相关试题
【多选题】
ENRICH研究中，接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后，达到MR4的患者比例为
A. 0.54
B. 0.64
C. 0.73
D. 0.88
【多选题】
ENESTxtnd研究中，一线达希纳治疗反应欠佳或治疗失败后增加剂量治疗后患者24个月内达到MMR的比例超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENESTxtnd研究中，一线达希纳300mg BID治疗反应欠佳或治疗失败后患者允许增加剂量至
A. 350 mg BID
B. 400 mg BID
C. 450 mg BID
D. 500 mg BID
【多选题】
ENESTxtnd研究发现一线达希纳治疗反应欠佳或治疗失败后增加达希纳剂量可获得较高的MMR率。
【多选题】
ENESTswift 研究中大约三分之一的患者在因对伊马替尼或达沙替尼耐受不良而改用达希纳3个月后达到
A. 无MMR
B. MMR
C. MR4
D. MR4.5
【多选题】
ENESTop研究中MMR丢失或MR4确认丢失后重新启动后，每月监测一次，直到以前的MMR或MR4重新建立，此后监测时间为
A. 每4周一次
B. 每6周一次
C. 每12周一次
D. 每半年一次
【多选题】
ENESTop研究中，在符合严格的TFR尝试资格标准的患者中，停药144周后仍可保持TFR(无MMR丢失或MR4确认丢失)的患者比例为
A. 0.189
B. 0.237
C. 0.376
D. 0.484
【多选题】
ENESTnd研究中接受达希纳治疗的患者在6年内未进展至AP/BC的比例为
A. 0.87
B. 0.61
C. 0.59
D. 0.99
【多选题】
ENESTnd研究中接受达希纳300 mg BID 治疗3个月时达到EMR的中度SOKAL风险患者的比例为
A. 0.89
B. 0.9
C. 0.91
D. 0.92
【多选题】
ENESTnd研究中，在发生突变的患者中，伊马替尼治疗出现治疗失败的患者数量为达希纳治疗的
A. 2倍
B. 2.5倍
C. 3倍
D. 4倍
【多选题】
"ENESTnd研究中，伊马替尼组MR4.5累积率不及达希纳治疗组，并且持续证实了MR4.5率比达希纳组更低的随访时间为
【多选题】
ENESTnd研究中，伊马替尼治疗CML患者发生突变比达希纳治疗的患者多
A. 1.5倍
B. 2倍
C. 2.5倍
D. 3倍
【多选题】
ENESTnd研究中，随访5年，达希纳一线治疗组疾病进展至AP/BC的患者数与伊马替尼相比，显著更少，分别为（ ）例和（ ）例。
A. 5，5
B. 6，7
C. 2，12
D. 8，9
【多选题】
ENESTnd研究中，达希纳组疾病进展（ ）伊马替尼组。
A. 低于
B. 高于
C. 等于
D. 以上均不正确
【多选题】
ENESTnd研究中，达希纳组患者维持在慢性期的比例是（ ）。
A. 0.9
B. 0.85
C. 0.99
D. 0.8
【多选题】
ENESTnd研究中，达希纳与格列卫一线治疗6年累积达到MR4.5的患者比例的差值
A. 逐渐缩小
B. 逐渐增大
C. 基本不变
D. 先增大后缩小
【多选题】
ENESTnd研究中，达希纳一线治疗6年累积达到MR4.5的患者比例为
A. 0.49
B. 0.52
C. 0.56
D. 0.58
【多选题】
ENESTnd研究中，达希纳体现了良好的耐受性，48个月时达希纳300mg BID组患者的实际用药剂量达预期剂量的（ ）。
A. 0.8
B. 0.85
C. 0.9
D. 0.99
【多选题】
ENESTnd研究中，达希纳累积MR4.5率与伊马替尼相比的结果是（ ）。
A. 达希纳持续优于伊马替尼
B. 伊马替尼优于达希纳
C. 结果无差别
D. 以上均不正确
【多选题】
ENESTnd研究中，达希纳300mgBID组中获得MR4.5的患者在60个月时发生疾病进展的人数为（ )。
【多选题】
ENESTnd研究随访五年时，以下哪个研究终点，达希纳300mg BID 和伊马替尼组之间反应差异率为23%？
A. MMR
B. MR4.0
C. MR4.5
D. MR5.0
【多选题】
ENESTnd研究landmark分析中，达希纳300mg BID治疗第五年哪组患者的结局百分率为97%？
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd研究landmark分析中，达希纳300mg BID治疗第六年哪组患者的结局百分率为94.5%？
A. 3个月BCR-ABL > 10%的患者总生存期
B. 3个月BCR-ABL ≤ 10%的患者总生存期
C. 3个月BCR-ABL > 10%的患者无进展生存
D. 3个月BCR-ABL ≤ 10%的患者无进展生存
【多选题】
ENESTnd试验核心研究中，有多少患者在第五年发生新的疾病进展？
【多选题】
ENESTnd的主要研究终点是（ ）。
A. 12个月时获得的MMR
B. 6个月时获得的MMR
C. 12个月时获得的CCyR
D. 12个月时获得的CCyR
【多选题】
ENESTnd 研究中，随访到第5年时，达希纳300mgBID和伊马替尼治疗组的患者中，累积达到MMR的患者的百分比是多少？
A. 55%、27%
B. 62%、40%
C. 76%、56%
D. 77%、60%
【多选题】
ENESTnd 研究中，达希纳300mg BID 和伊马替尼组患者在以下哪个milstone的百分比分别为91%和 67%？
A. 6个月Bcr-Abl ≤ 1%
B. 6个月Bcr-Abl > 1%
C. 3个月Bcr-Abl ≤ 10%
D. 3个月Bcr-Abl > 10 %
【多选题】
ENESTnd 研究中，达希纳300mg BID 和伊马替尼组患者在三个月没有达到BCR-ABL ≤ 10%的百分比是多少？
A. 7% 和 29%
B. 7% 和 30%
C. 9% 和 30%
D. 9% 和 33%
【多选题】
ENESTnd 研究中，达希纳300mg BID 和伊马替尼组患者在12个月时累计的MMR率是多少？
