【多选题】
关于艾曲泊帕的剂量初始和调整方案，说法错误的是?
A. 初始剂量：25mg/d，为了获得≥50 x 109/L的血小板计数，最高可调整为75mg
B. 至少2周治疗后血小板 <50 x 109/L，以25mg的量增加每日剂量，最高至75mg
C. "血小板 ≥50 x 109/L~≤150 x 109/L，使用最低剂量的艾曲泊帕和/或同时进行ITP治
D. 血小板>150 x 109/L，停止使用艾曲泊帕。增加血小板监测的频率到每周两次
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相关试题
【多选题】
艾曲泊帕的服用方法，错误的是?
A. 食用影响艾曲泊帕吸收的药物前2小时或4小时后再服药
B. 早餐服药宜选择：凌晨6点-上午9点
C. 晚餐服药宜选择：下午3点-晚上9点
D. 口服，每天一次
【多选题】
会影响艾曲泊帕的吸收的食物或药物，不包括?
A. 乳制品或富含钙的食物
B. 抗酸药
C. 一些矿物质和维生素添加剂
D. 富含脂肪的食物
【多选题】
瑞弗兰的目标患者群是？
A. 既往放化疗有血小板减少症史，拟再次接受放化疗的患者
B. 一线糖皮质激素治疗失败或复发的慢性免疫性血小板减少症患者
C. 脾切除及至少一种免疫抑制剂治疗无效的慢性ITP患者
D. 新诊断ITP患者一线联合治疗
【多选题】
以下哪个药物不是临床常见的ITP二线治疗药物？
A. 环孢素
B. 特比奥
C. 甲强龙
D. 硫唑嘌呤
【多选题】
瑞弗兰可用于治疗？（中国适应症）
A. 糖皮质激素、免疫球蛋白或脾切除疗效不佳的成人及12岁及以上慢性免疫性血小板减少症（ITP）患者
B. 需要初始和维持干扰素治疗的慢性丙肝合并血小板减少症的患者
C. 糖皮质激素、免疫球蛋白或脾切除疗效不佳的1岁及以上儿童慢性免疫性血小板减少症（ITP）患者
D. 免疫抑制治疗疗效不佳的重度再生障碍性贫血患者
【多选题】
瑞弗兰的推广口号是？
A. 快速升板，方便安全
B. 快速升板，安全方便
C. 瑞享人生，弗兰相伴
D. 快速升板，方便安心
【多选题】
下列选项不是瑞弗兰核心推广策略的是？
A. 使现有TPO制剂使用者优先选择瑞弗兰
B. 与被视为“治愈”的现有二线治疗方案进行品牌区隔
C. 从新定义ITP一线激素治疗疗效评价标准，明确何时应启动二线治疗
D. 与一线糖皮质激素联合使用，提升新诊断ITP患者的治疗效果
【多选题】
瑞弗兰的核心推广信息有？
A. 首个也是唯一获得批准的口服小分子非肽TPO受体激动剂
B. 与TPO受体的跨膜区选择性的相互作用，不会与内源性TPO竞争，不会诱导TPO抗体
C. 大规模临床研究显示瑞弗兰能快速有效提高ITP患者的血小板水平，且安全性良好，不良反应可控
D. 以上都是
【多选题】
在全球范围内，瑞弗兰已批准的适应症可以治疗如下患者，除了？
A. 新诊断的免疫性血小板减少症患者
B. 新诊断的重型再生障碍性贫血患者
C. 丙肝应用干扰素治疗导致血小板较少症的患者
D. 大于1岁的慢性免疫性血小板减少症儿童患者二线治疗
【多选题】
以下说法错误的是？
A. 瑞弗兰需要终身服药
B. 瑞弗兰是TPO受体激动剂
C. 瑞弗兰不会诱导TPO抗体产生
D. 瑞弗兰与特比奥作用位点不同
【多选题】
ITP的治疗目标不包含？
A. 提升患者血小板至安全水平
B. 尽可能减少临床出血事件
C. 改善患者的生活质量
D. 尽可能减少治疗花费
【多选题】
艾曲波帕的半衰期是12–21 小时(血浆)？
【多选题】
