【多选题】
达希纳含有乳糖，所以对于（ ）的患者，不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
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相关试题
【多选题】
达希纳能够抑制（ ）激酶的自磷酸化。
A. Bcr-Abl（20-60nM）
B. PDGFR（69nM）
C. Src
D. c-Kit（210nM）
【多选题】
达希纳说明书对伊马替尼不耐受的定义是（ ）：
A. 尽管采用了最佳支持治疗，在任何剂量和/或治疗期间，患者仍由3或4级不良事件的持续存在而中止伊马替尼治疗。
B. 尽管采用了最佳的支持治疗，与伊马替尼治疗相关的2级不良事件仍持续时间≥1个月，或反复发生超过3次，不论是否剂量减少或中止治疗。
C. 尽管采用了最佳支持治疗，在任何剂量和/或治疗期间，患者仍由1或2级不良事件的持续存在而中止伊马替尼治疗。
D. 尽管采用了最佳的支持治疗，与伊马替尼治疗相关的2级不良事件仍持续时间≥3个月，或反复发生超过3次，不论是否剂量减少或中止治疗。
【多选题】
对伊马替尼治疗中女性CML患者计划妊娠并生产后的管理描述正确的是：（ ） 。删除
A. 若处于CMR或MMR，不予治疗
B. 若丧失CMR或MMR，考虑治疗
C. 若丧失CHR，需予以治疗
D. 以上所有选项均错误
【多选题】
对伊马替尼治疗中意外妊娠的女性患者的推荐处理描述正确的是：（ ） 。
A. 立即中断服用伊马替尼，以避免或减少药物潜在的致畸毒性
B. 孕3个月以上者继续服药并继续妊娠，同时严密监测胎儿发育情况，一旦发现可识别的显著异常则终止妊娠
C. 尽管已有不少发现怀孕后仍持续服用伊马替尼并产出正常婴儿的案例，但需警惕的是，母亲在妊娠的前三个月内接触伊马替尼对胎儿致畸的风险较大
D. 以上所有选项均错误
【多选题】
对于达希纳停药研究的描述，下列哪项正确
A. 丧失MMR的患者重启原剂量达希纳治疗后仍能很快重新获得分子学反应
B. 持续随访将继续评估尼达希纳长期停药后的持续缓解情况
C. 停药应在严格管理的TFR研究中进行
D. 以上均不正确
【多选题】
服用达希纳时，任何时候都应该避免进食（ ）。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
服用达希纳时，应注意的事项有（ ）。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
符合（ ）其中任何一项，即可判断为CML加速期。
A. 外周血或骨髓中原始细胞占0.10-0.19
B. 外周血嗜碱粒细胞≥0.20
C. 与治疗无关的持续血小板减少或白细胞计数增高
D. 克隆演变
【多选题】
符合（ ）其中任何一项，即可诊断为CML急变期。
A. 外周血或骨髓中原始细胞≥0.20
B. 骨髓活检原始细胞聚集
C. 髓外原始细胞浸润
D. 所有选项均不正确
【多选题】
根据ELN指南，达到满意疗效的Bcr-Abl转录本的水平是（ ）。
A. TKI 治疗3个月，Bcr-Abl ： ≤ 10%
B. TKI 治疗6个月，Bcr-Abl ： ≤ 1%
C. TKI 治疗12个月，Bcr-Abl ：≤0.1%
D. 所有选项均不正确
【多选题】
根据NCCN指南V4.2018，换用其他TKI药物治疗的指征包括
A. 随访3个月，BCR-ABLIS > 10%
B. 随访6个月，BCR-ABLIS > 10%
C. 随访12个月BCR-ABLIS 1%-10%
D. 随访＞12个月BCR-ABLIS > 1%
【多选题】
根据中国CML指南2016年版，CML慢性期标准为（ ）。
A. 外周血或骨髓中原始细胞＜0.10
B. 外周血或骨髓中原始细胞≥0.20
C. 髓外原始细胞浸润
D. 未达到诊断加速期或急变期的标准
【多选题】
关于ENESTnd和ENESTchina 研究, 以下说法正确有（ ）。
A. ENESTnd是3臂试验，ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTnd中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
接受伊马替尼治疗的生产后的女性患者，（ ）。
A. 母乳中无伊马替尼代谢物
B. 母乳中存在伊马替尼代谢物
C. 可哺乳
D. 避免哺乳
【多选题】
目前移植存在的问题是（ ） 。
A. 移植后患者生存率逐年下降
B. 复发率逐年上升
C. 死亡率逐年上升
D. 以上所有选项均错误
【多选题】
哪些属于非血液学不良反应（ ）。
A. 中性粒细胞减少症
B. 胃肠道异常
C. 皮疹
D. 肌痛
【多选题】
哪些属于血液学不良反应（ ）。
