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【单选题】
- This is heavy! What's in it? ___
A. I think you don't like it.
B. My new computer. I just bought it.
C. I'm glad you're here.
D. Are you really interested in it?
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答案
B
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相关试题
【单选题】
___ I'd like to place an order please.
A. Can I help you?
B. I can help you.
C. What are you doing?
D. Why are you doing?
【单选题】
- Do you know the girl over there?___
A. How can I know?
B. Yes, I remember it now.
C. It's Sam, my teacher's daughter.
D. She is a good girl.
【单选题】
- Shall we go out for dinner tonight?____
A. No, you can't.
B. Yes, please.
C. Thank you, I don't want to.
D. Sorry, I have a report to finish.
【单选题】
- I think the reference book(参考书)is very helpful.____
A. Good idea.
B. So do I.
C. With pleasure.
D. No problem.
【单选题】
- I wish you success in your career.____
A. You are welcome.
B. I think so.
C. Yes, please.
D. The same to you.
【单选题】
- Would you like to come over tonight?____
A. Yes, last night.
B. Yes, over there.
C. Sure, I'd love to.
D. Yeah, I liked it too.
【单选题】
- How do I transfer calls? ____
A. Do as you like.
B. It is a bit difficult.
C. Let me show you.
D. Not at all.
【单选题】
- Thanks for inviting me, John, but I've already made other plans. ____. Maybe another time.
A. I hope you enjoy it
B. That's good
C. Oh! I'm sorry to hear that
D. Great! I really had a good time
【单选题】
- Thanks for the lovely party and the delicious food. ____
A. No, thanks.
B. Never mind.
C. Thank you for coming.D.That's all right.
【单选题】
- Why didn't you tell me? ____
A. Sorry, I forgot.
B. I'm sorry you should wait.
C. I don't know.
D. I'd love to.
【单选题】
- What do you plan to do after the exam? ____ How about you?
A. I hate taking exams.
B. I like making plans.
C. Nothing special.
D. I've changed my mind.
【单选题】
- Tom told me that you collect stamps. ____
A. What do you mean?
B. I don't think so.
C. Why did he tell you?
D. Yes, I do. Do you?
【单选题】
- This is a challenging job. Who wants it?____
A. I'll take it.
B. It's a good idea.
C. You bet!
D. No sweat!
【单选题】
- I'm taking my driving test tomorrow. ___!
A. Cheers
B. Good luck
C. Come on
D. Congratulations
【单选题】
- ABC Company, may I help you? ____
A. I am Jack. May I speak to Miss Jenny?
B. This is Jack speaking. May I speak to Miss Jenny?
C. This is Jack speaking. Can I find Miss Jenny?
D. I am Jack. Can I find Miss Jenny?
【单选题】
- You have won the football game. Congratulations! ____
A. We are really lucky.
B. No one else could do it.
C. Oh, not really.
D. It's nice of you to say so.
【单选题】
- Excuse me, when will the 17:15 train arrive____
A. I don't tell you.
B. It's been delayed one hour.
C. You have to be patient.
D. Don't ask me.
【单选题】
- Is John there?____
A. Speaking.
B. I'm not Mary.
C. Who are you?
D. Mary is well today.
【单选题】
- Would you like to join us for Sunday dinner____
A. It's nice of you to invite me.
B. How about the food?
C. I like onion soup.
D. I'm sorry I missed the fun last time.
【单选题】
- Could you tell me where the nearest parking lot is?____
A. Don't ask me.
B. Parking is very difficult.
C. Sorry, I'm a stranger here.
D. Sorry, you can't park here.
【单选题】
- Sorry, ___
A. here you are.
B. take it.
C. it's taken.
D. never mind.
【单选题】
-What's this in English? ____
A. It's a map.
B. That is a map.
C. Yes, it's a map.
D. No, it isn't.
【单选题】
- I hear you got through your exam. Congratulations!____
A. No. I didn't do well enough.
B. Who told you that?
C. Thanks.
D. Yes, I got a good mark.
【单选题】
- Don't forget to come to my party this evening!___
A. I can't.
B. I won't.
C. I don't.
D. I will.
【单选题】
- Jim, please don't put your head out of the window on the bus. It's dangerous!___
A. Good idea.
B. Sorry, I won't do it again.
C. It doesn't matter.
D. It's good.
【单选题】
-How about going fishing?___, I have no patience for that.
A. Excuse me
B. Sorry
C. Pardon
D. Apologize
【单选题】
- Thanks for the lovely and delicious food______.
A. No thanks
B. Never mind
C. All right
D. My pleasure
【单选题】
- Haven't seen you for ages. Let's have a get-together next week._____
A. Great idea.
B. Welcome!
C. Yes, of course.
D. No, thanks.
【单选题】
- Do you mind if I switch off the radio? ______. Go ahead.
