【单选题】
I hope that you'll be more careful in typing the letter. Don't _________ anything.___
A. lack
B. withdraw
C. omit
D. leak
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相关试题
【单选题】
The tomato juice left brown __________ on the front of my jacket.___
A. spot
B. point
C. track
D. trace
【单选题】
The committee is totally opposed ________ any changes being made in the plans.___
A. of
B. on
C. to
D. against
【单选题】
I'm very sorry to have _______ you with so many questions on such an occasion.___
A. interfered
B. offended
C. impressed
D. bothered
【单选题】
The price of beer _______ from 50 cents to $4 per liter during the summer season.___
A. altered
B. ranged
C. separated
D. differed
【单选题】
Their son doesn't know what to ________ at the university; he can't make up his mind about his future.___
A. take in
B. take up
C. take over
D. take after
【单选题】
Although they plant trees in this area every year, the tops of some hills are still _________.___
A. blank
B. hollow
C. vacant
D. bare
【单选题】
Being a pop star can be quite a hard life, with a lot of traveling ________ heavy schedules.
A. with regard to
B. as to
C. in relation to
D. owing to
【单选题】
Tony is very disappointed _______ the results of the exam.
A. with
B. for
C. toward
D. on
【单选题】
William Penn, the founder of Pennsylvania, _________ defended the right of every citizen to freedom of choice in religion.
A. peculiarly
B. indifferently
C. vigorously
D. inevitably
【单选题】
When people become unemployed, it is _______ which is often worse than lack of wages.___
A. laziness
B. poverty
C. idleness
D. inability
【单选题】
In previous times, then fresh meat was in short __________, pigeons were kept by many households as a source of food.
A. store
B. provision
C. reserve
D. supply
【单选题】
Those gifts of rare books that were given to us were deeply _________.___
A. appreciated
B. approved
C. appealed
D. applied
【单选题】
It is our ___________ policy that we will achieve unity through peaceful means.___
A. consistent
B. continuous
C. considerate
D. continual
【单选题】
He is __________ about his chances of winning a gold medal in the Olympics next year.___
A. optimistic
B. optional
C. outstanding
D. obvious
【单选题】
The director was critical _______________ the way we were doing the work.___
A. at
B. in
C. of
D. with
【单选题】
In a sudden _____________ of anger, the man tore up everything within reach.___
A. attack
B. burst
C. split
D. blast
【单选题】
In Britain people _____________ four million tons of potatoes every year.___
A. swallow
B. dispose
C. consume
D. exhaust
【单选题】
I'd _____________ his reputation with other farmers and business people in the community, and then make a decision about whether or not to approve a loan.___
A. take into account
B. account for
C. make up for
D. make out
【单选题】
She cooked the meat for a long time so as to make it _____________ enough to eat.___
A. mild
B. slight
C. light
D. tender
【单选题】
The computer revolution may well change society as _____________ as did the Industrial Revolution.___
A. certainly
B. insignificantly
C. fundamentally
D. comparatively
【单选题】
A lot of ants are always invading my kitchen. They are a thorough ___________.___
A. nuisance
B. trouble
C. worry
D. anxiety
【单选题】
As we can no longer wait for the delivery of our order, we have to _________ it.___
A. postpone
B. refuse
C. delay
D. cancel
【单选题】