A. 血小板减少症
B. 中性粒细胞减少症
C. 腹泻
D. 贫血
【多选题】
评价二代TKI做为新诊断CML-CP患者一线治疗疗效和安全性研究的临床试验包括（ ）。
A. ENESTnd
B. ENESTchina
C. DASISION
D. ENESTcmr
【多选题】
如果出现血液学毒性( )，应暂停达希纳的使用。
A. 加速期：ANC<0.5×109/升或血小板<10×109/升
B. 慢性期：ANC<1.0×109/升或血小板<50×109/升)
C. 加速期：ANC<1×109/升或血小板<10×109/升
D. 慢性期：ANC<10×109/升或血小板<50×109/升
【多选题】
如果临床需要，达希纳可与造血生长因子或其他联用，例如（ ）。
A. EPO
B. G-CSF
C. 羟基脲
D. 阿那格雷
【多选题】
使用Sokal风险评分将Ph+ CML患者分层为高度风险，中度风险和低度风险类别，其基于具有预后意义的独立因子包括
A. 患者
B. 脾肿大程度
C. 血小板计数
D. 外周原始细胞百分比
【多选题】
属于CYP3A4诱导剂的是（ ）。
A. 利福平
B. 卡马西平
C. 苯巴比妥
D. 贯叶连翘
【多选题】
下列哪项是ENESTFreedom研究TFR期的PCR检测频率
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
下列哪项是达到MR4.5的意义
A. 无疾病进展风险
B. 远期生存延长
C. 具备TFR可能
D. 以上都不是
【多选题】
下列哪项是达希纳停药研究TFR期可能出现的不良事件
A. 骨骼肌肉痛
B. 体液潴留
C. 皮疹
D. 心血管事件
【多选题】
下列哪项是达希纳停药研究巩固期可能出现的不良事件
A. 骨骼肌肉痛
B. 胰腺炎
C. 皮疹
D. 心血管事件
【多选题】
相比格列卫，达希纳一线治疗的哪项优势与TFR相关
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 以上均不正确
【多选题】
以下（ ）情况需要慎用达希纳。
A. 长QT综合征
B. 肝损害，电解质紊乱
C. 胰腺炎，严重的糖尿病
D. 所有选项均不正确
【多选题】
以下达希纳主信息包括（ ）。
A. 达希纳是专为CML设计的二代TKI，强效精准抑制BCR-ABL
B. 达希纳更快获得更深缓解，减少疾病进展
C. 达希纳耐受性好，不良反应可预测，易管理
D. 达希纳有150mg，200mg2种剂型，方便患者使用
【多选题】
以下关于DASISION研究的描述，正确的是（ ）。
A. DASISION试验的研究终点是CCyR，而不是MMR
B. DASISION试验中，达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中，达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
以下哪个说法是正确的是（ ）。
A. 所有TKI由于抑制野生型Bcr-Abl，都会对心血管系统产生影响
B. 临床试验证实：达希纳治疗患者的心血管事件发生率与同年龄组普通人群相似
C. 所有进行TKI治疗的CML患者，都应该进行心血管风险因素的评估
D. 所有选项均不正确
【多选题】
以下英文缩写与中文正确对应的是（ ）
A. PCyR：部分细胞遗传学反应
B. CCyR：完全细胞遗传学反应
C. MMR：主要分子学反应
D. 所有选项均不正确
【多选题】
由于药物相互作用，服用达希纳时，应该避与（ ）同时使用。
A. 酮康唑
B. 伊曲康唑
C. 伏立康唑
D. 克拉霉素
【多选题】
有研究推荐，晚期CML患者移植后为预防急性移植物抗宿主病（aGVHD），可接受（ ） 治疗。删除
A. 环孢素A
B. 霉酚酸酯
C. 短期甲氨蝶呤
D. 以上所有选项均错误
【多选题】
与伊马替尼相比，达希纳作为一线治疗的优势是（ ）。
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 所有选项均不正确
【多选题】
在ENESTnd研究随访6年时，CML患者死亡最常见的原因为
A. 晚期CML
B. 疾病进展
C. 肺炎
D. 心血管事件
【多选题】
"在ENESTnd研究中接受伊马替尼核心治疗反应欠佳/治疗失败的患者换用达希纳400 mg BID后患者达到CCyR和MMR的比例分别为
A. 0.58
B. 0.6
C. 0.32
D. 0.42
【多选题】
在TIDEL-II研究中，服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在titel - ii研究中，73例接受大剂量伊马替尼治疗的患者其原因为
