相关试题
【多选题】
DASISION 研究4年随访中，22%的达沙替尼治疗患者中经常报告的不良事件是（）。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
ENESTFreedom研究中，重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
下列哪项是ENESTFreedom研究入组标准
A. 成人CML-CP
B. b2a2和/或b3a2转录
C. 筛查期的MMR>2年
D. ≥2年一线尼洛替尼
【多选题】
在研究2101中，换用达希纳400 mg BID后大多数获得反应的患者达到 Ph+ < 35%的时间为
A. 1个月内
B. 3个月内
C. 6个月内
D. 12个月内
【多选题】
在格列卫治疗出现的33种突变中，达希纳能够有效抑制其中种突变？
A. 15种突变
B. 20种突变
C. 32种突变
D. 33种突变
【多选题】
在服用达希纳最初的2个月，由于骨髓抑制，应每隔（ ）做一次全血细胞计数，之后可每（ ）检测一次，或者在有临床指征时进行。
A. 2周，1个月
B. 1周，2个月
C. 3周，1个月
D. 2周，2个月
【多选题】
在服药前至少4小时以及服药后至少4小时内不能进食？
【多选题】
在二代TKI选择时，可以参照BCR-ABL激酶域突变类型选择药物，如患者是F317L/V/I/C、V299L、T315A突变采用（ ）治疗更易获得临床疗效？
A. 达希纳
B. 施达赛
C. 以上均正确
D. 以上均不正确
【多选题】
在NOVEL研究中，因AEs中断伊马替尼治疗的患者在换用达希纳后AEs缓解的比例为
A. 0.6
B. 0.72
C. 0.79
D. 0.84
【多选题】
在ENESTop研究TFR过程中使用的监测要求为如果MMR丢失或MR4确认丢失(连续测量2次，间隔4周，显示MR4丢失)，达希纳重新启动于
A. 2周内
B. 4周内
C. 3个月内
D. 1年内
【多选题】
在ENESTnd研究中接受伊马替尼治疗3个月的高度SOKAL风险患 者未达到EMR比例超过
A. 0.56
B. 0.44
C. 0.3
D. 0.21
【多选题】
"在ENESTnd研究中接受伊马替尼核心治疗反应欠佳/治疗失败的患者换用达希纳400 mg BID后患者达到CCyR和MMR的比例分别为
A. 0.58
B. 0.6
C. 0.32
D. 0.42
【多选题】
在ENESTnd研究中，伊马替尼治疗组疾病进展至AP/BC的患者是达希纳治疗组的
【多选题】
在ENESTnd研究中，无论SOKAL风险如何，伊马替尼治疗的CML患者12个月时未达到MMR的比例超过
A. 0.4
B. 0.5
C. 0.6
D. 0.7
【多选题】
在ENESTnd研究中, 达希纳组实现MR4.5的中位时间 > 2年较伊马替尼快。
【多选题】
在ENESTnd研究随访6年时，CML患者死亡最常见的原因为
A. 晚期CML
B. 疾病进展
C. 肺炎
D. 心血管事件
【多选题】
在ENEST1st研究中接受达希纳治疗的患者中，超过五分之一12个月内达到 MR4.5 ，在24个月内比例几乎翻倍，约39达到MR4.5。
【多选题】
在ENEST1st研究中，接受达希纳治疗的患者在3个月时达到EMR的比例为
A. 0.93
B. 0.95
C. 0.97
D. 0.99
【多选题】
在2101研究中，CML患者换用达希纳后48个月时PFS估计率为
A. 0.5
B. 0.57
C. 0.6
D. 0.63
【多选题】
应用达希纳期间，可能出现QT间期延长，在（ ）检查ECG监测QT间期？
A. 开始给药前
B. 给药后7天
C. 以及有临床指征时
D. 以上所有选项
【多选题】
以下哪个不是达希纳常见的不良反应？
A. 皮疹
B. 胆红素增高
C. 胸腔积液
D. 骨髓抑制
【多选题】
以下哪个不是ENESTnd试验的排除标准？
A. 临床显著的心动过缓（<50次/分钟 ）
B. 近期发生过心肌梗死
C. 不稳定性心绞痛病史（过去12个月中 ）
D. 可控制的糖尿病
【多选题】
依据Cmax/IC50结果显示，达希纳在体内抑制肿瘤细胞的活性是伊马替尼的（ ）倍？
A. 26.3倍
B. 16.3倍
C. 6.3倍
D. 3倍
【多选题】
相对伊马替尼，达希纳更容易与ABL结构域紧密结合?