When a fire _________ at the National Exhibition in London, at least ten priceless paintings were completely destroyed.___
A. broke of
B. broke out
C. broke down
D. broke up
【单选题】
The destruction of these treasures was a loss for mankind that no amount of money could __________.___
A. stand up to
B. make up for
C. come up with
D. put up with
【单选题】
The student was just about to ___________ the questions, when suddenly he found the answer.___
A. arrive at
B. submit to
C. work out
D. give up
【单选题】
When there are small children around, it is necessary to put bottles of pills out of _________.___
A. reach
B. hand
C. hold
D. place
【单选题】
The _________ of blood always makes him feel sick.___
A. sight
B. view
C. look
D. form
【单选题】
In Britain, the best season of the year is probably __________ spring.___
A. later
B. last
C. latter
D. late
【单选题】
Free medical treatment in this country covers sickness of mind as well as _________ sickness.___
A. normal
B. regular
C. average
D. ordinary
【单选题】
Although he had looked through all the reference material on the subject, he still found it hard to understand this point and her explanation only _________ to his confusion.___
A. extended
B. amounted
C. added
D. turned
【单选题】
A completely new situation will ___________ when the examination system comes into existence.___
A. arise
B. rise
C. raise
D. arouse
【单选题】
Cancer is second only __________ heart disease as a cause of death.___
A. of
B. to
C. with
D. from
【单选题】
The manager needs an assistant that he can _________ to take care of problems in his absence.___
A. count on
B. count in
C. count up
D. count out
【单选题】
We gave out a cheer when the red roof of the cottage came __________ view.___
A. from
B. in
C. before
D. into
【单选题】
They took ________ measures to prevent poisonous gases from escaping.___
A. fruitful
B. beneficial
C. valid
D. effective
【单选题】
Doing your homework is a sure way to improve your test scores, and this is especially true _______ it comes to classroom tests.___
A. when
B. since
C. before
D. after
【单选题】
In developing countries people are _______ into overcrowded cities in great numbers.___
A. breaking
B. filling
C. pouring
D. hurrying
【单选题】
There are other problems which I don't propose to ____________ at the moment.___
A. go into
B. go around
C. go for
D. go up
【单选题】
It is quite necessary for a qualified teacher to have good manners and _________ knowledge.___
A. extensive
B. expansive
C. intensive
D. expensive
【单选题】
I'm not sure whether I can gain any profit from the investment, so I can't make a(n) ______ promise to help you.___
A. exact
B. defined
C. definite
D. sure
推荐试题
【多选题】
2017 ESMO定义的TKI治疗3个月达最佳反应标准为
A. "≥ PCyR (Ph+ ≤ 35%) ,BCR-ABL < 10% "
B. "Ph+ 36%-95% ,BCR-ABL > 10% "
C. "CCyR (Ph+ 0) , BCR-ABL < 1% "
D. "Ph+ 1%-65% ,BCR-ABL 1%-10% "
【多选题】
2017 ESMO推荐CML治疗3个月BCR-ABLIS > 10% 达治疗警告时,应对患者
A. 筛查更密切,患者有可能的话换用其他药物治疗
B. 筛查更密切,每月一次
C. 换用其他TKI治疗,继续原TKI治疗或增加伊马替尼剂量为下一步 HCT进行评估
D. 以上都不对
【多选题】
AP和BC分别是指( )。
A. 慢性期和加速期
B. 加速期和急变期
C. 慢性期和急变期
D. 加速期和慢性期
【多选题】
CML患者疾病进展后,中位生存时间不足
A. 2年
B. 6个月
C. 1年
D. 1年3个月
【多选题】
CML预后分析Sokal积分公式中包含( )等预后因素。
A. 年龄、脾脏大小、血小板、原始细胞
B. 年龄、脾脏大小、血小板、嗜酸性细胞百分数
C. 年龄、脾脏大小、血小板、嗜碱性细胞百分数
D. 以上所有选项均错误
【多选题】
CML诊断标准包括( )。
A. 典型的临床表现
B. 有Ph染色体
C. 有BCR-ABL融合基因阳性
D. 典型的临床表现,有Ph染色体和/或有BCR-ABL融合基因阳性
【多选题】
CML治疗的首要目标是使患者维持在( )。
A. 加速期
B. 慢性期
C. 急变期
D. 以上均不正确
【多选题】
CML治疗反应的监测方法包括( )?
