【多选题】
由于药物相互作用，服用达希纳时，应该避与（ ）同时使用。
A. 酮康唑
B. 伊曲康唑
C. 伏立康唑
D. 克拉霉素
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相关试题
【多选题】
以下英文缩写与中文正确对应的是（ ）
A. PCyR：部分细胞遗传学反应
B. CCyR：完全细胞遗传学反应
C. MMR：主要分子学反应
D. 所有选项均不正确
【多选题】
以下哪个说法是正确的是（ ）。
A. 所有TKI由于抑制野生型Bcr-Abl，都会对心血管系统产生影响
B. 临床试验证实：达希纳治疗患者的心血管事件发生率与同年龄组普通人群相似
C. 所有进行TKI治疗的CML患者，都应该进行心血管风险因素的评估
D. 所有选项均不正确
【多选题】
以下（ ）情况需要慎用达希纳。
A. 长QT综合征
B. 肝损害，电解质紊乱
C. 胰腺炎，严重的糖尿病
D. 所有选项均不正确
【多选题】
属于CYP3A4诱导剂的是（ ）。
A. 利福平
B. 卡马西平
C. 苯巴比妥
D. 贯叶连翘
【多选题】
如果临床需要，达希纳可与造血生长因子联合使用。
【多选题】
如果临床需要，达希纳可与造血生长因子或其他联用，例如（ ）。
A. EPO
B. G-CSF
C. 羟基脲
D. 阿那格雷
【多选题】
如果出现血液学毒性( )，应暂停达希纳的使用。
A. 加速期：ANC<0.5×109/升或血小板<10×109/升
B. 慢性期：ANC<1.0×109/升或血小板<50×109/升)
C. 加速期：ANC<1×109/升或血小板<10×109/升
D. 慢性期：ANC<10×109/升或血小板<50×109/升
【多选题】
评价二代TKI做为新诊断CML-CP患者一线治疗疗效和安全性研究的临床试验包括（ ）。
A. ENESTnd
B. ENESTchina
C. DASISION
D. ENESTcmr
【多选题】
哪些属于血液学不良反应（ ）。
A. 血小板减少症
B. 中性粒细胞减少症
C. 腹泻
D. 贫血
【多选题】
哪些属于非血液学不良反应（ ）。
A. 中性粒细胞减少症
B. 胃肠道异常
C. 皮疹
D. 肌痛
【多选题】
关于ENESTnd和ENESTchina 研究, 以下说法正确有（ ）。
A. ENESTnd是3臂试验，ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTnd中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
骨髓抑制一般是可逆的，可以通过暂时停达希纳或降低剂量来控制。
【多选题】
根据ELN指南，达到满意疗效的Bcr-Abl转录本的水平是（ ）。
A. TKI 治疗3个月，Bcr-Abl ： ≤ 10%
B. TKI 治疗6个月，Bcr-Abl ： ≤ 1%
C. TKI 治疗12个月，Bcr-Abl ：≤0.1%
D. 所有选项均不正确
【多选题】
服用达希纳时，应注意的事项有（ ）。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
服用达希纳时，如果出现有显著临床意义的中度或严重的非血液学毒性，应该暂停服药。
【多选题】
服用达希纳时，任何时候都应该避免进食（ ）。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
达希纳能够抑制（ ）激酶的自磷酸化。
A. Bcr-Abl（20-60nM）
B. PDGFR（69nM）
C. Src
D. c-Kit（210nM）
【多选题】
达希纳胶囊服用时，可以咀嚼或吮吸，可以打开胶囊。
【多选题】
达希纳含有乳糖，所以对于（ ）的患者，不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳服用时，如果错过给药，患者不得另外补充剂量，而是按照处方服用下一次剂量。
【多选题】
伴有（ ）的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
TKI治疗均的CV风险管理中，属于可更改的因素有（ ）。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
【多选题】
TKI治疗均的CV风险管理中，属于不可更改的因素有（ ）。
【多选题】
ENESTnd研究中的分组有（ ）。
A. 达希纳300mg BID
B. 达希纳400mg BID
C. 伊马替尼400mg QD
D. 伊马替尼400mg BID
【多选题】
ENESTnd研究中，在5年随访中，所有时间点达希纳组MMR的比例始终高于伊马替尼组。
【多选题】
ENESTnd研究中，与伊马替尼相比，达希纳一线治疗组疾病进展至AP/BC显著更少。
【多选题】
ENESTnd研究中，排除（ ）类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
ENESTnd研究中，从第一年至第五年的随访中，达希纳和伊马替尼组累积的MR4.5相差的比例保持完全不变。
【多选题】
ENESTnd标志性分析中，3个月时获得BCR-ABLIS≤10%与60个月时更佳的OS无关
【多选题】
在TIDEL-II研究中，服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在ENESTnd研究中，在伊马替尼400mg每天治疗失败后将剂量增加至600或800 mg每天不会导致超过一半的患者反应改善。
【多选题】
在ENESTnd研究所有风险组中，伊马替尼治疗的EMR失败率比达希纳高3-4倍。
【多选题】
在ENESTnd或DASISION研究中，5年随访时，伊马替尼二线治疗组获得MR4.5的中位时间均未达到。
【多选题】
"与竞品达沙替尼相比，达希纳精准强效抑制BCR-ABL
【多选题】
与竞品达沙替尼相比，达希纳非血液学不良反应交叉不耐受发生率高？
【多选题】
以下关于DASISION研究的描述，正确的是（ ）。
A. DASISION试验的研究终点是CCyR，而不是MMR
B. DASISION试验中，达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中，达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
IRIS研究中，伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
IRIS研究随访10年, 32% 伊马替尼治疗患者由于不满意治疗反应中断治疗，＞10%由于不良事件。