A. Never mind
B. No way
C. No, not at all
D. No, you'd better not
【单选题】
- Could I use your bike for a moment? ___
A. It's well.
B. It doesn't matter.
C. By all means.
D. I have no idea.
【单选题】
-How do you like the story?_______.
A. I'd like to read it
B. I like it very much
C. fine, thank you
D. It's very interesting
【单选题】
- I'll sorry to trouble you.______.
A. Don't say so
B. OK
C. It doesn't matter
D. That's fight
【单选题】
- We ordered 20 boxes of your products, but we have only got 19. - ____
A. You do not have to.
B. It does not matter.
C. We will send another tomorrow.
D. Nothing serious.
【单选题】
--Will you please give the note to him? _________.
A. Certainly, I'll give it to him
B. No, please not
C. Sorry, I don't
D. Yes, please do
【单选题】
- Thank you ever so much for your lovely gift____
A. Never mind
B. I'm glad you like it.
C. Please don't say so.
D. No, It's not so good.
【单选题】
- I'd like to invite you to dinner this Saturday, Mr. Smith.____
A. Oh, no. let's not.
B. I'd rather stay at home.
C. I'm sorry, but I have other plans.
D. Oh, no. That'll be too much trouble.
【单选题】
- Could you please open the window?____
A. I can't.
B. Go ahead.
C. Sure.
D. It's really very kind.
【单选题】
- Do you think I can borrow your bike for a few hours?____
A. I'm afraid you can.
B. I'm sorry, but I really need it this afternoon.
C. Yes, I don't think so.
D. I'll think about it later.
【单选题】
- Thank you very much for the dictionary you sent me.____
A. No thanks.
B. I'm glad you like it.
C. Please don't say so.
D. No, it's not so good.
【单选题】
- How do you like the movie we saw yesterday?____
A. You are welcome.
B. How about you?
C. I've never seen a better movie than it.
D. It is very expensive.
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CML患者疾病进展后,中位生存时间不足
A. 2年
B. 6个月
C. 1年
D. 1年3个月
【多选题】
CML预后分析Sokal积分公式中包含( )等预后因素。
A. 年龄、脾脏大小、血小板、原始细胞
B. 年龄、脾脏大小、血小板、嗜酸性细胞百分数
C. 年龄、脾脏大小、血小板、嗜碱性细胞百分数
D. 以上所有选项均错误
【多选题】
CML诊断标准包括( )。
A. 典型的临床表现
B. 有Ph染色体
C. 有BCR-ABL融合基因阳性
D. 典型的临床表现,有Ph染色体和/或有BCR-ABL融合基因阳性
【多选题】
CML治疗的首要目标是使患者维持在( )。
A. 加速期
B. 慢性期
C. 急变期
D. 以上均不正确
【多选题】
CML治疗反应的监测方法包括( )?
A. "全血细胞计数
B. 骨髓细胞遗传学分析
C. 实时定量聚合酶链反应检测(RQ-PCR)
D. 以上均正确
【多选题】
DASISION 研究4年随访中,22%的达沙替尼治疗患者中经常报告的不良事件是()。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
DASISION研究的终点是( )。
A. 6个月内,证实获得的CCyR
B. 12个月内,证实获得的CCyR
C. 6个月内,证实获得的MMR
D. 12个月内,证实获得的MMR
【多选题】
DASISON 研究中,达沙替尼胸腔积液的复发率是( )。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
ELN推荐,获得MMR的患者,应每( )进行常规IS RQ-PCR监测。
A. 3-6个月
B. 6-12个月
C. 8-10个月
D. 1-2个月
【多选题】
ELN推荐,治疗12个月时的最佳疗效反应为( )。
A. BCR-ABL≤10%和/或CCyR( 0%到35%,Ph+ 染色体)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐,治疗3个月时的最佳疗效反应为( )。
A. BCR-ABLIS≤10%和/或PCyR(0%到35%,Ph+中期分裂)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐,治疗6个月时的最佳疗效反应为( )。
A. BCR-ABL≤10%和/或PCyR(0%到35%,Ph+ 中期分裂)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐患者应该进行常规IS RQ-PCR监测,每( )个月一次,直至获得MMR。
A. 1
B. 2
C. 3
D. 4
【多选题】
EMA 2006年颁布指南:每天摄入遗传毒性杂质应( )。
A. ≤1.5微克
B. =1.5微克
C. >1.5微克
D. 以上所有选项均错误
【多选题】
EMA是指( ) 。
A. 欧洲药品管理局
B. 欧洲白血病网
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
ENESTchina的主要研究终点是( )。
A. 12个月的MMR,定义为BCR-ABL≤0.1%
B. 6个月的MMR,定义为BCR-ABL≤0.1%
C. 24个月的MMR,定义为BCR-ABL≤0.1%
D. 36个月的MMR,定义为BCR-ABL≤0.1%
【多选题】
ENESTchina中,中国CML 发病的中位年龄是( )。
A. 55
B. 60
C. 40
D. 71
【多选题】
ENESTcmr研究中,与使用伊马替尼相比, 使用达希纳实现首次MR4.5的中位时间缩短了
A. 3个月
B. 6个月
C. 1年
D. 2年
【多选题】
ENESTFreedom研究中,巩固期PCR检测频率为
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
ENESTFreedom研究中,停药后48周维持TFR的患者比例为
A. 0.442
B. 0.516
C. 0.589
D. 0.56
【多选题】
ENESTFreedom研究中,重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
ENESTFreedom研究中,重启治疗的标准是
A. 丧失MR4.5
B. 丧失MMR
C. 丧失CCyR
D. 疾病进展
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENESTnd 研究随访到5年时,达希纳300mgBID和伊马替尼组的患者中,达到MR4.5的患者的百分比是多少?