A. "全血细胞计数
B. 骨髓细胞遗传学分析
C. 实时定量聚合酶链反应检测(RQ-PCR)
D. 以上均正确
【多选题】
DASISION 研究4年随访中,22%的达沙替尼治疗患者中经常报告的不良事件是()。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
DASISION研究的终点是( )。
A. 6个月内,证实获得的CCyR
B. 12个月内,证实获得的CCyR
C. 6个月内,证实获得的MMR
D. 12个月内,证实获得的MMR
【多选题】
DASISON 研究中,达沙替尼胸腔积液的复发率是( )。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
ELN推荐,获得MMR的患者,应每( )进行常规IS RQ-PCR监测。
A. 3-6个月
B. 6-12个月
C. 8-10个月
D. 1-2个月
【多选题】
ELN推荐,治疗12个月时的最佳疗效反应为( )。
A. BCR-ABL≤10%和/或CCyR( 0%到35%,Ph+ 染色体)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐,治疗3个月时的最佳疗效反应为( )。
A. BCR-ABLIS≤10%和/或PCyR(0%到35%,Ph+中期分裂)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐,治疗6个月时的最佳疗效反应为( )。
A. BCR-ABL≤10%和/或PCyR(0%到35%,Ph+ 中期分裂)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐患者应该进行常规IS RQ-PCR监测,每( )个月一次,直至获得MMR。
【多选题】
EMA 2006年颁布指南:每天摄入遗传毒性杂质应( )。
A. ≤1.5微克
B. =1.5微克
C. >1.5微克
D. 以上所有选项均错误
【多选题】
EMA是指( ) 。
A. 欧洲药品管理局
B. 欧洲白血病网
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
ENESTchina的主要研究终点是( )。
A. 12个月的MMR,定义为BCR-ABL≤0.1%
B. 6个月的MMR,定义为BCR-ABL≤0.1%
C. 24个月的MMR,定义为BCR-ABL≤0.1%
D. 36个月的MMR,定义为BCR-ABL≤0.1%
【多选题】
ENESTchina中,中国CML 发病的中位年龄是( )。
【多选题】
ENESTcmr研究中,与使用伊马替尼相比, 使用达希纳实现首次MR4.5的中位时间缩短了
A. 3个月
B. 6个月
C. 1年
D. 2年
【多选题】
ENESTFreedom研究中,巩固期PCR检测频率为
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
ENESTFreedom研究中,停药后48周维持TFR的患者比例为
A. 0.442
B. 0.516
C. 0.589
D. 0.56
【多选题】
ENESTFreedom研究中,重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
ENESTFreedom研究中,重启治疗的标准是
A. 丧失MR4.5
B. 丧失MMR
C. 丧失CCyR
D. 疾病进展
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENESTnd 研究随访到5年时,达希纳300mgBID和伊马替尼组的患者中,达到MR4.5的患者的百分比是多少?
A. 32%、15%
B. 40%、 23%
C. 42%、 24%
D. 54%、 31%
【多选题】
ENESTnd 研究中,达希纳300mg BID 和伊马替尼组患者在12个月时累计的MMR率是多少?
A. 40% 和 23%
B. 54% 和 31%
C. 60% 和 31%
D. 55% 和 27%
【多选题】
ENESTnd 研究中,达希纳300mg BID 和伊马替尼组患者在三个月没有达到BCR-ABL ≤ 10%的百分比是多少?
A. 7% 和 29%
B. 7% 和 30%
C. 9% 和 30%
D. 9% 和 33%
【多选题】
ENESTnd 研究中,达希纳300mg BID 和伊马替尼组患者在以下哪个milstone的百分比分别为91%和 67%?
A. 6个月Bcr-Abl ≤ 1%
B. 6个月Bcr-Abl > 1%
C. 3个月Bcr-Abl ≤ 10%
D. 3个月Bcr-Abl > 10 %
【多选题】
ENESTnd 研究中,达希纳300mg BID组出现3-4级的胆固醇升高的人数为( )。删除
【多选题】
ENESTnd 研究中,随访到第5年时,达希纳300mgBID和伊马替尼治疗组的患者中,累积达到MMR的患者的百分比是多少?
A. 55%、27%
B. 62%、40%
C. 76%、56%
D. 77%、60%
【多选题】
ENESTnd的主要研究终点是( )。
A. 12个月时获得的MMR
B. 6个月时获得的MMR
C. 12个月时获得的CCyR
D. 12个月时获得的CCyR
【多选题】
ENESTnd试验核心研究中,有多少患者在第五年发生新的疾病进展?
【多选题】
ENESTnd研究landmark分析中,达希纳300mg BID治疗第六年哪组患者的结局百分率为94.5%?
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究landmark分析中,达希纳300mg BID治疗第五年哪组患者的结局百分率为97%?
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究随访五年时,以下哪个研究终点,达希纳300mg BID 和伊马替尼组之间反应差异率为23%?
A. MMR
B. MR4.0
C. MR4.5
D. MR5.0
【多选题】
ENESTnd研究中,达希纳300mgBID组中获得MR4.5的患者在60个月时发生疾病进展的人数为( )。
【多选题】
ENESTnd研究中,达希纳累积MR4.5率与伊马替尼相比的结果是( )。
A. 达希纳持续优于伊马替尼
B. 伊马替尼优于达希纳
C. 结果无差别
D. 以上均不正确
【多选题】
ENESTnd研究中,达希纳体现了良好的耐受性,48个月时达希纳300mg BID组患者的实际用药剂量达预期剂量的( )。
A. 0.8
B. 0.85
C. 0.9
D. 0.99