【多选题】
使用Sokal评分对CML患者进行风险分组，（ ）为中危组。
A. <0.8
B. 0.8-1.2
C. >1.2
D. 以上所有选项均错误
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相关试题
【多选题】
所有TKI治疗均需要CV风险管理，以下哪项属于可更改的因素？
【多选题】
体细胞突变可致（ ） ，导致癌肿形成。
A. 胎儿畸形
B. 成年动物细胞的不正常分裂
C. 成年动物细胞的不正常增生
D. 以上所有选项
【多选题】
通过温度和湿度变化，水可以是（ ） 的。
A. 气态
B. 液态
C. 固态
D. 以上所有选项
【多选题】
下列哪项不是达希纳一线注册研究ENESTnd的分组
A. 尼洛替尼400mg,QD
B. 尼洛替尼300mg,BID
C. 尼洛替尼400mg,BID
D. 伊马替尼400mg,QD
【多选题】
下列哪项是达希纳一线停药研究
A. Nilo post-STIM
B. ENESTop
C. ENESTFreedom
D. ENESTPath
【多选题】
相同分子的物质呈现不同晶型结构时，（ ） 。
A. 存在差异
B. 不存在差异
C. 差异未知
D. 以上所有选项均错误
【多选题】
药物多晶型可影响（ ） 等特性。
A. 可溶性，溶解度
B. 生物活性和生物等效性
C. 吸水性、颗粒形状、密度、流动性和致密性
D. 以上所有选项
【多选题】
伊马替尼结晶前为（ ） 。
A. 伊马替尼游离碱
B. 伊马替尼α晶型
C. 伊马替尼β晶型
D. 以上所有选项
【多选题】
伊马替尼由于在很多临床研究中证实其很高的血液学、细胞遗传学、分子学缓解率以及很好的安全性被广泛接受作为CML的（ ）治疗。
A. 一线标准
B. 二线标准
C. 三线标准
D. 四线标准
【多选题】
依据Cmax/IC50结果显示，达希纳在体内抑制肿瘤细胞的活性是伊马替尼的（ ）倍？
A. 26.3倍
B. 16.3倍
C. 6.3倍
D. 3倍
【多选题】
遗传毒性是指（ ） 。
A. 对生物体遗传物质（染色体）所产生的毒性
B. 对生物体造成的可遗传的毒性
C. 对生物体造成的生殖毒性
D. 对生物体生育力造成的毒性
【多选题】
以下哪个不是ENESTnd试验的排除标准？
A. 临床显著的心动过缓（<50次/分钟 ）
B. 近期发生过心肌梗死
C. 不稳定性心绞痛病史（过去12个月中 ）
D. 可控制的糖尿病
【多选题】
以下哪个不是达希纳常见的不良反应？
A. 皮疹
B. 胆红素增高
C. 胸腔积液
D. 骨髓抑制
【多选题】
以下哪个生化异常会增加心脑血管事件发生？
A. 胆红素和脂类升高
B. 血糖和脂类降低
C. 血糖和脂类升高
D. 胆红素和血糖降低
【多选题】
以下哪个是心脑血管疾病不可改变的危险因素？
A. 高血压
B. 性别
C. 糖尿病
D. 吸烟
【多选题】
以下哪个是心脑血管疾病的可改变的危险因素？
A. 糖尿病
B. 性别
C. 年龄
D. 家族史
【多选题】
应用达希纳期间，可能出现QT间期延长，在（ ）检查ECG监测QT间期？
A. 开始给药前
B. 给药后7天
C. 以及有临床指征时
D. 以上所有选项
【多选题】
有研究表明，格列卫换用α晶型仿制品治疗，（ ） 明显更低。
A. 无进展生存期
B. 总生存期
C. 质量调整生存年
D. 以上所有选项
【多选题】
有研究表明，格列卫换用α晶型伊马替尼治疗，患者（ ） 。
A. 疾病进展
B. 疗效丧失
C. 不良反应严重
D. 以上所有选项
【多选题】
有研究表明，格列卫换用α晶型伊马替尼治疗3个月，17%的患者快速进展至（ ）。
A. 慢性期
B. 加速期
C. 急变期
D. 选项2和3
【多选题】
有研究表明，格列卫一线治疗CML-BC患者长期生存率（ ）。
A. 高
B. 低
C. 未知
D. 以上所有选项均错误
【多选题】
有研究表明，格列卫治疗CML-BC患者，（ ） 患者回复至慢性期。
A. 0.75
B. 0.68
C. 0.55
D. 0.5
【多选题】
越早获得（ ）意味着获得（ ）机会越大?