A. 40% 和 23%
B. 54% 和 31%
C. 60% 和 31%
D. 55% 和 27%
【多选题】
ENESTnd 研究随访到5年时，达希纳300mgBID和伊马替尼组的患者中，达到MR4.5的患者的百分比是多少？
A. 32%、15%
B. 40%、 23%
C. 42%、 24%
D. 54%、 31%
【多选题】
ENESTFreedom研究中，重启治疗的标准是
A. 丧失MR4.5
B. 丧失MMR
C. 丧失CCyR
D. 疾病进展
【多选题】
ENESTFreedom研究中，无治疗生存期指进入TFR后至首次发生（）的时间
A. 未实现MMR
B. 未实现MR4.5
C. 任何情况下重启尼洛替尼治疗
D. 疾病进展为加速期/白血病急变期
【多选题】
ENESTFreedom研究中，停药后48周维持TFR的患者比例为
A. 0.442
B. 0.516
C. 0.589
D. 0.56
【多选题】
ENESTFreedom研究中，巩固期PCR检测频率为
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
ENESTFreedom对持续深层分子学反应的定义为：最近4次PCR评估中，
A. 最近一次的评估结果不劣于MR4
B. 最近一次的评估结果不劣于MR4.5
C. MR4和MR4.5之间≤2项评估
D. MR4和MR4.5之间≤1项评估
【多选题】
ENESTfreedom 研究中，由于不稳定DMR没有尝试TFR资格的患者经达希纳治疗1年后可获得尝试TFR的资格。
【多选题】
ENESTcmr研究中伊马替尼进行一线治疗的CML患者，较继续使用伊马替尼，更多的患者通过二线达希纳获得DMR。
【多选题】
ENESTcmr研究中，与使用伊马替尼相比， 使用达希纳实现首次MR4.5的中位时间缩短了
A. 3个月
B. 6个月
C. 1年
D. 2年
【多选题】
ENESTchina中，中国CML 发病的中位年龄是（ ）。
【多选题】
ENESTchina的主要研究终点是（ ）。
A. 12个月的MMR，定义为BCR-ABL≤0.1%
B. 6个月的MMR，定义为BCR-ABL≤0.1%
C. 24个月的MMR，定义为BCR-ABL≤0.1%
D. 36个月的MMR，定义为BCR-ABL≤0.1%
推荐试题
【单选题】
Tom is a book lover. ______ likes reading very much.
A. He B. She C. You D. It
【单选题】
—May I listen to the music here, Mr. White?
—Sorry, you’d better it like that．
A. not to do B. not do to
C. dont do D. not do
【单选题】
3.—Did you have a good time at Lauras birthday party?
— Yes, indeed. Its several years ________ I enjoyed myself so much.
A. when B. before C. since D. that
【单选题】
4. —___________ is the Summer Palace from here?
About three kilometers away. You can take the No. 35 bus.
A. How long B. How far C. How often D. How much
【单选题】
5. I was looking for a birthday gift for my mother, but I couldnt find ______ suitable.
A. anything B. something C. nothing D. everything
【单选题】
6. A friend of my ____ and I are going to visit_______ next week．
A. father; Browns B. father's; Browns
C. father; the Browns D. father's; the Browns
【单选题】
7. She ______ very hard since she came to our school.
A. studies B. has studied C. is studying D. studied
【单选题】
8. — Who will send you to the new school, your mom or your dad?
— _______. Ill go there by myself.
A. Both B. Either C. Neither D. None
【单选题】
9.—Well do what we can ____English well this term．
—It’s high time for you to work hard．
A. study B．to study C. be studied D. be studying
【单选题】
10. —I’m going to Flower Bookstore. Could you tell me ______?
— Sorry, I don’t know. I’m new here.
A. where it is B. where was it C. where is it D. where it was
【单选题】
11. How do you like the dishes, Eric?
— Fantastic! Nothing tastes ________.
A. nice B. better C. terrible D. worse
【单选题】
12. ______ Lin Feng has to work late, she always wears a smile on her face.
