相关试题
【单选题】
— How are you, Bob?___
A. How are you?
B. I'm fine. Thank you.
C. How do you do?
D. Nice to meet you.
【单选题】
— Thanks for your help.___
A. My pleasure.
B. Never mind.
C. Quite right.
D. Don't thank me.
【单选题】
— Hello, my name is Charles Green, but ___ .
A. call my Charles
B. call me at
C. harles C. call me Charles
D. call Charles me
【单选题】
— ___, and how are you?
A. Don't mention it
B. Hm, not too bad
C. Thanks
D. Pretty fast
【单选题】
— I'm sorry. I am late due to the heavy traffic___
A. Well, it's OK.
B. No, it's all right.
C. You are welcome.
D. You are wrong.
【单选题】
— It's rather cold in here. Do you mind if I close the window?___
A. Yes, please.
B. No, please.
C. Sure, please.
D. I don't like it.
【单选题】
___He teaches physics in a school.
A. What does your father do?
B. Who is your father?
C. What is your father doing?
D. Where is your father now?
【单选题】
— Excuse me, how much is the jacket?___ It's 499 Yuan.
A. Oh, no. That's OK!
B. How do you like it?
C. Which do you prefer?
D. Would you like to try it on?
【单选题】
— Could you help me with my physics, please？___
A. No, no way.
B. No, I couldn't
C. No, I can't.
D. Sorry I can't. I have to go to a meeting right now.
【单选题】
— Could I speak to Don Watkins, please?___
A. Speaking, please.
B. Oh, how are you?
C. I'm listening.
D. I'm Don.
【单选题】
— Could I borrow your car for a few days?___
A. Yes, you may borrow.
B. Yes, go on.
C. Sure, here is the key. Enjoy your journey.
D. It doesn't matter.
【单选题】
— Thank you for inviting me.___
A. I really had a happy time.
B. Oh, it's too late.
C. Thank you for coming.
D. Oh, so slowly?
【单选题】
— May I see your tickets, please?___
A. Sure.
B. No, you can't.
C. No, they are mine.
D. Yes, you can.
【单选题】
— Please help yourself to the seafood.___
A. No, I can't.
B. Sorry, I can’t help.
C. Well, seafood don’t suit.
D. Well, I'm afraid I don't like seafood.
【单选题】
— Would you like to go to the concert with us this evening?___
A. No, I already have plans.
B. I'd love to, but I'm busy tonight
C. No, I really don't like being with you.
D. I'm ill, so I shouldn't go out.
【单选题】
— Congratulations! You won the first prize in today's speech contest.___
A. Yes, I beat the others.
B. No, no, I didn’t do it well.
C. Thank you.
D. It's a pleasure.
【单选题】
— Must I take a taxi? No, you___. You can take my car.
A. had better to
B. don't
C. must not
D. don't have to
【单选题】
— We are going to have a singing party tonight. Would you like to join us?___
A. I'm afraid not, because I have to go to an important meeting.
B. Of course not. I have no idea
C. No, I can’t.
D. That's all set
【单选题】
— How was your trip to London, Jane?___
A. Oh, wonderful indeed.
B. I went there alone.
C. The guide showed me the way.
D. By plane and by bus.
【单选题】
— Hey, Tom, what's up?___
A. Yes, definitely!
B. Oh, not much.
C. What is happening in your life?
D. You are lucky.
【单选题】
— Do you mind my smoking here?___
A. No, thanks.
B. Yes, I do.
C. Yes. I'd rather not.
D. Good idea.
【单选题】
— Did you know that David injured his leg yesterday?Really? ___
A. Who did that?
B. What's wrong with him?
C. How did that happen?
D. Why was he so careless?
【单选题】
— This box is too heavy for me to carry it upstairs.___
A. You may ask for help.
B. I'll give you a hand.
C. Please do me a favor.
D. I'd come to help.
【单选题】
— I wonder if I could use your computer tonight?___ I'm not using it right now.
A. Sure, here you are.
B. I don't know.
C. It doesn't matter.
D. Who cares?
【单选题】
— Excuse me, could you show me the way to the nearest post office?___ Oh yes! Two blocks away from here at the Green Avenue. You can’t miss it.
A. I beg your pardon?
B. What do you mean?
C. You’re welcome.
D. Um, let me think.
【单选题】
— Wow! This is a marvelous room! I’ve never known you’re so artistic.____
A. Great, I am very art-conscious.
B. Don’t mention it.
C. Thanks for your compliments.
D. It's fine.
【单选题】
— Is it possible for you to work late tonight？___
A. I like it.
B. I'll do that.
C. I'd love to. .
D. I think so.
【单选题】
— Unbelievable! I have failed the driving test again!___ This is not the end of the world.
A. Good luck.
B.