A. MMR，CMR
B. CMR，CMR
C. MMR，MMR
D. CMR，MMR
【多选题】
在2101研究中，CML患者换用达希纳后48个月时PFS估计率为
A. 0.5
B. 0.57
C. 0.6
D. 0.63
【多选题】
在ENEST1st研究中，接受达希纳治疗的患者在3个月时达到EMR的比例为
A. 0.93
B. 0.95
C. 0.97
D. 0.99
【多选题】
在ENESTnd研究随访5年时，在接受达希纳300 mg BID治疗的患者中感染发生率低于
A. 0.05
B. 0.1
C. 0.15
D. 0.2
【多选题】
在ENESTnd研究中，无论SOKAL风险如何，伊马替尼治疗的CML患者12个月时未达到MMR的比例超过
A. 0.4
B. 0.5
C. 0.6
D. 0.7
【多选题】
在ENESTnd研究中，伊马替尼治疗组疾病进展至AP/BC的患者是达希纳治疗组的
【多选题】
在ENESTnd研究中接受伊马替尼治疗3个月的高度SOKAL风险患 者未达到EMR比例超过
A. 0.56
B. 0.44
C. 0.3
D. 0.21
【多选题】
在ENESTop研究TFR过程中使用的监测要求为如果MMR丢失或MR4确认丢失(连续测量2次，间隔4周，显示MR4丢失)，达希纳重新启动于
A. 2周内
B. 4周内
C. 3个月内
D. 1年内
【多选题】
在NOVEL研究中，因AEs中断伊马替尼治疗的患者在换用达希纳后AEs缓解的比例为
A. 0.6
B. 0.72
C. 0.79
D. 0.84
【多选题】
在二代TKI选择时，可以参照BCR-ABL激酶域突变类型选择药物，如患者是F317L/V/I/C、V299L、T315A突变采用（ ）治疗更易获得临床疗效？
A. 达希纳
B. 施达赛
C. 以上均正确
D. 以上均不正确
【多选题】
在服用达希纳最初的2个月，由于骨髓抑制，应每隔（ ）做一次全血细胞计数，之后可每（ ）检测一次，或者在有临床指征时进行。
A. 2周，1个月
B. 1周，2个月
C. 3周，1个月
D. 2周，2个月
【多选题】
在格列卫治疗出现的33种突变中，达希纳能够有效抑制其中种突变？
A. 15种突变
B. 20种突变
C. 32种突变
D. 33种突变
【多选题】
在既往TKI研究中，DASISION研究应用（ ） 进行风险评分。
A. sokal
B. Hasford
C. EUTOS
D. SAPS
【多选题】
在既往TKI研究中，ENEST1st研究应用（ ）进行风险评分。
A. sokal
B. Hasford
C. EUTOS
D. SAPS
【多选题】
在既往TKI研究中，IRIS、ENESTnd等研究都应用（ ）进行风险评分。
A. sokal
B. Hasford
C. EUTOS
D. SAPS
【多选题】
在研究2101中，换用达希纳400 mg BID后大多数获得反应的患者达到 Ph+ < 35%的时间为
A. 1个月内
B. 3个月内
C. 6个月内
D. 12个月内
【多选题】
早期分子学反应，意味着随后获得的MMR率会（ ）。
A. 更高
B. 更低
C. 无影响
D. 不确定
【多选题】
早期分子学反应，意味着随后获得深层分子学（MR4.5）率会（ ）。
A. 更高
B. 更低
C. 无影响
D. 不确定
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___ the world has ever seen has occurred in the information and communications technologies.
A. Great a change
B. The great change
C. A greatest change
D. The greatest change
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___ so many people around, it wasn’t convenient to have a long talk with him.
A. As
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Alice used to be terribly shy, but working abroad for a year has completely ___ her.
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The adoption of this measure will greatly reduce the ___ of greenhouse gas emissions (排放物), which may help slow global warming.
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I think I have a healthy lifestyle. I eat a lot of fruit and vegetables, and I’m a ___ drinker.
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If a person simply does not care about this activity, it’s ___ impossible to get him to participate.
A. barely
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Sometimes, even when the mind ___ functioning, the body keeps on working normally.
A. ceases
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Jeffery expressed his ___ about the health and fitness of his co-workers, but they said they didn’t want to “waste time” on an exercise bike or jogging.