【多选题】
相比格列卫，达希纳一线治疗的哪项优势与TFR相关
A. Earlier，更早的分子学反应
B. Deeper，更深的分子学反应
C. Fewer，更少的疾病进展风险
D. 以上均不正确
【多选题】
下列哪项是达希纳一线停药研究
A. Nilo post-STIM
B. ENESTop
C. ENESTFreedom
D. ENESTPath
【多选题】
下列哪项是达希纳停药研究巩固期可能出现的不良事件
A. 骨骼肌肉痛
B. 胰腺炎
C. 皮疹
D. 心血管事件
【多选题】
下列哪项是达希纳停药研究TFR期可能出现的不良事件
A. 骨骼肌肉痛
B. 体液潴留
C. 皮疹
D. 心血管事件
【多选题】
下列哪项是ENESTFreedom研究TFR期的PCR检测频率
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
下列哪项不是达希纳一线注册研究ENESTnd的分组
A. 尼洛替尼400mg,QD
B. 尼洛替尼300mg,BID
C. 尼洛替尼400mg,BID
D. 伊马替尼400mg,QD
【多选题】
所有TKI治疗均需要CV风险管理，以下哪项属于可更改的因素？
【多选题】
如果心电图显示QTc>（ ）毫秒，则应暂停服用达希纳。
A. 400
B. 480
C. 450
D. 500
【多选题】
如果心电图显示QTc> 480毫秒，则应停止服用达希纳，及时纠正低钾或低镁，并必须检查合并用药的情况。
【多选题】
哪项是达希纳靶向作用于酪氨酸激酶的正确顺序
A. Bcr-Abl>PDGFR/c-KIT
B. PDGFR/c-KIT>Bcr-Abl
C. Src>Bcr-Abl
D. Bcr-Abl>Src
【多选题】
患者服用达希纳时，如果出现有显著临床意义的中度或严重的非血液学毒性，应如何处理（ ）?
A. 中止治疗；毒性缓解后，恢复每日一次，每次400mg的剂量。
B. 中止治疗，不再使用
C. 继续治疗，观察一段时间
D. 继续治疗，没有影响
【多选题】
关于ENESTnd和ENESTchina 研究，以下哪个说法是错误的？
A. ENESTnd是3臂试验，ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTchina中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
根据ELN指南，（ ）属于治疗失败？
A. 3个月时Bcr-Abl >10%
B. 6个月时没有达到CCyR
C. 12个月时没有达到MMR
D. 在任何时间失去曾经获得的CCyR
【多选题】
服用达希纳时，应避免与CYP3A4强抑制剂同时使用，比如（ ）?
A. 酮康唑
B. 伊曲康唑
C. 克拉霉素
D. 以上均正确
【多选题】
费城染色体阳性（Ph+）的CML细胞需要活化的Bcr-Abl信号才能存活，因此当达希纳阻断了Bcr-Abl融合蛋白的激活后，CML的发生与进展的关键步骤即被抑制？
【多选题】
对于转氨酶超过正常值2.5倍或胆红素升高超过正常值1.5倍的肝损害患者，不推荐使用达希纳？
推荐试题
【多选题】
Which two are true about the Risk badge in vRealize Operations? (Choose two.)___
A. The Risk badge indicates potential future problems that may degrade the performance of the system.
B. Risks may require attention in the near future.
C. The Risk badge indicates problems that are degrading performance of the system.
D. Risks require attention now to correct system performance problems.
【多选题】
vSphere Update Manager allows which two virtual machine attributes to be upgraded? (Choose two.)___
A. Virtual machine firewall policies for NSX.
B. Software Packages in the virtual machine.
C. Virtual machine Hardware Version.
D. VMware Tools Upgrade.
【多选题】
What are two benefits of using NFS 4.1 with vSphere 6.x as compared to NFS 3? (Choose two.)___
A. NFS 4.1 supports Kerberos Authentication
B. NFS 4.1 supports multipathing
C. NFS 4.1 supports IPv6
D. NFS 4.1 supports hardware acceleration
【多选题】
Which three statements are true regarding Fault Tolerance? (Choose three.)___
A. Applications need to be continuously available to users.
B. Applications without native clustering capabilities can be protected.
C. Custom clustering solutions are complicated to configure and maintain.
D. Applications that have 16 vCPUs are supported.
E. Prevents application crashes by analyzing the workload and correcting problems.
【多选题】
Which two statements are true regarding VMware vSphere Flash Read Cache (vFRC)? (Choose two.)___