推荐试题
【单选题】
Which method is supported for backing up the virtual machine that contains vCenter Server?___
A. differential
B. incremental
C. full image
D. individual disks
【单选题】
A vSphere Administrator must ensure that a user is able to view and manage the system configuration in vSphere Web Client. In the vCenter Single Sign-On domain, which group should the user be a part of?___
A. SystemConfiguration.BashShellAdministrators
B. ComponentManager. Administrators
C. Administrators
D. SystemConfiguration.Administrators
【单选题】
What is the minimum number of hosts that must contribute capacity to a non-ROBO single site VMware vSAN cluster?___
【单选题】
Which guest operating system supports PVRDMA?___
A. Windows (32-Bit)
B. Linux (32-Bit)
C. Windows (64-Bit)
D. Linux (64-Bit)
【单选题】
What is the correct way to replace the certificate on an existing vCenter Server that is part of a vCenter HA configuration?___
A. Put the vCenter HA in Maintenance mode, replace the certificate, exit Maintenance mode.
B. Shut down Passive and Witness nodes and replace the certificate on the Active node.
C. Remove the Passive and Witness nodes, replace the certificate, reconfigure the cluster.
D. Replace the certificate while all nodes are participating in the cluster.
【单选题】
The vSphere Data Protection performance analysis results in the “Conditionally Passed” status. What can cause this condition?___
A. The results did not meet the minimum performance expectations.
B. The read, write, and seek tests were successful.
C. The read and write tests were successful but the seek test failed.
D. The read and write tests were successful but the seek test skipped.
【单选题】
A vSphere Administrator wants to reserve 0.5 Gbps for virtual machines on each uplink on a disturbed switch that has 10 uplinks. What is the quota that should be reserved for the network resource pool?___
A. 10 Gbps
B. 5 Gbps
C. 100 Gbps
D. 0.5 Gbps
【单选题】
A vSphere administrator manages a cluster which includes critical and non-critical virtual machines. The cluster requires different permissions for contractors and non-contractors. How can the administrator exclude the contractor group from some of the critical VMs?___
A. Apply permission for both contractors and non-contractors on the cluster level.
B. Apply permission for both contractors and non-contractors on the cluster level. Remove permission on the critical VMs for contractors.
C. Remove permission for contractors on the cluster level. Apply permission on the critical VMs for noncontractors.
D. Apply permission for both contractors and non-contractors on the VMs. Remove permission on the critical VMs for contractors.
【单选题】
In an ESXi 6.5 cluster only "NFS datastore has running or registered virtual machines" returns. A vSphere HA cluster with four hosts has admission control configured to tolerate one host failure. Which statement is true if a fifth host is added?___