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Such chemicals are indeed negatively ___ those humans to whom they are expose D.
A. risking
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We regret for selling you the faulty product, and our company has agreed to ___ you by $500.
A. match
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This lecture taught me how to manage my time better to include my online studies in my busy ___.
A. schedule
B. outline
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Generally speaking, an Irish person will not accept an offer straight away; he will ___ once or twice first before accepting it.
A. receive
B. decline
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There is every possibility that many species (物种) of animals will die out because of their disappearing food ___.
A. mode
B. source
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As a college student, you should enjoy learning and get yourself ___ in those things that interest you.
A. concerned
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The name of Hitler (希特勒) has always been associated with war and ___ killing in the minds of those people who lived through World War Two.
A. imaginary
B. multiple
C. indispensable
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【单选题】
He works hard every day to make more money, but he ___ his health, time with his family, and the hobbies he once love D.
A. neglects
B. reminds
C. ceases
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【单选题】
I asked a passenger sitting beside me if our train was the Westlake Express train, and he said he ___ of it.
A. not even heard
B. had not even heard
C. even not heard
D. ever had not heard
【单选题】
Whatever you say in the paper has to ___ your own thinking; hence simply repeating the professor’s opinions or whatever is in the readings will not get you very far.
A. ignore
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【单选题】
We are sorry to know that they did not succeed ___ the project for lack of necessary funds.
A. to fulfill
B. to have fulfilled
C. in fulfilling
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【单选题】
It is surprising that fewer students were prepared to undertake the ___ to hand in written work on a regular basis, or to study over long periods.
A. engagement
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C. authority
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【单选题】
Emily felt hurt and ___ by a close friend who had borrowed a considerable sum of money to pay for a house and then took it as a gift, never thinking of giving back the money.
A. conflicted
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【单选题】
In 1988 the old system was ___ in the country and a new system was introduced to take effect in 1990.
A. transmitted
B. abolished
C. assumed
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【单选题】
We should not ___ ourselves to the classroom. We should go out of the classroom, see the world and talk to others as much as we can.
A. entertain
B. confine
C. assign
D. involve
【单选题】
I have always been grateful ___ Fred __the generous and helpful information when I was at the crossroads.
A. to … for
B. to … with
C. for … with
D. for … to
【单选题】
I think we both need to ___ the past, be happy about what we had for a time, learn from our experiences, and move on from there.
A. let go of
B. give authority to
C. make sense of
D. keep up with
【单选题】
My brother and I managed to ___ with each other and we soon made peace after a week’s quarrel.
A. heal
B. reconcile
C. respond
D. advocate
【单选题】
The two robbers in a stolen car tried to ___ a police roadblock (路障), but faile D.
A. break in
B. break off
C. break up
D. break through
【单选题】
Because of his long illness, Lee’s English level had dropped, but he was determined to ___ the other students by working harder.
A. put up with
B. catch up with
C. get along with
D. fill up with
【单选题】
We appreciate your efforts in making changes in your schedule and think that this new arrangement is now ___ to us.
A. agreeable
B. sustainable
C. portable
D. indispensable
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The woman who died in a car crash last Saturday in the suburbs has been ___ as Kate Johnson, a 25-year-old office clerk.
A. justified
B. identified
C. notified
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【单选题】
My nephew failed in the College Entrance Examination, and we were all very sorry that he did not ___ to the university.
A. take it
B. get it
C. make it
D. succeed it
【单选题】
Almost half of that group will experience stress ___ enough to call for professional help.
A. tense
B. moderate
C. bearable
D. intense
【单选题】
If you grow too fast your entire economy could completely shut down and bring growth to a(n) ___.
A. halt
B. cease
C. peak
D. epidemic
【单选题】
I tried my best to drive inside in order to avoid the edges that might make me ___ the steep slope.
A. slip down
B. settle down
C. bring down
D. turn down
【单选题】
When the driver heard that there was a bomb on the bus, he immediately ___ to the side of the highway and radioed the police.
A. put out
B. took off
C. pulled over
D. slipped off
【单选题】
She was very ___ to become a manager in our customers’ office, but finally accepted our offer.
A. eager
B. intelligent
C. ridiculous
D. reluctant
【单选题】
In the race, it looked as if he would be the first, but then another young man who was close behind him put on speed and ___ by a few seconds.
A. beat him for it
B. beat him to it
C. beat him up
D. beat it to him
