【单选题】
导曲线可根据需要设置6mm的超高，并在导曲线范围内按不大于___顺坡。
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【单选题】
导曲线可根据需要设置___的超高，并在导曲线范围内按不大于2‰顺坡。
A. 4mm
B. 5mm
C. 6mm
D. 7mm
【单选题】
护轨平直部分轮缘槽如侧向轨距为___，则侧向轮缘槽标准宽度为48mm，容许误差为（+3，-1）mm。
A. 1439mm
B. 1440mm
C. 1441mm
D. 1442mm
【单选题】
护轨平直部分轮缘槽如侧向轨距为1441mm，则侧向轮缘槽标准宽度为___，容许误差为（+3，-1）mm。
A. 46mm
B. 47mm
C. 48mm
D. 49mm
【单选题】
护轨平直部分轮缘槽如侧向轨距为1441mm，则侧向轮缘槽标准宽度为48mm，容许误差为___mm。
A. +2，-1
B. +2，-3
C. +3，-1
D. +3，-2
【单选题】
正线道岔（直向）与曲线之间的直线段长度，不得短于___。
A. 18m
B. 19m
C. 20m
D. 21m
【单选题】
站线道岔与曲线或道岔与其连接曲线之间的直线段长度，一般不得短于___，困难条件下不得短于6m。
A. 7m
B. 7.3m
C. 7.5m
D. 8m
【单选题】
站线道岔与曲线或道岔与其连接曲线之间的直线段长度，一般不得短于7.5m，困难条件下不得短于___。
【单选题】
各种标志（警冲标除外）应设在钢轨头部外侧不小于2m处。不超过钢轨顶面的标志，可设在距钢轨头部外侧不小于___。
A. 1.15m
B. 1.25m
C. 1.35m
D. 1.45m
【单选题】
各种标志（警冲标除外）应设在钢轨头部外侧不小于___处。不超过钢轨顶面的标志，可设在距钢轨头部外侧不小于1.35m。
A. 1m
B. 1.5m
C. 2m
D. 2.5m
【单选题】
警冲标设在会合轨道线路两线间距为___的起点处中间，有曲线时按限界加宽办法加宽。
A. 2.5m
B. 3m
C. 3.5m
D. 4m
【单选题】
警冲标设在会合轨道线路两线间距不足3.5m 时，应设在___。
A. 靠近左线
B. 靠近右线
C. 两线最大间距的起点处中间
D. 两线最小间距的起点处中间
【单选题】
固定区爬行量超过___时，应分析原因，及时整治。
A. 8mm
B. 9mm
C. 10mm
D. 11mm
【单选题】
当发现线路连续出现___的碎弯时，必须加强巡查（可跟车巡查），观测轨温和线路方向的变化。
A. 1～3mm
B. 2～4mm
C. 3～5mm
D. 4～6mm
【单选题】
当钢轨断缝小于等于50mm时，应立即进行___。
A. 抢修处理
B. 永久处理
C. 紧急处理
D. 临时处理
【单选题】
钢轨折损严重或断缝大于50mm，以及紧急处理后，断缝仍继续扩大，应封锁线路进行___。
A. 永久处理
B. 紧急处理
C. 临时处理
D. 抢修处理
【单选题】
道岔两尖轨尖端相错量不得超过___。
A. 8mm
B. 9mm
C. 10mm
D. 11mm
【单选题】
钢轨接头轨面或内侧错牙不得大于___。
A. 4mm
B. 3mm
C. 2mm
D. 1mm
【单选题】
木枕地段线路捣固时，应在钢轨两侧各___范围内捣实道床，轨下部分加强捣固。
A. 200mm
B. 300mm
C. 400mm
D. 500mm
【单选题】
改道时，混凝土枕地段应调整不同号码扣板、轨距挡板，并可用加垫片的方法调整尺寸，但厚度不得超过___。
A. 5mm
B. 4mm
C. 3mm
D. 2mm
【单选题】
起道前应先___。
A. 除锈
B. 打磨
C. 调整高低
D. 拨正线路方向
【单选题】
木枕宽面在下，顶面与底面同宽时，应使___。
A. 树心一面向左
B. 树心一面向右
C. 树心一面向上
D. 树心一面向下
【单选题】
接头螺栓扭矩不足时，不得低于规定值___以上。
A. 70N·m
B. 80N·m
C. 90N·m
D. 100N·m
