
C. Because her sister did it and liked it .
D. Because her sister said it was good for her .
【单选题】
Q2: When did the man first do a triathlon?___
A. Last year .
B. In college .
C. Last week .
D. In high school .
【单选题】
Q3: How does the man feel about running?___
A. Boring.
B. Scaring .
C. Exciting .
D. Interesting .
【单选题】
Q4: Why doesn’t the woman like swimming in the triathlon?___
A. Because she fears that a big fish might eat her .
B. Because she fears that she would get lost in lakes .
C. Because she doesn't want to scare away small fishes .
D. Because she doesn't like swimming with many people .
【单选题】
Q1: What is the ratio of positive to negative emotions that can make a person happier?___
A. 1:3.
B. 3 :1.
C. 1 :10 .
D. 10 :1.
【单选题】
Q2: What is the most exciting finding about increasing positive emotions?___
A. It improves relationships .
B. It leads to greater success .
C. It helps develop creativity .
D. It contributes to good health .
【单选题】
Q3: What does the speaker say about negative feelings?___
A. People should turn every negative feeling around .
B. Negative feelings can sometimes have positive effects .
C. Negative feelings often cause people to make mistakes .
D. People should never show negative feelings in public places .
【单选题】
Q4: What is the main idea of the passage?___
A. People should learn to manage their emotions .
B. People should be patient with their negative feelings .
C. People should learn to analyze causes of unhappiness .
D. People should identify as many positive feelings as possible .
【单选题】
Q1: What are the man and woman talking about?___
A. Whether nature is magical and kind .
B. Whether nature is powerful and full of risks .
C. Whether Christopher was well prepared for the trip .
D. Whether Christopher's trip to Alaska was worthwhile .
【单选题】
Q2: What can we learn about Christopher?___
A. He made a film about his trip to Alaska .
B. He wrote a story about his trip to Alaska .
C. He died while having an adventure in Alaska .
D. He learned how powerful and risky Alaska was .
【单选题】
Q3: What does the woman think about Christopher taking the trip to Alaska?___
A. He was too foolish .
B. He was really romantic .
C. He had a very kind heart .
D. He had a spirit for trying things .
【单选题】
Q4: Which of the following is NOT mentioned as something that would have saved Christopher’s life?___
A. A gun to hunt .
B. The map of the area .
C. Emergency food supplies .
D.
E. mergency communication equipment .
【单选题】
Q1: What speed can an avalanche reach within five seconds of taking off?___
A. At 8 miles an hour .
B. At 18 miles an hour .
C. At 80 miles an hour .
D. At 88 miles an hour .
【单选题】
Q2: According to the passage, under what circumstances may an avalanche occur?___