A. CPU and Memory capacity will be set to 50%.
B. CPU and Memory capacity will be set to 30%.
C. CPU and Memory capacity will be set to 25%.
D. CPU and Memory capacity will be set to 20%.
【单选题】
Which command can be run to troubleshoot connectivity problems with vmkernal network interfaces?___
A. esxcli network
B. vmkping
C. net-status
D. vicfg-vmknic
【单选题】
What counter should an administrator check to determine if a virtual machine is ballooning?___
A. swapinRate
B. vmmemctltarget
C. swapped
D. vmmemctl
【单选题】
By default, how often is the vCenter vpx user password automatically changed?___
A. 15 days
B. 60 days
C. 30 days
D. 45 days
【单选题】
Which metric in the Exhibit would identify high latency for a virtual machine operating system?___
A. QAVG/cmd
B. KAVG/cmd
C. DAVG/cmd
D. GAVG/cmd
【单选题】
What VM Monitoring setting would ensure that the failure interval for a virtual machine is defined as 120 seconds?___
A. High
B. Normal
C. Low
D. Medium
【单选题】
The business managers have asked the IT administrator to ensure configuration compliance in the vSphere infrastructure. The IT administrator wants to use Host Profiles to accomplish this, but is unable to do so. Why is the administrator unable to use Host Profiles?___
A. The infrastructure uses a vSphere Standard license.
B. The infrastructure has servers with various CPU families.
C. The user has only the “Administrator” role.
D. Host Profiles apply only to storage settings.
【单选题】
What is the result of a “Consolidate” action on a virtual machine?___
A. All snapshots on the virtual machines will be deleted.
B. The virtual machine will be reverted to its last snapshot.
C. Redundant delta disks will be combined and deleted.
D. A new snapshot with memory state will be created.
【单选题】
A Telco customer is implementing NFV using vSphere as the virtualization platform. Which feature can help achieve a high packet rate with lower CPU consumption?___
A. Network I/O Control
B. SplitRX
C. ERSPAN
D. LACP
【单选题】
What is the VMware-recommended best practice for Fibre Channel zoning?___
A. soft zoning
B. single-initiator-multiple-target zoning
C. single-initiator zoning
D. single-initiator-single-target zoning
【单选题】
How can a vSphere administrator ensure that a set of virtual machines run on different hosts in a DRS cluster?___
A. Use a VM-Host affinity rule.
B. Add the VMs to a vApp.
C. Use a VM-VM affinity rule.
D. Place the VMs in different folders.
【单选题】
vCenter Server Appliance Instance can be backed up using which Client Interface?___
A. vSphere Client Interface
B. vSphere Web Client Interface
C. VMware Host Client Interface
D. Virtual Appliance Management Interface
【单选题】
What tool can capture network traffic at the uplinks, or vSwitch, or virtual port levels?___
A. tcpdump-uw
B. wireshark
C. pktcap-uw
D. pcap
【单选题】
Which storage feature always requires the use of third-party software on ESXi?___
A. Hardware Acceleration for NAS devices
B. VVOL
C. Hardware Acceleration for Block
D. evices
【单选题】
An ESXi host's VMCA-Signed certificate has expired. How can the certificate be renewed?___
A. In the vSphere Web Client, browse to the host in question. Click the Manage tab and select settings. Select System and click Certificate, then click the Renew button.
B. In the vSphere Web Client, browse to the host in question. Click the Manage tab and select settings. Select System and click Certificate, then click the Refresh CA Certificates button.
C. Run the command /sbin/generate-certificates on the affected host.
D. Disconnect the host from vCenter Server and reconnect it.
【单选题】
Which is the correct order for upgrading vSphere components?___
A. vCenter Server, ESXi hosts, VMware Tools, Virtual Machine hardware
B. VMware Tools, Virtual Machine hardware, ESXi hosts, vCenter Server
C. vCenter Server, Virtual Machine hardware, VMware tools, ESXi hosts
D. ESXi hosts, vCenter Server, Virtual Machine hardware, VMware Tools
【单选题】
Which iSCSI initiator type can be used with any network interface card?___
A. Software iSCSI initiator
B. Software FCoE adapter
C. Hardware Independent iSCSI initiator
D. Hardware Dependent iSCSI initiator
【单选题】
An administrator is attempting to power on a virtual machine with 32GB of memory. The operation fails with the following error: <Could not power on VM: No space left on device> <Checking the space on the virtual machine's datastore, there is 30GB free.> Which action would allow the VM to power on?___
A. Set a 2GB memory reservation on the VM.
B. Mount the virtual disk from the affected VM on to another virtual machine and free up space from within the OS.
C. Enable vSphere HD admission control on the cluster in which the VM resides.
D. Set a 2GB memory limit on the VM.
【单选题】
An administrator attempts to manually reclaim space on thin-provisioned VMFS6 volumes but finds that no additional space is being recovered. Which could be causing this?___
A. vSphere 6.5 does not support manual UNMAP.
B. The manual UNMAP operation has been moved to the vSphere web client.
C. The VASA version is use is incompatible.
D. UNMAP is automated for VMFS6.
【单选题】
An administrator has upgraded to vSphere 6.5 and also wants to use Kerberos authentication for NFS. Which can be done to the existing NFSv3 volumes to enable this feature?___