A. Because B. If C. Until D. Though
【单选题】
13.You can save money _______ you buy cheaper things.
A. before B. unless C. if D. until
【单选题】
14. We will have a _________ holiday after the exam．
A. two-month B. two month’s C. two month D. two-months
【单选题】
15. —We will build an underground in Xuzhou before 2015．
— Wow, _______! Will it pass our place?
A. what an excited news B. how excited the news is
C. what exciting news D. how exciting
【单选题】
16. — Emily, here’s a dictionary．I hope it will help you in some way．
— Thank you．It’s ________ what I need．
A. almost B. still C. only D. just
【单选题】
17. —Oh．I’m hungry．Mum, can I have the hamburger on the plate?
—No．It tastes ．
A. terribly B. terrible C. good D. well
【单选题】
18. —We can invite our teachers to the farewell party next Saturday.
—Yes, ______? I’ll call them at once.
A. what for B. what C. why not D. why
【单选题】
19.You can ________ ask the old man to move away to any other place because he has lived ________ here for at least sixty years．
A. hardly; alone B. hard; alone
C. hardly; lonely D. hardly; lonely
【单选题】
20.—I’m going back to see my grandparents this weekend．
—________．
A. It’s very nice of you B. You’d better hurry
C. Say goodbye to them D. Give my best wishes to them
【单选题】
21.—Why not take ____ umbrella with the sign “Made in China”? It is useful.
—What _______ good advice it is!
A. an; a B. a; a C. an; \ D. \; a
【单选题】
22. —Do you know the boy________ is sitting next to Peter?
— Yes. He is Peter’s friend. They are celebrating his ________ birthday.
A. who; ninth B. that; ninth C. /; ninth D. which; ninth
【单选题】
23. It was dark, ______ I couldnt see what was happening.
A. or B. though C. but D. so
【单选题】
24.—You can use MSN to talk with Vivien on the Internet.
—I know. But can you tell me ________?
A. what I can use it B. when I can use it
C. why can I use it D. how can I use it
【单选题】
25. _______ are you going to the School Uniform Exhibition, Amy ?
To learn about different styles of school uniform.
A. What B. Where C. Which D. Why
【单选题】
( ) 26. Where does the writer of "The little Prince" come from?
A．England． B．France． C．America． D．China．
【单选题】
( ) 27. What does the prince do after the fox tells him a secret?
A．He cares more about a flower and a sheep．
B．He meets many more strange adults on other planets．
C．He realizes his love for the rose and he goes back to his planet．
D．He discovers interesting things such as a snake, other roses and a fox
【单选题】
( ) 28. What does "The little Prince" mainly talk about? It' s about _________．
A．the adult world B．the planet B -612
C．a rose and a fox D．the adventure of a young prince
【单选题】
( ) 29. What is the writer's main purpose（目的）in writing this passage？
A．To tell the readers his life story．
B．To tell people what kind of person his father was．
C．To tell the readers what present he got from his father．
D． To let people know how poor he was．
【单选题】
( ) 30. Why did the father not ask his son not to do this and do that？
A．Because he felt quite confident of his son．
B．Because he was born from a poor family．
C．Because he was a man of few words．
D．Because he didn't want to be much too strict with his son．
【单选题】
( ) 31. What would someone learn from this passage？
A．How to live by oneself． B．How to stand on one's own feet．
C．What a good father should do． D．What the self-important is like．
【单选题】
( ) 32. What may be the proper Chinese for the underlined part in the passage？
A．闲暇时光 B．学费 C．精神空虚 D．经济不足
【单选题】
( ) 33. Why did Natalie Smith pay for the six cars behind her?
A. She had seven tickets.
B. She hoped to please others.
C. She knew the car drivers well.
D. She wanted to show kindness.
【单选题】
( ) 34. Judy Foreman copied down the phrase because she ___ .
A. thought it was beautifully written
B. wanted to know what it really meant
C. decided to write it on a warehouse wall
D. wanted her husband to put it up in the classroom
【单选题】
( ) 35. Who came up with the phrase according to the passage?
A. Judy Foreman. B. Natalie Smith. C. Anne Herbert D. Alice Johnson.
【单选题】
( ) 36. What can we infer from the last paragraph?
A. People should practice random kindness to those in need.
B. People who receive kindness are likely to offer it to others.
C. People should practice random kindness to strangers they meet.
D. People who receive kindness are likely to pay it back to the giver.
【单选题】
( ) 37.The greatest river for navigation is ___________.
A. the Nile B. the Amazon C. the Mekong D. the Mississippi
【单选题】
( ) 38. From a dam, people can use the water for ___________.
A. keeping the rivers clean B. only making electricity
C. irrigation and making electricity D. washing clothes
【单选题】
( ) 39. The water in the river is polluted because of _____________.
A. people's drinking water too much B. people's swimming in the river too much
C. chemicals and other materials D. people's building a dam across a river
【单选题】
( ) 40. The best title of the passage is ___________.
A. Rivers in Cities B. The importance of Rivers
C. Transportation D. Natural Resources