A. 伊马替尼不耐受
B. 未达分子里程碑
C. 丧失反应
D. 经济因素
推荐试题
【多选题】
Which two statements are true for NFS v4.1 firewall behavior? (Choose two.)___
A. It closes port 2049.
B. It sets allowed. All flag to TRUE.
C. It sets allowed. All flag to FALSE.
D. It opens port 2049.
【多选题】
A vSphere Administrator attempts to enable Fault Tolerance for a virtual machine but receives the following error: Secondary VM could not be powered on as there are no compatible hosts that can accommodate it. What two options could cause this error? (Choose two.)___
A. The other ESXi host(s) are in Maintenance Mode.
B. Hardware virtualization is not enabled on the other ESXi host(s).
C. The other ESXi host(s) are in Quarantine Mode.
D. Hardware MMU is enabled on the other
E. SXi host(s).
【多选题】
Storage capabilities be populated in what two ways? (Choose two.)___
A. The administrator can use tags to describe capabilities.
B. Default capabilities are provided by vCenter Server.
C. Datastores can advertise their capabilities through VAAI.
D. Datastores can advertise their capabilities through VASA.
【多选题】
In network troubleshooting it is important to know what upstream switch the ESXi host is connected to. Which two features does ESXi provide to help identify the upstream switch? (Choose two.)___
A. Promiscuous mode
B. DPM
C. LLDP
D. CDP
【多选题】
Virtual Volumes supports which three VMware features? (Choose three.)___
A. Instant Clones
B. Distributed Resource Scheduler
C. Linked Clones
D. vMotion
E. Storage Distributed Resource Scheduler
【多选题】
vSphere DRS helps to balance virtual machines with available resources in a vSphere cluster. What three types of resources can be taken into account for balancing? (Choose three.)___
A. CPU
B. physical NIC saturation of an ESXi host
C. virtual NIC saturation of a virtual machine
D. RAM
E. storage latency
【多选题】
Which three design requirements must be satisfied to enable RAID-6 objects in a VMware vSAN cluster? (Choose three.)___
A. vSAN Advanced license or higher
B. vSAN stretched cluster
C. at least six hosts contributing storage
D. deduplication and compression
E. all flash configuration
【多选题】
When using "Cluster resource percentage" for host failover capacity in vSphere HA Admission Control, the total resource requirements are calculated from which two values? (Choose two.)___