A. Cache fills and cache evictions happen in the granularity of a cache block size.
B. vFRC caches data from both read and write I/Os, but write I/Os are always serviced by the underlying storage.
C. vFRC caches data from both read and write I/Os, but write I/Os are always serviced by the underlying cache data.
D. Cache fills and cache evictions happen in the granularity of the disk block size.
【多选题】
What are two possible causes of Storage Distributed Resource Scheduler (SDRS) being disabled on one or more virtual machine disks in a datastore cluster? (Choose two.)___
A. The virtual machine has vSphere Fault Tolerance disabled.
B. The virtual machine is a template.
C. The virtual machine swap file is on a shared datastore.
D. The disk is a CD-ROM/ISO file.
【多选题】
An administrator attempts to install vCenter Single Sign-On Server. The installer returns an error message indicating that the installation failed. Prior to the installation, all setup prerequisites were met. The administrator has generated a vCenter Server Single Sign-On support bundle. Which two files should the administrator analyze to determine the cause of the failure? (Choose two.)___
A. Server\utils\logs\imsTrace.log
B. Server\utils\logs\install.txt
C. %TEMP%\utils\logs\vminst.log
D. %TEMP%\vminst.log
【多选题】
An administrator is unable to remove an ESXi 6.x host from a vSphere Distributed Switch. What are two likely reasons for this issue? (Choose two.)___
A. Vmkernel interfaces on the switch are still in use.
B. VM Network port group adapters are connected to different switch.
C. Physical NICs are migrated to different switch.
D. VM Network adapters are connected to this switch.
【多选题】
Which two Identity Sources are available to add for vCenter Single Sign-On authentication? (Choose two.)___
A. LocalOS
B. OpenLDAP
C. NIS as an LDAP Server
D. VCMSDS
【多选题】
What are three goals of resource management within a cluster? (Choose three.)___
A. To prevent virtual machines from monopolizing resources and to guarantee predictable service rates.
B. To exploit undercommitted resources and overcommit with graceful degradation.
C. To provide solutions to potential problems that you might encounter when using vCenter Server.
D. To control the relative importance of virtual machines and provide flexible dynamic partitioning.
E. To provide additional network administration capabilities.
【多选题】
Which three actions can be taken as a result of executing the vSphere Update Manager 6.x scan and remediation wizards? (Choose three.)___
A. Install and upgrade software in virtual machines.
B. Upgrade the firmware on ESXi host devices.
C. Upgrade and Patch ESXi hosts.
D. Install and update third-party software on hosts.
E. Upgrade virtual machine hardware.
【多选题】
Which two statements are true about deploying and using vSphere Replication? (Choose two.)___
A. ESXi hosts managed by a single vCenter Server instance require a connection between the two vSphere Replication appliances.
B. Sites managed by different vCenter Server instances require a connection between the two vSphere Replication appliances.
C. Sites managed by different vCenter Server instances require the use of Site Recovery Manager and a connection between the two vSphere Replication appliances.
D. ESXi hosts managed by a single vCenter Server instance require a single vSphere Replication appliance.
【多选题】
An administrator is attempting to power on a virtual machine, but the task is hanging at 95%. What three scenarios best explain why this problem is happening? (Choose three.)___
A. A virtual machine question is currently being posed to the administrator.
B. Another task for the virtual machine or other component is already in progress.
C. The VMware High Availability cluster has insufficient resources to guarantee failover.
D. The host has lost access to the storage device containing the virtual machine files.
E. The host is under resource contention and unable to power on the virtual machine.
【多选题】
Which three features are not supported when using Fault Tolerance in vSphere 6.x? (Choose three.)___
A. Virtual Volumes (VVOLS)
B. Storage vMotion
C. Virtual Machine Component Protection
D. vMotion
E. vSphere Distributed Switches
【多选题】
Which two storage controller configurations can be used with Virtual SAN? (Choose two.)___
A. SAS controllers in Passthrough mode
B. SAS controllers in RAID0 mode
C. SAS controllers in RAID1 mode
D. SAS controllers in RAID10 mode
【多选题】
Which three are requirements when using vMotion to move a virtual machine across vCenter Server systems? (Choose three.)___