C. heer up. C. Go ahead.
D. No problem.
【单选题】
Are you feeling better today, Jack?___
A. There must be something wrong.
B. Just have a good rest.
C. Yes, thank you, doctor. But I still don't feel good.
D. Don’t worry about me.
【单选题】
Thank you so much for your lovely gift.___
A. Never mind.
B. I'm glad you like it.
C. Please don't say so.
D. No, It's not so good.
【单选题】
Would you like something to drink? What about a cup of tea?___
A. No, thanks.
B. No, I wouldn’t
C. Yes, I want.
D. Yes, I like.
【单选题】
What's the problem with your bike?___
A. Not at all.
B. Good, thank you.
C. Nothing serious.
D. Sure.
【单选题】
Good morning, John. How are you doing?___
A. I'm pleased
B. Good night.
C. Not so bad. And you?
D. How do you do?
【单选题】
How do you do?___
A. Fine, thank you.
B. How do you do?
C. Not too bad.
D. Very well.
【单选题】
Good-bye for now.___
A. The same to you.
B. That's OK
C. See you.
D. Long time no see.
【单选题】
Hello, how are you?___
A. Hello, how are you?
B. How do you do?
C. Fine, thank you.
D. That's OK.
【单选题】
I didn't mean to do that. Please forgive me。___
A. Not too bad.
B. That's all right
C. It's a pleasure.
D. Thank you.
【单选题】
Thank you for your invitation.___
A. It doesn’t matter.
B. It's a pleasure.
C. It's a small thing.
D. I'll appreciate it.
【单选题】
What a beautiful dress you have on today!___
A. It is suitable for me.
B. No, it isn’t.
C. You want to have one, too?
D. Thank you.
【单选题】
I think he is a good lecturer.___
A. Sorry, it doesn’t matter.
B. So do I.
C. Yes. It's a good idea
D. I don't mind
推荐试题
【多选题】
达希纳能够抑制（ ）激酶的自磷酸化。
A. Bcr-Abl（20-60nM）
B. PDGFR（69nM）
C. Src
D. c-Kit（210nM）
【多选题】
达希纳胶囊服用时，可以咀嚼或吮吸，可以打开胶囊。
【多选题】
达希纳含有乳糖，所以对于（ ）的患者，不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳服用时，如果错过给药，患者不得另外补充剂量，而是按照处方服用下一次剂量。
【多选题】
伴有（ ）的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
TKI治疗均的CV风险管理中，属于可更改的因素有（ ）。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
【多选题】
TKI治疗均的CV风险管理中，属于不可更改的因素有（ ）。
【多选题】
ENESTnd研究中的分组有（ ）。
A. 达希纳300mg BID
B. 达希纳400mg BID
C. 伊马替尼400mg QD
D. 伊马替尼400mg BID
【多选题】
ENESTnd研究中，在5年随访中，所有时间点达希纳组MMR的比例始终高于伊马替尼组。
【多选题】
ENESTnd研究中，与伊马替尼相比，达希纳一线治疗组疾病进展至AP/BC显著更少。
【多选题】
ENESTnd研究中，排除（ ）类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
ENESTnd研究中，从第一年至第五年的随访中，达希纳和伊马替尼组累积的MR4.5相差的比例保持完全不变。
【多选题】
ENESTnd标志性分析中，3个月时获得BCR-ABLIS≤10%与60个月时更佳的OS无关
【多选题】
在TIDEL-II研究中，服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在ENESTnd研究中，在伊马替尼400mg每天治疗失败后将剂量增加至600或800 mg每天不会导致超过一半的患者反应改善。
【多选题】
在ENESTnd研究所有风险组中，伊马替尼治疗的EMR失败率比达希纳高3-4倍。
【多选题】
在ENESTnd或DASISION研究中，5年随访时，伊马替尼二线治疗组获得MR4.5的中位时间均未达到。
【多选题】
"与竞品达沙替尼相比，达希纳精准强效抑制BCR-ABL
【多选题】
与竞品达沙替尼相比，达希纳非血液学不良反应交叉不耐受发生率高？
【多选题】
以下关于DASISION研究的描述，正确的是（ ）。
A. DASISION试验的研究终点是CCyR，而不是MMR
B. DASISION试验中，达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中，达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
IRIS研究中，伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
IRIS研究随访10年, 32% 伊马替尼治疗患者由于不满意治疗反应中断治疗，＞10%由于不良事件。
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENESTnd研究中在伊马替尼治疗12个月内的MMR率为27%。
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
DASISON 研究中，达沙替尼胸腔积液的复发率是（ ）。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
DASISION研究的终点是（ ）。
A. 6个月内，证实获得的CCyR
B. 12个月内，证实获得的CCyR
C. 6个月内，证实获得的MMR
D. 12个月内，证实获得的MMR
【多选题】
DASISION 研究4年随访中，22%的达沙替尼治疗患者中经常报告的不良事件是（）。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
ENESTFreedom研究中，重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
在研究2101中，换用达希纳400 mg BID后大多数获得反应的患者达到 Ph+ < 35%的时间为
A. 1个月内
B. 3个月内
C. 6个月内
D. 12个月内
【多选题】
在格列卫治疗出现的33种突变中，达希纳能够有效抑制其中种突变？
A. 15种突变
B. 20种突变
C. 32种突变
D. 33种突变
【多选题】
在服用达希纳最初的2个月，由于骨髓抑制，应每隔（ ）做一次全血细胞计数，之后可每（ ）检测一次，或者在有临床指征时进行。
A. 2周，1个月
B. 1周，2个月
C. 3周，1个月
D. 2周，2个月
【多选题】
在服药前至少4小时以及服药后至少4小时内不能进食？
【多选题】
在二代TKI选择时，可以参照BCR-ABL激酶域突变类型选择药物，如患者是F317L/V/I/C、V299L、T315A突变采用（ ）治疗更易获得临床疗效？
A. 达希纳
B. 施达赛
C. 以上均正确
D. 以上均不正确
【多选题】
在NOVEL研究中，因AEs中断伊马替尼治疗的患者在换用达希纳后AEs缓解的比例为
A. 0.6
B. 0.72
C. 0.79
D. 0.84
【多选题】
在ENESTop研究TFR过程中使用的监测要求为如果MMR丢失或MR4确认丢失(连续测量2次，间隔4周，显示MR4丢失)，达希纳重新启动于
A. 2周内
B. 4周内
C. 3个月内
D. 1年内
【多选题】
在ENESTnd研究中接受伊马替尼治疗3个月的高度SOKAL风险患 者未达到EMR比例超过
A. 0.56
B. 0.44
C. 0.3
D. 0.21