A. Total vCPUs assigned to each VM.
B. Average CPU usage on each VM over time.
C. Memory reservations on each VM.
D. Total memory assigned to each VM.
E. Average active memory on each VM over time.
F. CPU reservations on each VM.
【多选题】
Which are four attributes of the Active vCenter HA node? (Choose four)___
A. It uses the vCenter HA network to communicate with the Witness node.
B. It constantly replicates vPostgres data with the Witness node.
C. It uses a public IP address for the management interface.
D. It runs the active vCenter Server Appliance instance.
E. It uses the vCenter HA network for replication of data to the Passive node.
F. It provides a quorum to protect against split-brain situations.
【多选题】
Which are two vCenter Server two-factor authentication methods? (Choose two.)___
A. RSA SecurID
B. Smart Card
C. SAML
D. Symantec VIP
【多选题】
An administrator is creating VMkernel adapters on an ESXi 6.5 host and wants to create separate VMkernel adapters for every type of traffic in the default TCP/IP stack. Which three types of traffic can be explicitly enabled on a separate VMkernel adapter? (Choose three.)___
A. Virtual SAN traffic
B. NFS traffic
C. vMotion traffic
D. vSphere HA traffic
E. Fault Tolerance logging traffic
【多选题】
When migrating a Windows vCenter Server 6.0 to the vCenter Server Appliance 6.5, which two will be migrated by default? (Choose two.)___
A. Local Windows OS users and groups
B. Configuration
C. Custom ports
D. FQDN
E. Historical and Performance data
【多选题】
Which three types of Content Libraries exist within vSphere 6.5? (Choose three.)___
A. Remote Content Library
B. Published Content Library
C. Local Content Library
D. Shared Content Library
E. Subscribed Content Library
【多选题】
An administrator cannot enable multi-processor Fault Tolerance (SMP-FT) for a virtual machine. Which are two possible causes for this? (Choose two.)___
A. The virtual machine is running on a vSAN datastore.
B. The Fault Tolerance network is using a 10Gbit uplink.
C. The virtual machine has 6 vCPUs assigned.
D. The virtual machine has a 1TB VMDK attached.
E. The virtual machine has snapshots present.
【多选题】
Which two statements are true for Predictive DRS? (Choose two.)___
A. It balances resource utilization for virtual machines with unpredictable utilization patterns.
B. It integrates DRS with vRealize Operations Manager to balance workloads for virtual machines before resource utilization spikes occur.
C. It balances resource utilization based on a threshold's algorithm that runs each night.
D. It determines the best placement and balance of virtual machines based on a threshold's algorithm that runs each night in vCenter Server 6.5 Database.
【多选题】
Which two situations could cause a virtual machine to appear with (orphaned) appended to its name? (Choose two.)___
A. if a host failover is unsuccessful
B. if a virtual machine was removed from vCenter Server's inventory
C. if a virtual machine was deployed from template, and the template has been deleted
D. if a virtual machine is unregistered directly on the host
【多选题】
Which three requirements are needed to apply RAID 5 or RAID 6 erasure coding on a vSAN 6.2 or 6.5 object? (Choose three.)___
A. on Disk Format 3.0
B. Hybrid vSAN
C. All Flash vSAN
D. vSAN Advanced License
E. Stretched Cluster Configurations
【多选题】
An administrator sees the following error in the log files: Which two events could be the source of the error message? (Choose two.)___
A. vCenter Server failure
B. VXLAN failure
C. Disk array failure
D. Network failure
E. ESXi host failure
【多选题】
An administrator is attempting to access an ESXi host via the DCUI but is unable to do so. Which could be two possible causes? (Choose two.)___
A. The host in Qhas no out-of-band management capability (i.e. iLO/iDRAC).
B. The SSH service is disabled on the host.
C. Strict lockdown mode is enabled on the host.
D. Normal lockdown mode is enabled and the administrator is a member of the
E. xception User list.
【多选题】
Which two permissions are required to migrate a virtual machine with Storage vMotion? (Choose two.)___
A. Network > Move Network
B. Virtual Machine > Inventory > Move
C. Resource > Migrate powered on virtual machine
D. Datastore > Allocate Space
【多选题】
Which are three supported storage requirements for vCenter Server HA? (Choose three.)___
A. NFS
B. RDM
C. vSAN
D. VMFS
E. JBOD
【多选题】
Which are the two network requirements for a VMware vSAN 6.5 cluster? (Choose two.)___
A. Multicast must be enabled on the physical switches and routers that handle vSAN traffic.
B. vSAN requires IPv6 only.
C. All hosts must have a dedicated 40GbE NIC.
D. The vSAN network supported IPv4 or IPv6.
E. vSAN requires IPv4 only.
【多选题】
Which three prerequisites must be in place prior to enabling secure boot for a virtual machine? (Choose three.)___
A. VirtualMachine.Config.Settings privileges
B. an encrypted USB drive
C. Virtual Hardware version 13 or later
D. Virtual Hardware version 12 or later
E. EFI firmware
【多选题】
A user is given the "Virtual machine user (sample)" role in a vSphere 6.x environment. Which three permissions would the user be able to perform? (Choose three.)___