艾曲波帕的结合位点与TPO的结合位点不同，因此与内源性TPO可能产生协同效应？
【多选题】
EXTEND研究中，52%的患者减少伴随用药剂量？
【多选题】
EXTEND研究中安全性结果与早期研究报道相一致，在长达8.76年的随访过程未发现新的安全性问题？
【多选题】
东亚ITP受试者血浆中艾曲波帕药时曲线下面积(AUC)和峰值浓度(Cmax)分别比白种人高1.85和1.6倍？
【多选题】
国研究中，艾曲波帕初始剂量为25mg/日，如果血小板疗效(>50 ×109/L)未达到，每2周按25mg/日的剂量增加，直至达最大值75mg/日？
【多选题】
RAISE研究中，血小板计数高于400x10^9/L时应中断艾曲泊帕治疗，待低于150 x 10^9/L时以更低剂量恢复治疗？
【多选题】
RAISE研究中，艾曲泊帕组出现疗效反应的几率是安慰剂组的8.2倍？
【多选题】
RAISE研究中，治疗两周直至治疗结束期间，艾曲泊帕组患者中位血小板计数维持在50 x 10^9/L以上？
【多选题】
利妥昔单抗：40%患者治疗无效，起效较慢？
【多选题】
利妥昔单抗有两种用法，其中大剂量为1000mg，静脉滴注，用2次，间隔14天？
【多选题】
重组人血小板生成素(rh-TPO) 可用于治疗实体瘤化疗后所致的血小板减少症，适用对象为血小板低于100×10^9/L且医生认为有必要升高血小板治疗的患者？
【多选题】
国外早期曾研发过重组人非全长型TPO，单检测到rh-TPO抗体的产生，对内源性TPO具有交叉免疫作用，中和其生物学活性？
【多选题】
艾曲泊帕与TPO的结合位点不同，因此不会与内源性TPO竞争？
【多选题】
EXTEND研究中，基线时血小板计数≥50,000/µL患者不接受伴随药物治疗？
【多选题】
EXTEND研究中，8.76年随访中获得高治疗反应,艾曲泊帕治疗中85.8%患者至少获得一次治疗反应？
【多选题】
中国研究中，首次达到血小板计数>50×109/L中位时间是6.12周？
【多选题】
" RAISE 研究中，艾曲泊帕组 79%患者至少出现一次治疗反应 (vs 28% 安慰机组;
【多选题】
RAISE研究中，艾曲泊帕较安慰剂显著降低出血，出血降低与生活质量的改善相关？
【多选题】
艾曲泊帕一日一次，服用方便，亚洲人的初始剂量为25mg？
【多选题】
当血小板>150 x 109/L ~ ≤250 x 109/L时，停止使用艾曲泊帕。增加血小板监测的频率到每周两次？
【多选题】
对于肝损伤的患者，初始计量必须为25mg，每日一次，而且在至少3周内不要改变剂量？
【多选题】
"艾曲泊帕治疗慢性ITP患者2周快速起效，可显著提升ITP患者血小板计数水平，并显
【多选题】
艾曲泊帕口服给药，可减少患者其他伴随或补救药物的使用，降低治疗相关不良事件，对患者的生活质量无影响？
【多选题】
对于成人慢性ITP患者，艾曲波帕减少患者对伴随用药和挽救性治疗的需求？
【多选题】
RAISE研究中，入选ITP患者的病程超过6个月？
【多选题】
艾曲波帕是一种口服、小分子、非肽类的TPO受体激动剂，能够减少血小板的生成？
【多选题】
RAISE研究中，入选ITP患者的病程超过6个月？
【多选题】
RAISE研究中，艾曲泊帕治疗第一周，中位血小板计数增加两倍(从16 x 109/L 增加为~36 x 109/L)？
推荐试题
【单选题】
Of the following writers, is NOT included in the group of naturalists.