A. There are too many layers of snow on the .
B. There is a layer of snow covering an entire area .
C. The top layer of snow slides off the layer below it .
D. The layer of snow below the surface becomes unstable .
【单选题】
Q3: What are skiers advised to do to avoid being caught in an avalanche?___
A. Ski only in the official ski areas .
B. Look for solid snow to walk on .
C. Look out for each other while skiing .
D. Learn to control themselves in an avalanche .
【单选题】
Q4: Why does the ski patrol use explosives?___
A. To dig holes in the snow .
B. To close the area for skiing .
C. To make an avalanche move on purpose .
D. To' check how different layers are holding up .
【单选题】
Q1:What is conversation mainly about?___
A. The woman's happy college life the man's doubt .
B. The woman's spending habits and the man's concerns .
C. The man's reminding the woman of the exam this Thursday .
D. The man's support for the woman over the past 15 years .
【单选题】
Q2:What did the woman do last night?___
A. She bought a new leather coat .
B. She studied very hard for an exam .
C. She treated all her friends to dinner .
D. She went to a concert with her friends .
【单选题】
Q3:Where did the woman get the money?___
A. She just received her student loan .
B. She saved some money for herself .
C. She borrowed the money from her friends .
D. She asked her mom to send her the money .
【单选题】
Q4:What is the man?___
A. A teacher of biology .
B. An undergraduate student .
C. A freshman in biology class .
D. A graduate teaching assistant .
【单选题】
Q1: What is this passage mainly about?___
A. How businesses can compete with each other .
B. How small businesses operate during holidays .
C. How small businesses manage holiday workers .
D. How can earn more money during holidays .
【单选题】
Q2: According to Rubin, what can small companies do to thank holiday workers?___
A. Have talks with their families .
B. Give them good extra benefits .
C. Offer them expensive holiday tokens .
D. Show appreciation to them face to face .
【单选题】
Q3: What can small business owners do to help holiday workers get into the holiday spirit?___
A. Entertain them with big meals .
B. Let them enjoy some holiday games .
C. Give them handmade thank-you cards .
D. Send their families some holiday gift cards .
【单选题】
Q4: Who are supposed to benefit most from this passage?___
A. Workers who have to work during holidays .
B. Employees who intend to earn extra money .
C. Big companies that usually close on holidays .
D. Small businesses that try to be more competitive .
【单选题】
In the first two paragraphs of the passage the writer tries to tell us that___
A. he had lived in Washington D.C. for twenty years
B. he was very imaginative when he was a child
C. he had fond memories of his old neighborhood
D. )he had come from a very poor neighborhood
【单选题】
The writer ,as a child ,was very fond of playing in the basement because ___
A. it was bright and alive
B. it contained a movie house and a space station
C. it was ideal for playing hide-and-seek
D. it was surrounded by trees and flowers
【单选题】
How did the writer feel when he visited his old neighborhood in Washington D.C. ?___
A. Greatly surprised .
B. Very regretful .
C. Quite excited .
D. Very sad .
【单选题】
On his visit to his hometown ,the writer found the old apartment building___
A. see medunfit to live in
B. had been repaired
C. could hardly be recognized
D. looked dirty and smelt horrible
【单选题】
" Youcan never go home again "inthe last sentence of this passage means that___
A. one should never revisit his hometown after many years of absence
B. one will never find his hometown the same as it was in his childhood memory
C. avisit to one's hometown will bring back one's fond memories of home
D. avisit to one's hometown will bring back many sad memorie
【单选题】
We learn from the passage that Tracy died___
A. on December 8,1992
B. of brain damage
C. 24 hours after he fell off the roof of a car
D. in a car crash
【单选题】
Tracy's parents decided to donate Tracy's organs because___
A. Tracy told them to do so just before he died
B. they wanted to save others the pain of seeing a dear one die
C. David's life could continue in a meaningful way
D. they knew David was suffering from a hopeless liver disease
【单选题】
The meeting between the writer's family and Tracy's parents was arranged because___
A. the writer and her husband wished to express their thanks to Tracy's parents
B. the local organ bank wanted to see how both families felt about the donation
C. Tracy's parents wanted to see someone whose life had been saved by the donation
D. the two families were linked by the most bittersweet ties imaginable
【单选题】
The writer and her husband learned how Tracy died___
A. from his parents
B. from the organ bank
C. from the hospital
D. from the doctor who performed the operation
【单选题】
The meeting between the two families helped to ease the Marshes'suffering because___
A. they saw that David looked very much like their son
B. they saw that David had regained health with Tracy's liver
C. they now had someone to share their memories of Tracy
D. they now knew for sure they had done the right thing
【单选题】
The writer's first marriage was unsuccessful because___
A. her husband often woke her up at midnight
B. her husband kept criticizing her
C. she was so unattractive
D. she had a self-esteem problem
【单选题】
When the writer asked for a divorce ,her husband___
A. told her that she would never find one who loved her as he did
B. delayed two years before giving her a reply
C. accused her of having an affair
D. said that she was unattractive and not worth loving
【单选题】
When the writer first met Clint ,she felt that___
A. she should have listened to her friend and met Clint earlier
B. Clint was a nice ,dazzling young man
C. Clint could not be really interested in her
D. she would find true love in Clint