A. Perform a storage rescan on VMFS volumes.
B. Unmount the NFSv3 datastore, and then mount as NFSv4.1 datastore.
C. Nothing. All NFSv3 mounted datastores are upgraded automatically during vSphere upgrades.
D. Perform a scan of new storage devices.
【单选题】
An administrator wants to restore the vCenter Server Appliance 6.5 from backup. Where can this be accomplished?___
A. from the ESXi Host Client
B. from the VMware vSphere Appliance Management Interface
C. from within the VMware vSphere Web Client
D. from the vCenter Server Appliance Installer
【单选题】
The administrator wants to power on VM-K2, which has a 2GHz CPU reservation. VM-M1, VM-M2, and VM-K1 are all powered on. VM-K2 is not powered on. The exhibit shows the parent and child resource reservations. If Resource Pool RP-KID is configured with an expandable reservation, which statement is true?___
A. VM-K2 will be unable to power on because there are insufficient resources.
B. VM-K2 will be able to power on since resource pool RP-KID has 2GHz available.
C. VM-K2 will be unable to power on because only 2GHz are reserved for RP-KID.
D. VM-K2 will receive resource priority and will be able to power on this scenario.
【单选题】
Which is the block size on the VMFS6 datastore?___
A. All small and large file blocks are 8MB.
B. All small and large file blocks are 1MB.
C. Small file blocks are 512KB. large file blocks are 64MB.
D. Small file blocks are 1MB, large file blocks are 512MB.
【单选题】
When installing vCenter Converter Standalone, why must an administrator perform a client-server installation instead of a local installation?___
A. to manage conversion tasks remotely
B. to convert virtual machines as well as physical machines
C. to allow installation of the Converter agent on remote source machines
D. to hot clone physical or virtual machines
【单选题】
Which is required by vCenter Converter Standalone to convert a physical Red Hat Enterprise Linux 7 machine to a virtual machine?___
A. The Linux machine must be powered off.
B. The Linux machine must have the SSH daemon started.
C. The Linux machine must use a static IP address.
D. The Linux machine must have a fully-qualified domain name.
【单选题】
An administrator is troubleshooting network communications between a vCenter Server and an ESXi 6.5 host. Which log shows the related events between these components?___
A. /var/log/fdm.log
B. /var/log/vpxa.log
C. /var/log/hostd.log
D. /var/log/auth.log
【单选题】
An administrator has recently upgraded from vSphere 6.0 to 6.5, and can no longer see the software iSCSI named vmhba33. Which could be the reason for this?___
A. The upgrade has changed the vmhba name.
B. vSphere 6.5 automates iSCSI configurations.
C. vSphere 6.5 no longer supports software iSCSI.
D. The upgrade has deleted the vmhba.
【单选题】
An administrator is trying to vMotion a VM from his datacenter to a recovery site. Which is the maximum allowed RTT (Round-Trip Time) latency between source and destination host?___
A. 100 milliseconds
B. 150 milliseconds
C. 15 milliseconds
D. 10 milliseconds
【单选题】
Which is required for configuring iSCSI Software Adapter network port binding?___
A. VMkernel of the iSCSI traffic must be load balanced using Route based on IP Hash algorithm.
B. VMkernel of the iSCSI traffic must be load balanced using Route based on Source Virtual Port ID algorithm.
C. VMkernel of the iSCSI traffic must be load balanced using Route based on Source MAC Hash algorithm.
D. VMkernel of the iSCSI traffic must be bound to only one active network adapter.
【单选题】
In vSphere Data Protection 6.1, which is the function of a Backup Verification job?___
A. None. Backup Verification job is not a feature of vSphere Data Protection
B. It is a manual task -Power it on -Verify the guest OS -Check started applications
C. It is an automatic process -Restore a virtual machine -Power it on -Verify that the guest OS is booted by communicating with the Backup Verification agent
D. It is an automatic process -Restore a virtual machine -Power it on -Verify that the guest OC is booted by detecting the VMware ToolsTM "heartbeats"
【单选题】
An administrator has enabled vSphere Distributed Switch Health Check. The hosts connected to that Distributed Switch all display an alert:< vSphere Distributed Switch MTU supported status > .The administrator has all of the VMkernel ports MTU sizes set to 1600. Which action will remedy this problem?___
A. Configure the Distributed Switch to MTU 9100.
B. Disconnect and reconnect the physical network cable.
C. Configure the physical switch to MTU 1600.
D. Disable the Distributed Switch MTU.
【单选题】
Which Host Profile Subprofile configuration is used to configure firewall settings for ESXi hosts?___
A. Advanced Configuration Settings
B. General System Settings
C. Security
D. Networking