A. A. Stephen Crane
B. B. Frank Norris
C. C. Theodore Dreiser
D. D. Herman Melville
【单选题】
Of the following, is NOT characteristic of Mark Twain’s works.
A. A. colloquial speech
B. B. a sense of humor
C. C. a realistic view
D. D. an idealistic view
【单选题】
Of the following, is considered Herman Melville’s masterpiece.
A. A. The Last of the Mohicans
B. B. The Legend of Sleepy Hollow
C. C. Moby Dick
D. D. Daisy Miller
【单选题】
Of the following, is NOT Nathaniel Hawthorne’s work.
A. A. The Scarlet Letter
B. B. The House of the Seven Gables
C. C. The Marble Faun
D. D. Nature
【单选题】
is regarded as “the father of American literature”.
A. A. James Fennimore Cooper
B. B. Ralph Waldo
C. C. Thomas Jefferson
D. D. Washington Irving
【单选题】
Of the following writers, are from the Colonial and Revolutionary Periods.
A. A. Benjamin Franklin & Edgar Ellen Poe
B. B. Edgar Ellen Poe & Jonathan Edwards
C. C. Benjamin Franklin & Jonathan Edwards
D. D. Edgar Ellen Poe & Washington Irving
【单选题】
The National Day of the United States falls on .
A. A. June 4th
B. B. July 4th
C. C. June 14th
D. D. July 14th
【单选题】
Of the following, is NOT among the three major radio and TV networks in America.
A. A. the National Broadcasting System (NBS)
B. B. the Public Broadcasting Service (PBS)
C. C. the Columbia Broadcasting System (CBS)
D. D. the American Broadcasting System (ABS)
【单选题】
is sold especially to the upper or upper-middle class and it has a reputation for its serious attitude and great bulk.
A. A. The Washington Post
B. B. The New York Times
C. C. Los Angeles Times
D. D. New York Daily News
【单选题】
Of the following universities, has NOT cultivated any American President yet.
A. A. Harvard University
B. B. Massachusetts Institute of Technology
C. C. Princeton University
D. D. Yale University
【单选题】
To get a bachelor’s degree, all undergraduate students are required to do the following except .
A. A. attending lectures and completing assignments
B. B. passing examinations
C. C. working for communities
D. D. earning a certain number of credits
【单选题】
Of the following, is NOT the responsibility of the board of trustees in U. S. institutions.
A. A. choosing the president
B. B. establishing policies for administrators and faculty
C. C. approving budget and other financial project
D. D. decide which student to enroll
【单选题】
Of the following, are NOT among the categories of American higher education.
A. A. universities and colleges
B. B. research institutions
C. C. technical institutions
D. D. community colleges
【单选题】
Higher education in the United States began with the founding of
A. A. Yale University
B. B. Harvard University
C. C. Princeton University
D. D. New York University
【单选题】
Of the following subjects, are NOT offered to elementary school students.
A. A. mathematics and languages
B. B. politics and business education
C. C. science and social studies
D. D. music and physical education
【单选题】
Formal education in the United States consists of , secondary and higher education.
A. A. kindergarten
B. B. public
C. C. elementary
D. D. private
【单选题】
At present, U. S. exports account for of the world’s total.
A. A. 10%
B. B. 15%
C. C. 20%
D. D. 25%
【单选题】
is not one of the three giants in American automobile industry.
A. A. Ford
B. B. General Motors
C. C. Chrysler
D. D. American Motors
【单选题】
The following statements are all true except .
A. A. Agribusinesses reflect the big, corporate nature of many farm enterprises.
B. B. Agribusinesses maintain a balanced trade pattern between agricultural imports and exports.
C. C. Agribusinesses range from one-family corporations to multinational firms.
D. D. Agribusinesses include a variety of farm businesses and structures.
【单选题】
About of American crops are for export.