【单选题】
缓和曲线与直线连接处不得有___或“鹅头”。
【单选题】
折返线和共线道岔腰鼓螺栓应___在维修时全面更换一次，其他整体道床道岔每隔三年在维修时全面更换一次。
A. 每隔五年
B. 每隔四年
C. 每隔三年
D. 每隔二年
【单选题】
折返线和共线道岔腰鼓螺栓应每隔二年在维修时全面更换一次，其他整体道床道岔___在维修时全面更换一次。
A. 每隔六年
B. 每隔五年
C. 每隔四年
D. 每隔三年
【单选题】
普通线路道岔和无缝线路缓冲区的重伤和折断钢轨应及时___。
A. 设置限速
B. 禁锢扣件
C. 安装急救器
D. 更换
【单选题】
接触网地段需要拨道时，线路中心位置不得超过___。
A. ±15mm
B. ±20mm
C. ±25mm
D. ±30mm
【单选题】
接触网地段需要拨道时，一年单侧累计拨道量不得超过___。
A. 105mm
B. 110mm
C. 115mm
D. 120mm
【单选题】
无论作业中或作业后，发现线路轨向不良，用长10m弦测量两股钢轨的轨向偏差，当平均值达到___时，必须设置慢行信号。
A. 7mm
B. 8mm
C. 9mm
D. 10mm
【单选题】
无论作业中或作业后，发现线路轨向不良，用长10m弦测量两股钢轨的轨向偏差，当平均值达到10mm时，必须设置___。
A. 等待信号
B. 加速信号
C. 停车信号
D. 慢行信号
【单选题】
当两股钢轨的轨向偏差平均值达到12mm时，在轨温不变情况下，过车后线路弯曲变形突然扩大，必须立即设置___。
A. 慢行信号
B. 等待信号
C. 加速信号
D. 停车信号
【单选题】
当两股钢轨的轨向偏差平均值达到___时，在轨温不变情况下，过车后线路弯曲变形突然扩大，必须立即设置停车信号。
A. 9mm
B. 10mm
C. 11mm
D. 12mm
【单选题】
轨道线路爬行量超过___应进行调整。
A. 5mm
B. 10mm
C. 15mm
D. 20mm
【单选题】
出现下列情况___应进行调整。
A. 出现连续四个及以上瞎缝或轨缝小于构造轨缝
B. 出现连续四个及以上瞎缝或轨缝大于构造轨缝
C. 出现连续三个及以上瞎缝或轨缝小于构造轨缝
D. 出现连续三个及以上瞎缝或轨缝大于构造轨缝
【单选题】
正线的最大坡度不宜大于___，困难地段可采用35‰。
A. 15‰
B. 20‰
C. 25‰
D. 30‰
【单选题】
正线的最大坡度不宜大于30‰，困难地段可采用___。
A. 32‰
B. 33‰
C. 34‰
D. 35‰
【单选题】
出入线、联络线和特殊地形地区段的最大坡度不宜大于___。
A. 25‰
B. 30‰
C. 35‰
D. 40‰
【单选题】
疏散平台高度（距轨顶面）应___。
A. 小于等于600mm
B. 小于等于700mm
C. 小于等于800mm
D. 小于等于900mm
【单选题】
折返线、停车线困难情况下，除道岔区外，可设在曲线上，并可不设缓和曲线，超高应为___。
A. 0mm～12mm
B. 0mm～13mm
C. 0mm～14mm
D. 0mm～15mm
【单选题】
折返线、停车线在车挡前宜保持不少于___的直线段。
A. 17m
B. 18m
C. 19m
D. 20m
推荐试题
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
【判断题】
5)Bioavailability of a drug indicates whether a therapeutically effective concentration is achieved at the site(s)of action of that drug.
【判断题】
(6)Prodrugs are not therapeutically effective unless they are changed into therapeutically active forms before or after reaching the systemic circulation