A. 32%、15%
B. 40%、 23%
C. 42%、 24%
D. 54%、 31%
【多选题】
ENESTnd 研究中,达希纳300mg BID 和伊马替尼组患者在12个月时累计的MMR率是多少?
A. 40% 和 23%
B. 54% 和 31%
C. 60% 和 31%
D. 55% 和 27%
【多选题】
ENESTnd 研究中,达希纳300mg BID 和伊马替尼组患者在三个月没有达到BCR-ABL ≤ 10%的百分比是多少?
A. 7% 和 29%
B. 7% 和 30%
C. 9% 和 30%
D. 9% 和 33%
【多选题】
ENESTnd 研究中,达希纳300mg BID 和伊马替尼组患者在以下哪个milstone的百分比分别为91%和 67%?
A. 6个月Bcr-Abl ≤ 1%
B. 6个月Bcr-Abl > 1%
C. 3个月Bcr-Abl ≤ 10%
D. 3个月Bcr-Abl > 10 %
【多选题】
ENESTnd 研究中,达希纳300mg BID组出现3-4级的胆固醇升高的人数为( )。删除
A. 0
B. 2
C. 3
D. 4
【多选题】
ENESTnd 研究中,随访到第5年时,达希纳300mgBID和伊马替尼治疗组的患者中,累积达到MMR的患者的百分比是多少?
A. 55%、27%
B. 62%、40%
C. 76%、56%
D. 77%、60%
【多选题】
ENESTnd的主要研究终点是( )。
A. 12个月时获得的MMR
B. 6个月时获得的MMR
C. 12个月时获得的CCyR
D. 12个月时获得的CCyR
【多选题】
ENESTnd试验核心研究中,有多少患者在第五年发生新的疾病进展?
A. 0
B. 1
C. 2
D. 3
【多选题】
ENESTnd研究landmark分析中,达希纳300mg BID治疗第六年哪组患者的结局百分率为94.5%?
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究landmark分析中,达希纳300mg BID治疗第五年哪组患者的结局百分率为97%?
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究随访五年时,以下哪个研究终点,达希纳300mg BID 和伊马替尼组之间反应差异率为23%?
A. MMR
B. MR4.0
C. MR4.5
D. MR5.0
【多选题】
ENESTnd研究中,达希纳300mgBID组中获得MR4.5的患者在60个月时发生疾病进展的人数为( )。
A. 1
B. 2
C. 0
D. 4
【多选题】
ENESTnd研究中,达希纳累积MR4.5率与伊马替尼相比的结果是( )。
A. 达希纳持续优于伊马替尼
B. 伊马替尼优于达希纳
C. 结果无差别
D. 以上均不正确
【多选题】
ENESTnd研究中,达希纳体现了良好的耐受性,48个月时达希纳300mg BID组患者的实际用药剂量达预期剂量的( )。
A. 0.8
B. 0.85
C. 0.9
D. 0.99
【多选题】
ENESTnd研究中,达希纳一线治疗6年累积达到MR4.5的患者比例为
A. 0.49
B. 0.52
C. 0.56
D. 0.58
【多选题】
ENESTnd研究中,达希纳与格列卫一线治疗6年累积达到MR4.5的患者比例的差值
A. 逐渐缩小
B. 逐渐增大
C. 基本不变
D. 先增大后缩小
【多选题】
ENESTnd研究中,达希纳组患者维持在慢性期的比例是( )。
A. 0.9
B. 0.85
C. 0.99
D. 0.8
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