A. A. half
B. B. one third
C. C. one fourth
D. D. one fifth
【单选题】
President Johnson tried to build a “Great Society” by introducing various programs like the following except .
A. A. Medicare
B. B. Food Stamps
C. C. Education Initiatives
D. D. Unemployment Pension
【单选题】
The following inventions took place during the “second indThe following inventions took place during the “second industrial revolution” except .
A. A. typewriter
B. B. telephone
C. C. electric light
D. D. refrigerator
【单选题】
The first National Bank of the United States was established with the urge of .
A. A. George Washington
B. B. Thomas Jefferson
C. C. Andrew Jackson
D. D. Alexander Hamilton
【单选题】
Chartered companies were NOT granted the by the British King or Queen.
A. A. political authority
B. B. economic rights
C. C. judicial authority
D. D. diplomatic authority
【单选题】
The modern American economy progressed from to , and eventually, to .
A. A. colonial economy, handcraft economy, industrial economy
B. B. farming economy, handcraft economy, industrial economy
C. C. colonial economy, farming economy, industrial economy
D. D. handcraft economy, farming economy, industrial economy
【单选题】
America produces a major portion of the world’s products in the following fields except .
A. A. machinery
B. B. automobiles
C. C. ore
D. D. chemicals
【单选题】
The President is directly voted into office by .
A. A. all citizens of America
B. B. the citizens over 18 years old
C. C. electors elected by the voters
D. D. the senators and representatives
【单选题】
The Supreme Court is composed of justices.
A. A. six
B. B. seven
C. C. eight
D. D. nine
【单选题】
The terms for a Senator and Representative are and years respectively.
A. A. two, four
B. B. two, three
C. C. two, six
D. D. six, two
【单选题】
According to the Constitution, a candidate for President must be .
A. A. at least 35 years old
B. B. at least a 14 years’ resident of the United States
C. C. born in America
D. D. all of the above
【单选题】
The following except are all powers of the President.
A. A. vetoing any bills passed by Congress
B. B. appointing federal judges when vacancies occur
C. C. making laws
D. D. issuing executive orders
【单选题】
All the following except cannot make legislative proposal.
A. A. the Senator
B. B. the Representative
C. C. the Secretary of State
D. D. the President
【单选题】
The following except are guaranteed in the Bill of Rights.
A. A. freedom of religion
B. B. the right to get into people’s house by police
C. C. freedom of speech and of press
D. D. the right to own one’s weapon if one wishes
【单选题】
The Bill of Rights .
A. A. defines the rights of Congress and the rights of the President
B. B. guarantees citizens of the United States specific individual rights and freedoms
C. C. is part of the Declaration of Independence
D. D. has no relationship with the Constitution
【单选题】
The Constitution of the United States .
A. A. gives the most power to Congress
B. B. gives the most power to the President
C. C. tries to give each branch enough power to balance the others
D. D. gives the most power to the Supreme Court
【单选题】
The U. S. Constitution came into effect in .
A. A. 1787
B. B. 1789
C. C. 1791
D. D. 1793
【单选题】
The Vietnam War was a long-time suffering for Americans, and it continued throughout the terms of Presidents .
A. A. Johnson, Nixon and Ford
B. B. Truman, Eisenhower and Kennedy
C. C. Kennedy, Johnson and Nixon
D. D. Eisenhower, Kennedy and Johnson
【单选题】
President applied New Deal to deal with the problems of the Great Depression.
A. A. Wilson
B. B. Truman
C. C. Roosevelt
D. D. Kennedy
【单选题】
The policy of the United States was at the beginning of the two world wars.
A. A. neutrality
B. B. full involvement
C. C. partial involvement
D. D. appeasement
【单选题】
Abraham Lincoln issued to grant freedom to all slaves.
A. A. Declaration of Independence
B. B. Constitution
C. C. Emancipation Proclamation
D. D. Bill of Rights