A. Both vCenter Servers must be using Enhanced Linked Mode.
B. Both vCenter Servers must be in the same Single Sign-On Domain.
C. Time must be synchronized.
D. Duplicate VM MAC addresses must be configured.
E. Both vCenter Servers must have High Availability enabled on source and destination clusters.
【多选题】
Which two components can be used when configuring Enhanced Linked Mode? (Choose two.)___
A. vCenter Server Appliance
B. vRealize Operations Manager
C. vSphere Management Appliance
D. vCenter Server for Windows
【多选题】
An organization has a number of virtual machines that would benefit from Fault Tolerance. These include: <A single vCPU Apache Server> < A dual vCPU vCenter Server> < A quad vCPU SQL Server> <An eight vCPU Hadoop Server>. Which two virtual machines can be configured to use VMware Fault Tolerance? (Choose two.)___
A. Apache Server
B. vCenter Server
C. SQL Server
D. Hadoop Server
【多选题】
Which two badges are major badges in vRealize Operations? (Choose two.)___
A. Risk
B. Efficency
C. Workload
D. Faults
【多选题】
An administrator is deploying multiple Windows 2003 Virtual Machines from the same template. What two steps should be taken to avoid network conflicts? (Choose two.)___
A. Customize the guest operating system.
B. Install VMware Tools into the new virtual machines.
C. Copy the Microsoft Sysprep tools onto the vCenter Server system.
D. Ensure the e1000 vmnic is selected for each new virtual machine.
【多选题】
Which three conditions would prevent Storage I/O Control from being enabled on a group of datastores? (Choose three.)___
A. The datastores planned for the solution are used by different vSphere clusters.
B. A datastore planned for the solution is configured as a Raw Device Mapping file.
C. A datastore planned for the solution has three extents.
D. A datastore planned for the solution is configured as NFS.
E. The organization has an Enterprise license.
【多选题】
Which two actions are prerequisites to adding ESXi 6.x hosts to a vSphere Distributed Switch? (Choose two.)___
A. Verify that there is at least one Distributed Port Group on the Distributed Switch.
B. Verify that the Distributed Port Group have active uplinks configured in its teaming and failover policy.
C. Verify that the
D. istributed Switch has been configured with a Network Profile.
【多选题】
An organization has configured Distributed Power Management (DPM) on a vSphere 6 cluster. The organization wants to be alerted when an ESXi host has been powered down by DPM. Which two options represent the type and name of the alarm that would accomplish this? (Choose two.)___
A. DrsEnteringStandbyModeEvent
B. DrsEnteredStandbyModeEvent
C. Event-based
D. Condition-based
【多选题】
Which two allow for the disabling of Network Rollback operations? (Choose two.)___
A. Modifying the vpxd advanded configuration options and adding the config.vpxd.network.rollback key
B. Modifying the C:\ProgramData\VMware\CIS\cfg\vmware-vpx\vpxd.cfg file and adjusting the<rollback> xml tag
C. Modifying the C:\ProgramData\VMware\CIS\cfg\vmware-vpx\vpxd.cfg file and adjusting the <networkrollback> xml tag
D. Modifying the C:\ProgramData\VMware\CIS\cfg\vmware-vpx\firstboot\vpxd-service- spec.prop file and adjusting the <rollback> xml tag
【多选题】
An administrator is tasked with performing a vMotion migration of a virtual machine. The virtual machine is configured as follows: <vSphere Flash Read Cache (vFRC) enabled> <Is part of a Distributed Resource Cluster (DRS) Cluster> Which two statements are true? (Choose two.)___
A. Each ESXi host in the cluster supports multiple virtual flash resources.
B. Each ESXi host in the cluster supports one virtual flash resource.
C. DRS treats powered-on virtual machines with Flash Read Cache as having a preferred affinity to their current host and moves them only for mandatory reasons.
D. DRS treats powered-on virtual machines with Flash Read Cache as having a required affinity to their current host and does not move them.
【多选题】
An administrator is using the Host Failures to Tolerate Admission Control Policy for a vSphere High Availability ___ cluster. When configuring this setting on the cluster, the administrator sees this error message: <Insufficient resources to satisfy HA failover level on cluster > What are two likely causes for the error? (Choose two.)(AB)
A. The hosts in the cluster are disconnected.
B. A host in the cluster is displaying an HA error.
C.
D. istributed Resource Scheduler has not been configured on the cluster.
【多选题】
What are two ways to identify TCP/IP stack information? (Choose two.)___
A. Using the vSphere Web Client
B. Using esxcli network ip netstack
C. Using esxcfg-netstack
D. Using the vSphere Client
【多选题】
Which two actions are required when enabling vFlash Read Cache for a virtual machine's virtual disk? (Choose two.)___
A. A value in the Virtual Flash Read Cache text box must be entered.
B. A Flash Resource Pool for Cache size reservation must be entered.
C. The Device backing and the block size must be configured.
D. The
E. nable virtual flash host swap cache check box must be selected.
【多选题】
What two IT infrastructure components are virtualized by vSphere Essentials? (Choose two.)___
A. Networks
B. Applications
C. Storage
D. Management
【多选题】
When attempting to access a virtual machine, an administrator is unable to login using the vSphere credentials. What two options are probable causes of the authentication failure? (Choose two.)___
