【单选题】
- Excuse me, when will the 17:15 train arrive____
A. I don't tell you.
B. It's been delayed one hour.
C. You have to be patient.
D. Don't ask me.
查看试卷，进入试卷练习
微信扫一扫，开始刷题
相关试题
【单选题】
- Is John there?____
A. Speaking.
B. I'm not Mary.
C. Who are you?
D. Mary is well today.
【单选题】
- Would you like to join us for Sunday dinner____
A. It's nice of you to invite me.
B. How about the food?
C. I like onion soup.
D. I'm sorry I missed the fun last time.
【单选题】
- Could you tell me where the nearest parking lot is?____
A. Don't ask me.
B. Parking is very difficult.
C. Sorry, I'm a stranger here.
D. Sorry, you can't park here.
【单选题】
- Sorry, ___
A. here you are.
B. take it.
C. it's taken.
D. never mind.
【单选题】
－What's this in English? ____
A. It's a map.
B. That is a map.
C. Yes, it's a map.
D. No, it isn't.
【单选题】
- I hear you got through your exam. Congratulations!____
A. No. I didn't do well enough.
B. Who told you that?
C. Thanks.
D. Yes, I got a good mark.
【单选题】
- Don't forget to come to my party this evening!___
A. I can't.
B. I won't.
C. I don't.
D. I will.
【单选题】
- Jim, please don't put your head out of the window on the bus. It's dangerous!___
A. Good idea.
B. Sorry, I won't do it again.
C. It doesn't matter.
D. It's good.
【单选题】
-How about going fishing?___, I have no patience for that.
A. Excuse me
B. Sorry
C. Pardon
D. Apologize
【单选题】
- Thanks for the lovely and delicious food______.
A. No thanks
B. Never mind
C. All right
D. My pleasure
【单选题】
－ Haven't seen you for ages. Let's have a get-together next week._____
A. Great idea.
B. Welcome!
C. Yes, of course.
D. No, thanks.
【单选题】
- Do you mind if I switch off the radio? ______. Go ahead.
A. Never mind
B. No way
C. No, not at all
D. No, you'd better not
【单选题】
- Could I use your bike for a moment? ___
A. It's well.
B. It doesn't matter.
C. By all means.
D. I have no idea.
【单选题】
-How do you like the story?_______.
A. I'd like to read it
B. I like it very much
C. fine, thank you
D. It's very interesting
【单选题】
- I'll sorry to trouble you.______.
A. Don't say so
B. OK
C. It doesn't matter
D. That's fight
【单选题】
- We ordered 20 boxes of your products, but we have only got 19. - ____
A. You do not have to.
B. It does not matter.
C. We will send another tomorrow.
D. Nothing serious.
【单选题】
--Will you please give the note to him? _________.