A. Reset a virtual machine.
B. Power on a virtual machine.
C. Move a host into a cluster.
D. Configure CD media.
E. Migrate a virtual machine with Storage vMotion.
【多选题】
Which three are supported upgrade processes for ESXi host? (Choose three.)___
A. using vSphere Auto Deploy
B. using a TFTP server
C. using Update Manager
D. using an
E. SXCLI command
【多选题】
When enabling Storage DRS on a datastore cluster, which three components are enabled as a result? (Choose three.)___
A. Space load balancing among datastore within the datastore cluster.
B. Initial placement for virtual disks based on space and I/O workload.
C. I/O load balancing among datastores within the datastore cluster.
D. Queue Depth alerting on disks within the datastore cluster.
E. Data de-duplication within the datastore cluster.
【多选题】
What are two features introduced in Network I/O Control version 3? (Choose two.)___
A. Bandwidth reservation per traffic type
B. Network resource pools
C. CoS tagging
D. Bandwidth guarantee to virtual machines
【多选题】
Which two correct virtual machine advanced configuration parameters will accomplish this? (Choose two.)___
A. isolation.device.edit.disable = “FALSE”
B. isolation.device.edit.disable = “TRUE”
C. isolation.device.connectable.disable = “FALSE”
D. isolation.device.connectable.disable = “TRUE”
【多选题】
Which three statements are correct regarding booting an ESXi Host from Fibre Channel SAN? (Choose three.)___
A. Direct connect topology is supported.
B. Each host must have its own boot LUN.
C. ESXi hosts do not require local storage.
D. Multipathing to a boot LUN on an active-passive array is supported.
E. Hosts can share one common boot LUN.
【多选题】
Which two tasks should a vSphere administrator perform if the vmkernel log reports VMFS metadata errors? (Choose two.)___
A. contact VMware technical support
B. reformat the datastore
C. check the device with VOMA
D. ignore the messages
【多选题】
Which two statements are true for a vCenterServer user account that is used for vSphere Data Protection (VDP)? (Choose two.)___
A. The user account must be assigned with Administrator role.
B. The password for the user account cannot contain spaces.
C. The user account should be created in the Single Sign-On domain
D. The user account cannot inherit required permissions from a group role.
【多选题】
Which three storage protocols are supported by Virtual Volumes? (Choose three.)___
A. FCIP
B. FCoE
C. iSCSI
D. NFS v3
E. NFS v4
【多选题】
A vSphere administrator observes a CPU spike on one of the web servers (view the Exhibit.) Which two statements can describe the cause of this activity? (Choose two.)___
A. The network packet size is too large.
B. VMware Tools is not installed.
C. Disk latency is present on the datastore.
D. The network packet size is too small.
【多选题】
Which three operations can cause VMFS metadata updates? (Choose three.)___
A. Restarting a VM using the guest OS.
B. Launching a VM console.
C. Migrating a VM with vMotion.
D. Powering a VM on or off.
E. Expanding a VMFS datastore.
【多选题】
*What two services run on all nodes in a vCenter Server HA cluster? (Choose two.)___
A. vmware-vmon
B. vmware-vpostgres
C. vmare-rbd-watchdog
D. vmware-vcha
【多选题】
Which two statements are true regarding Auto Deploy in version 6.5? (Choose two.)___
A. Auto Deploy can be configured and managed via PowerCLI.
B. Auto Deploy can be configured and managed via the vSphere Client.
C. Auto
D. eploy can be configured and managed via the vSphere Web Client.
【多选题】
What three options can improve network performance for a virtual machine? (Choose three.)___
A. MLD
B. TSO
C. NetFlow
D. LRO
E. SR-IOV
【多选题】
Which two storage technologies are supported for MSCS? (Choose two.)___
A. NFS
B. VAAI
C. iSCSI
D. FC
【多选题】
When upgrading a VMware vSAN cluster to version 6.5, which two tasks must be completed to comply with upgrade requirements and VMware-recommended best practices? (Choose two.)___
A. Use RVC to upgrade the hosts.
B. Use the latest available ESXi version.
C. Back up all VMs.
D. Use only the “Full data migration” maintenance mode option.
【多选题】
What two enhancements are in VMFS6 but not in VMFS5? (Choose two.)___
A. Support for 4k native disks
B. Support for 512e disks
C. GPT storage device partitioning
D. Automatic space reclamation