A. The vSphere credentials have not been granted permissions.
B. The vSphere credentials are granted read-only permissions.
C. The vSphere credentials are granted no-access permissions.
D. The vSphere credentials are not a member of the local administrator group.
【多选题】
An administrator is performing a scripted installation of ESXi 6.x. In which three locations does the script need to be? (Choose three.)___
A. PXE Server
B. HTTPS
C. FTP
D. NFS
E. VVOLs Datastore
【多选题】
In order for a company to meet regulatory requirements, all ESXi 6.x Hosts must be configured to direct logs to a syslog server. What are two ways ESXi hosts can configured for this action? (Choose two)___
A. Use the esxcli system syslog command.
B. Edit them in the ESXi host Advanced System Settings.
C. From the Syslog collector user interface of the Web Client.
D. Syslog logging is not available for
E. SXi Hosts.
【多选题】
Which three actions can be executed when an alarm is triggered? (Choose three.)___
A. Send an email.
B. Send an SNMP trap.
C. Run a script or command.
D. Run an Orchestrator workflow.
E. Send a trigger to syslog.
【多选题】
An administrator is attempting to power on a virtual machine, but is unable to do so. Which two reasons are probable causes of the failure? (Choose two.)___
A. Storage access to the virtual machine swap file has been lost.
B. One of the virtual machine VMDK files is locked.
C. Virtual machine is running CentOS 7.0 64-bit.
D. Virtual machine has Hyper-Threading enabled.
【多选题】
An administrator has configured a host profile so that ESXi 6.x hosts will point to the corporate NTP server for time synchronization. The NTP server is located at 10.0.30.213, but time has not been synchronized properly across the ESXi hosts. The administrator reviews Host Profile settings as shown in the Exhibit. Which two steps are required to resolve the issue? (Choose two.)___
A. Correct the NTP server IP address.
B. Check the host for host profile compliance.
C. Remediate the host based on the updated host profile.
D. Change the NTP server to the FQDN as IP Addresses are not supported.
【多选题】
An administrator is attempting to migrate a large Hadoop virtual machine using vMotion. The administrator notices a delay when the machine is quiesced. The Hadoop virtual machine is processing many transactions a second to an in-memory database. Which two actions would help reduce the amount of time needed to perform a vMotion on this virtual machine? (Choose two.)___
A. Use multiple NICs for the vMotion vmkernel port.
B. Use a 10Gbps Network card for the vMotion vmkernel port.
C. Add an additional management network to help transmit the data quicker.
D. Disable Fault Tolerance before performing the vMotion.
【多选题】
An administrator is installing a new network card in an ESXi 6.x host that is part of a vSphere cluster. When the host is placed into maintenance mode, the vSphere Web Client displays the progress bar at 2% for over 30 minutes. Which two are likely reasons for this occurrence? (Choose two.)___
A. Maintenance mode is unable to migrate all virtual machines from the host.
B. There is a large number of virtual machines that must be migrated from the host.
C. VMware High Availability is in the process of reconfiguring the cluster.
D. Each virtual machine on the
E. SXi host must be reconfigured to recognize the new adapter.
【多选题】
Which two events happen when Distributed Resource Scheduler (DRS) is disabled? (Choose two.)___
A. The cluster's resource pool heirarchy and affinity rules are re-established when DRS is turned back on.
B. The cluster's resource pool hierarchy and affinity rules are not re-established when DRS is turned back on.
C. The cluster's resource pools are removed from the cluster.
D. The cluster's resource pools are removed from the cluster and assigned to the hosts.
【多选题】
Which two networking connection types can be configured on a virtual switch? (Choose two.)___
A. Virtual machine portgroups
B. VMkernel services (such as NFS, iSCSI, or vMotion) to the physical network
C. Web services over the Management Network
D. NFS and FCoE storage services
【多选题】
An administrator creates a DRS cluster of eight ESXi 6.x hosts. There are 10 virtual machines balanced across the hosts. An attempt to place the first host into maintenance mode fails. What are two reasons that the host failed to enter maintenance mode? (Choose two.)___
A. The DRS cluster Automation Level is set to Partially Automated mode.
B. One of the virtual machines on the ESXi Host entering maintenance mode is configured with a DRS Host affinity rule Should run on hosts in group.
C. One of the virtual machines on the ESXi Host entering maintenance mode is configured with a DRS Host affinity rule Must run on hosts in group.
D. One of the virtual machines on the
E. SXi Host entering maintenance mode is configured with an individual Automation Level set to Partially Automated.