A. Certainly, I'll give it to him
B. No, please not
C. Sorry, I don't
D. Yes, please do
【单选题】
- Thank you ever so much for your lovely gift____
A. Never mind
B. I'm glad you like it.
C. Please don't say so.
D. No, It's not so good.
【单选题】
- I'd like to invite you to dinner this Saturday, Mr. Smith.____
A. Oh, no. let's not.
B. I'd rather stay at home.
C. I'm sorry, but I have other plans.
D. Oh, no. That'll be too much trouble.
【单选题】
- Could you please open the window?____
A. I can't.
B. Go ahead.
C. Sure.
D. It's really very kind.
【单选题】
- Do you think I can borrow your bike for a few hours?____
A. I'm afraid you can.
B. I'm sorry, but I really need it this afternoon.
C. Yes, I don't think so.
D. I'll think about it later.
【单选题】
- Thank you very much for the dictionary you sent me.____
A. No thanks.
B. I'm glad you like it.
C. Please don't say so.
D. No, it's not so good.
【单选题】
- How do you like the movie we saw yesterday?____
A. You are welcome.
B. How about you?
C. I've never seen a better movie than it.
D. It is very expensive.
【单选题】
- What do you think of your new teacher____
A. He came to teach us last week.
B. He teaches us English.
C. He has two children.
D. He is very nice.
【单选题】
- Are you going to have a holiday?____
A. Not until next week.
B. Three weeks ago.
C. To Beijing.
D. I'm pleased to hear that.
【单选题】
- You seem to be lost. Need help? ____
A. Yes, would you please help me with the bag?
B. Help me find my key, please.
C. Yes, with pleasure.
D. I'm looking for Zhongshan Road.
【单选题】
- Can you help me clear up the mess____
A. Yes, it doesn't matter.
B. No, that's OK.
C. Yes, help yourself.
D. No problem.
【单选题】
- Does No.20 bus stop at our school?____
A. I go to school by bus.
B. I'm afraid not.
C. You are welcome.
D. I'll not take No.20 bus.
【单选题】
- Can I help you? ____
A. Sorry, I don't need your help.
B. What help can you give us?
C. I'd like to try on these shoes, please.
D. Thanks. You are welcome.
【单选题】
- Sorry to have kept you waiting. ____
A. That's OK.
B. What are you doing?
C. What's wrong with you?
D. Where have you been?
【单选题】
- What is she?____
A. She is a typist.
B. She is talking to her friend.
C. She is having a holiday.
D. She is my sister.
【单选题】
- That's a beautiful cat. I wonder who it belongs to.____
A. It belongs to the
B. rowns. B.The cat is my favourite too.
C. Mind your own business.
D. I can't say anything more.
【单选题】
- Excuse me, could you tell me the time____
A. You'd better buy a watch.
B. It's three thirty by my watch.
C. Can you see the clock?
D. It's late I think.
【单选题】
- What do you think of the movie we saw last night?____
A. The actress is bad.
B. Terrific!
C. The theatre is bad.
D. Nobody was there.
【单选题】
___ No, thanks. I'm just looking around. I'll let you know if I want anything.
A. Could you help me?
B. What will you buy?
C. Can I help you?
D. Do you like to look around?
【单选题】
- Hello, Peter. What do you do?____
A. I am fine.
B. I am not sick.
C. I am a student from Bonn University.
D. I came from Bonn University.
【单选题】
-Excuse me; can I have a seat here?___
A. Be hurry.
B. Come on.
C. Yes, please.
D. Do you mind?
【单选题】
- Shall we sit up here on the grass or down there near the water?___
A. I'd rather stay here if you don't mind.
B. Sorry, I don't like neither.
C. Certainly, why not？
D. Yes, we like these two places.
【单选题】
- What do you do on Sunday?___
A. I 'm a teacher.
B. I play football.
C. You are a student.
D. They clean rooms.
【单选题】
- Our class won the girls' relay race in our school's sports meeting.___
A. That's right.
B. Thanks a lot.
C. Congratulations!
D. It's a pleasure.
推荐试题
【多选题】
ENESTnd研究landmark分析中，达希纳300mg BID治疗第五年哪组患者的结局百分率为97%？
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究随访五年时，以下哪个研究终点，达希纳300mg BID 和伊马替尼组之间反应差异率为23%？
A. MMR
B. MR4.0
C. MR4.5
D. MR5.0
【多选题】
ENESTnd研究中，达希纳300mgBID组中获得MR4.5的患者在60个月时发生疾病进展的人数为（ )。
【多选题】
ENESTnd研究中，达希纳累积MR4.5率与伊马替尼相比的结果是（ ）。
A. 达希纳持续优于伊马替尼
B. 伊马替尼优于达希纳
C. 结果无差别
D. 以上均不正确
【多选题】
ENESTnd研究中，达希纳体现了良好的耐受性，48个月时达希纳300mg BID组患者的实际用药剂量达预期剂量的（ ）。
A. 0.8
B. 0.85
C. 0.9
D. 0.99
【多选题】
ENESTnd研究中，达希纳一线治疗6年累积达到MR4.5的患者比例为
A. 0.49
B. 0.52
C. 0.56
D. 0.58
【多选题】
ENESTnd研究中，达希纳与格列卫一线治疗6年累积达到MR4.5的患者比例的差值
A. 逐渐缩小
B. 逐渐增大
C. 基本不变
D. 先增大后缩小
【多选题】
ENESTnd研究中，达希纳组患者维持在慢性期的比例是（ ）。
A. 0.9
B. 0.85
C. 0.99
D. 0.8
【多选题】
ENESTnd研究中，达希纳组疾病进展（ ）伊马替尼组。
A. 低于
B. 高于
C. 等于
D. 以上均不正确
【多选题】
ENESTnd研究中，随访5年，达希纳一线治疗组疾病进展至AP/BC的患者数与伊马替尼相比，显著更少，分别为（ ）例和（ ）例。
A. 5，5
B. 6，7
C. 2，12
D. 8，9
【多选题】
ENESTnd研究中，伊马替尼治疗CML患者发生突变比达希纳治疗的患者多
A. 1.5倍
B. 2倍
C. 2.5倍
D. 3倍
【多选题】
"ENESTnd研究中，伊马替尼组MR4.5累积率不及达希纳治疗组，并且持续证实了MR4.5率比达希纳组更低的随访时间为
【多选题】
ENESTnd研究中，在发生突变的患者中，伊马替尼治疗出现治疗失败的患者数量为达希纳治疗的
A. 2倍
B. 2.5倍
C. 3倍
D. 4倍
【多选题】
ENESTnd研究中接受达希纳300 mg BID 治疗3个月时达到EMR的中度SOKAL风险患者的比例为
A. 0.89
B. 0.9
C. 0.91
D. 0.92
【多选题】
ENESTnd研究中接受达希纳治疗的患者在6年内未进展至AP/BC的比例为
A. 0.87
B. 0.61
C. 0.59
D. 0.99
【多选题】
ENESTop研究中，在符合严格的TFR尝试资格标准的患者中，停药144周后仍可保持TFR(无MMR丢失或MR4确认丢失)的患者比例为
A. 0.189
B. 0.237
C. 0.376
D. 0.484
【多选题】
ENESTop研究中MMR丢失或MR4确认丢失后重新启动后，每月监测一次，直到以前的MMR或MR4重新建立，此后监测时间为
A. 每4周一次
B. 每6周一次
C. 每12周一次
D. 每半年一次
【多选题】
ENESTswift 研究中大约三分之一的患者在因对伊马替尼或达沙替尼耐受不良而改用达希纳3个月后达到
A. 无MMR
B. MMR
C. MR4
D. MR4.5
【多选题】
ENESTxtnd研究中，一线达希纳300mg BID治疗反应欠佳或治疗失败后患者允许增加剂量至
A. 350 mg BID
B. 400 mg BID
C. 450 mg BID
D. 500 mg BID
【多选题】
ENESTxtnd研究中，一线达希纳治疗反应欠佳或治疗失败后增加剂量治疗后患者24个月内达到MMR的比例超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4的患者比例为
A. 0.54
B. 0.64
C. 0.73
D. 0.88
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者，（ ） 患者回复至慢性期。删除
A. 0.7
B. 0.85
C. 0.9
D. 0.96
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者，CHR持续率和CCyR持续率率可达（ ） 。
A. 0.56
B. 0.81
C. 56%和81%
D. 81%和56%
【多选题】
GIMEMA CML工作组数据，格列卫治疗CML-AP患者的7年OS达（ ）。
A. 0.43
B. 0.3
C. 0.23
D. 0.17
【多选题】
ICH是指（ ）。
A. 欧洲药品管理局
B. 国际协调会议
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
ICH指南推荐：如果药物有不同的晶型，应选择（ ） 的晶型。
A. 最多
B. 最常见
C. 热力学最稳定
D. 最易获得
【多选题】
IRIS研究中，伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
"PCR检测BCR-ABL mRNA转录，是灵敏度最高的检测方法，能在（ ） 细胞中检测出1个异常细胞。
A. 1000个
B. 1万个
C. 10万个
D. 100万个
【多选题】
Ph+CML的治疗和监测的发展主要是基于其特征性基因缺陷: （ ）。
A. Src
B. BCR-ABL
C. PDGFR
D. KIT
【多选题】
Ph+CML慢性期患者因换用α晶型仿制品而导致的生存期下降模型显示，格列卫换用α晶型仿制品治疗最差的情况下，患者质量调整生存年仅有（ ） 。
A. 13.44年
B. 1.8年
C. 9.57年
D. 5年
【多选题】
Ph+CML治疗中非常重要，是多数停药试验入组的必要条件。
A. 血液学反应
B. 细胞遗传学反应
C. 分子学反应
D. 更深的分子学反应（MR4.5）
【多选题】
RT-PCR能够在（ ）。
A. 20到25个细胞中检出1个白血病细胞
B. 200到500个细胞中检出1个白血病细胞
C. 2000到5000个细胞中检出1个白血病细胞
D. 10万到100万个细胞中检出1个白血病细胞
【多选题】
RT-Q-PCR非标准化是（ ）造成的。
A. 由于方法学和报告不同，导致结果各异
B. 每个患者的结果伴随一定程度的时间波动
C. 实验室间的结果比较不可行
D. 以上所有选项
【多选题】
Sokal评分是CML预后评估的一种方式，Sokal评分（ ）是高危患者？
A. Sokal评分<0.8
B. Sokal评分在0.8~1.2之间
C. Sokal评分>1.2
D. 以上均不正确
【多选题】
X-射线粉末衍射所示—α晶型和β晶型（ ）。
A. 存在差异
B. 不存在差异
C. 没有差异
D. 以上所有选项均错误
【多选题】
α晶型仿制品不仅稳定性差，还普遍存在（ ） 含量超标。
A. 遗传学毒性杂质
B. 活性成分
C. 选项1和2
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼（ ） 格列卫。
A. 就是
B. 不等于
C. 优于
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼处于（ ） ，可能向β晶型转变。
A. 高能态
B. 低能态
C. 稳定态
D. 以上所有选项均错误
